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1.发明公开
公开(公告)号：EP4029519A1
公开(公告)日：2022-07-20
申请号：EP22154751.6
申请日：2008-04-11
发明人： Oppenheimer, Daniel , Dorenbaum, Alejandro , OKHAMAFE, Augustus , Foehr, Erik , Castillo, Sianna , Kostel, Paul
IPC分类号： A61K45/06 , A61K9/20 , A61K9/48 , A61K31/519 , A61P3/00 , A61P3/02 , A61P25/16 , A61K9/00 , A61K9/16 , A61P7/06 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/24 , A61P25/28 , A61P43/00 , C07D487/04 , C07B63/00 , G01N30/72
摘要： The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food for treating BH4-responsive disorders. Also disclosed are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
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公开(公告)号：EP3977999A1
公开(公告)日：2022-04-06
申请号：EP21209606.9
申请日：2004-11-17
IPC分类号： A61K31/519 , A61P3/00
摘要： The present invention is directed to novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes compositions comprising tetrahydrobiopterin (BH4) and the use thereof in methods of treating various types of phenylketonurias. Combination therapies of BH4 and other therapeutic regimens are contemplated.
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3.发明公开
公开(公告)号：EP3461503A1
公开(公告)日：2019-04-03
申请号：EP18205446.0
申请日：2008-04-11
发明人： Oppenheimer, Daniel I. , Dorenbaum, Alejandro , Okhamafe, Augustus , Foehr, Erik , Castillo, Sianna , Kostel, Paul John
摘要： The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
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4.发明公开Methods of administering tetrahydrobiopterin, associated compositions, and methods of measuring 审中-公开施用四氢生物蝶呤的方法，相关的组合物和测量方法
公开(公告)号：EP2545939A3
公开(公告)日：2013-06-12
申请号：EP12005352.5
申请日：2008-04-11
发明人： Oppenheimer, Daniel I. , Dorenbaum, Alejandro , Okhamafe, Augustus , Foehr, Erik , Castillo, Sianna , Kostel, Paul John
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0053 , A61K9/0065 , A61K9/0095 , A61K9/08 , A61K9/1652 , A61K9/2027 , A61K9/2054 , A61K9/2086 , A61K9/4808 , A61K9/4858 , A61K9/4891 , A61K45/06 , C07B63/00 , C07D487/04 , G01N27/62 , G01N30/7233 , G01N33/6848 , H01J49/004 , Y10T436/147777 , A61K2300/00
摘要： The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
摘要翻译： 本发明涉及四氢生物喋呤管理，包括口服剂型，在静脉内式蒸发散的治疗方法，并用食品。 因此，在生物蝶呤是用于测量在一游离缺失样品盘生物蝶呤和生物喋呤的代谢物的量测定。
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5.发明公开Methods of administering tetrahydrobiopterin, associated compositions, and methods of measuring 审中-公开施用四氢生物蝶呤的方法，相关组合物和测量方法
公开(公告)号：EP2545939A2
公开(公告)日：2013-01-16
申请号：EP12005352.5
申请日：2008-04-11
发明人： Oppenheimer, Daniel I. , Dorenbaum, Alejandro , Okhamafe, Augustus , Foehr, Erik , Castillo, Sianna , Kostel, Paul John
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0053 , A61K9/0065 , A61K9/0095 , A61K9/08 , A61K9/1652 , A61K9/2027 , A61K9/2054 , A61K9/2086 , A61K9/4808 , A61K9/4858 , A61K9/4891 , A61K45/06 , C07B63/00 , C07D487/04 , G01N27/62 , G01N30/7233 , G01N33/6848 , H01J49/004 , Y10T436/147777 , A61K2300/00
摘要： The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
摘要翻译： 本发明涉及给予四氢生物蝶呤的治疗方法，包括口服剂型，静脉内制剂和食物。 本文还公开了用于测量样品中生物蝶呤和生物蝶呤代谢物的量的生物蝶呤测定法。
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