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公开(公告)号：EP3256853A1
公开(公告)日：2017-12-20
申请号：EP16704567.3
申请日：2016-02-09
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON-Translationale Onkologie an der Universitätsm Universitätsmedizin der Johannes Gutenberg- Universtität Mainz gGmbH
发明人： SAHIN, Ugur , LÖWER, Martin , TADMOR, Arbel, D. , BOEGEL, Sebastian , SCHRÖRS, Barbara , VORMEHR, Mathias , KREITER, Sebastian
CPC分类号： G01N33/505 , A61K39/0011 , G01N33/6845 , G01N2333/70539 , G01N2500/04
摘要： The present invention relates to methods for predicting T cell epitopes useful for vaccination. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic and, in particular, useful for vaccination, or for predicting which of such modifications are most immunogenic and, in particular, most useful for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.
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公开(公告)号：EP3484445A1
公开(公告)日：2019-05-22
申请号：EP17743293.7
申请日：2017-07-14
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON-Translationale Onkologie an der Universitätsm Universitätsmedizin der Johannes Gutenberg- Universtität Mainz gGmbH
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公开(公告)号：EP3390433A1
公开(公告)日：2018-10-24
申请号：EP16825355.7
申请日：2016-12-16
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C07K14/54 , C07K14/705 , C12N15/62
CPC分类号： C12N15/62 , C07K14/54 , C07K14/70578 , C07K2319/00
摘要： The present invention relates to cytokine fusion proteins and to nucleic acid molecules encoding such cytokine fusion proteins. The present invention further relates to cells, non-human organisms, pharmaceutical compositions and kits comprising the cytokine fusion proteins or the nucleic acid molecules encoding them, as well as to their use as medicaments.
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公开(公告)号：EP3245223B1
公开(公告)日：2020-03-04
申请号：EP16700745.9
申请日：2016-01-15
申请人： BioNTech RNA Pharmaceuticals GmbH , Universität Stuttgart , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , GIESEKE, Friederike , BACKER, Ronald , KREITER, Sebastian , KONTERMANN, Roland , PFIZENMAIER, Klaus , FELLERMAIER, Sina , MÜLLER, Dafne
IPC分类号： A61K38/17 , C07K14/525 , C07K14/52
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公开(公告)号：EP3427723A1
公开(公告)日：2019-01-16
申请号：EP18171522.8
申请日：2013-03-25
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , HAAS, Heinrich , KREITER, Sebastian , DIKEN, Mustafa , FRITZ, Daniel , MENG, Martin , KRANZ, Lena Mareen , REUTER, Kerstin
摘要： The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.
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公开(公告)号：EP3881827A1
公开(公告)日：2021-09-22
申请号：EP21165536.0
申请日：2017-07-14
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GGMBH
发明人： SAHIN, Ugur , HAAS, Heinrich , VOGEL, Annette , ZUCKER, Daniel , ERBAR, Stephanie , REUTER, Kerstin , SCHLEGEL, Anne , HÖRNER, Sebastian , KREITER, Sebastian , DIKEN, Mustafa , MORENO HERRERO, Jorge
摘要： The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine. The RNA may encode a protein of interest, such as a pharmaceutically active protein. Furthermore, the present invention relates to pharmaceutical products, comprising said RNA polyplex formulations for parenteral application to humans or to animals. The present invention relates as well to manufacturing of such pharmaceutical products, comprising, optionally, steps of sterile filtration, freezing and dehydration.
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公开(公告)号：EP2714071B1
公开(公告)日：2019-07-10
申请号：EP12723117.3
申请日：2012-05-23
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
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公开(公告)号：EP3473267A1
公开(公告)日：2019-04-24
申请号：EP18199105.0
申请日：2012-05-23
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , KREITER, Sebastian , DIKEN, Mustafa , DIEKMANN, Jan , KOSLOWSKI, Michael , BRITTEN, Cedrik , CASTLE, John , LÖWER, Martin , RENARD, Bernhard , OMOKOKO, Tana , DE GRAAF, Johannes Hendrikus
摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.
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公开(公告)号：EP2830593B1
公开(公告)日：2019-02-27
申请号：EP13713356.7
申请日：2013-03-25
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
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公开(公告)号：EP3777840A1
公开(公告)日：2021-02-17
申请号：EP20189077.9
申请日：2013-03-25
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , HAAS, Heinrich , KREITER, Sebastian , DIKEN, Mustafa , FRITZ, Daniel , MENG, Martin , KRANZ, Lena Mareen , WALZER, Kerstin
摘要： The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.
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