-
公开(公告)号：EP3484445A1
公开(公告)日：2019-05-22
申请号：EP17743293.7
申请日：2017-07-14
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON-Translationale Onkologie an der Universitätsm Universitätsmedizin der Johannes Gutenberg- Universtität Mainz gGmbH
-
公开(公告)号：EP3881827A1
公开(公告)日：2021-09-22
申请号：EP21165536.0
申请日：2017-07-14
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GGMBH
发明人： SAHIN, Ugur , HAAS, Heinrich , VOGEL, Annette , ZUCKER, Daniel , ERBAR, Stephanie , REUTER, Kerstin , SCHLEGEL, Anne , HÖRNER, Sebastian , KREITER, Sebastian , DIKEN, Mustafa , MORENO HERRERO, Jorge
摘要： The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine. The RNA may encode a protein of interest, such as a pharmaceutically active protein. Furthermore, the present invention relates to pharmaceutical products, comprising said RNA polyplex formulations for parenteral application to humans or to animals. The present invention relates as well to manufacturing of such pharmaceutical products, comprising, optionally, steps of sterile filtration, freezing and dehydration.
-
公开(公告)号：EP3737386A1
公开(公告)日：2020-11-18
申请号：EP19701783.3
申请日：2019-01-10
申请人： BioNTech RNA Pharmaceuticals GmbH , Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg Universität Mainz gGmbH (TRON)
发明人： SAHIN, Ugur , HAAS, Heinrich , VOGEL, Annette , ERBAR, Stephanie , WALZER, Kerstin , SCHLEGEL, Anne , HÖRNER, Sebastian , MORENO HERRERO, Jorge , KLAMP, Thorsten , KREITER, Sebastian , DIKEN, Mustafa , HELLER, Phillip
IPC分类号： A61K31/7105 , A61K39/12 , A61K9/00 , C12N15/87
-
公开(公告)号：EP3858333A1
公开(公告)日：2021-08-04
申请号：EP21151194.4
申请日：2018-10-18
发明人： HAAS, Heinrich , HÖRNER, Sebastian , ESPARZA BORQUEZ, Isaac Hernan , HILLER, Thomas Michael , BATES, Ferdia
IPC分类号： A61K9/127 , A61K31/713 , A61K9/08 , A61K47/26
摘要： The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.
-
公开(公告)号：EP3697384A1
公开(公告)日：2020-08-26
申请号：EP18792901.3
申请日：2018-10-18
发明人： HAAS, Heinrich , HÖRNER, Sebastian , ESPARZA BORQUEZ, Isaac Hernan , HILLER, Thomas Michael , BATES, Ferdia
IPC分类号： A61K9/127 , A61K31/713
-
-
-
-
搜索结果
5 条记录 (耗时 0.015 秒)
