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公开(公告)号：EP3881827A1
公开(公告)日：2021-09-22
申请号：EP21165536.0
申请日：2017-07-14
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GGMBH
发明人： SAHIN, Ugur , HAAS, Heinrich , VOGEL, Annette , ZUCKER, Daniel , ERBAR, Stephanie , REUTER, Kerstin , SCHLEGEL, Anne , HÖRNER, Sebastian , KREITER, Sebastian , DIKEN, Mustafa , MORENO HERRERO, Jorge
摘要： The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine. The RNA may encode a protein of interest, such as a pharmaceutically active protein. Furthermore, the present invention relates to pharmaceutical products, comprising said RNA polyplex formulations for parenteral application to humans or to animals. The present invention relates as well to manufacturing of such pharmaceutical products, comprising, optionally, steps of sterile filtration, freezing and dehydration.
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公开(公告)号：EP3860656A1
公开(公告)日：2021-08-11
申请号：EP19780222.6
申请日：2019-09-30
发明人： BARZ, Matthias , WEBER, Benjamin , HAAS, Heinrich , HELLER, Philipp , NOGUEIRA, Sara , SCHLEGEL, Anne
IPC分类号： A61K47/34 , A61K48/00 , A61K31/195 , C07K1/06 , C08G69/10
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公开(公告)号：EP3427723A1
公开(公告)日：2019-01-16
申请号：EP18171522.8
申请日：2013-03-25
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , HAAS, Heinrich , KREITER, Sebastian , DIKEN, Mustafa , FRITZ, Daniel , MENG, Martin , KRANZ, Lena Mareen , REUTER, Kerstin
摘要： The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.
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公开(公告)号：EP3777840A1
公开(公告)日：2021-02-17
申请号：EP20189077.9
申请日：2013-03-25
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , HAAS, Heinrich , KREITER, Sebastian , DIKEN, Mustafa , FRITZ, Daniel , MENG, Martin , KRANZ, Lena Mareen , WALZER, Kerstin
摘要： The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.
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公开(公告)号：EP3737386A1
公开(公告)日：2020-11-18
申请号：EP19701783.3
申请日：2019-01-10
申请人： BioNTech RNA Pharmaceuticals GmbH , Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg Universität Mainz gGmbH (TRON)
发明人： SAHIN, Ugur , HAAS, Heinrich , VOGEL, Annette , ERBAR, Stephanie , WALZER, Kerstin , SCHLEGEL, Anne , HÖRNER, Sebastian , MORENO HERRERO, Jorge , KLAMP, Thorsten , KREITER, Sebastian , DIKEN, Mustafa , HELLER, Phillip
IPC分类号： A61K31/7105 , A61K39/12 , A61K9/00 , C12N15/87
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公开(公告)号：EP2830593B1
公开(公告)日：2019-02-27
申请号：EP13713356.7
申请日：2013-03-25
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
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公开(公告)号：EP3697384A1
公开(公告)日：2020-08-26
申请号：EP18792901.3
申请日：2018-10-18
发明人： HAAS, Heinrich , HÖRNER, Sebastian , ESPARZA BORQUEZ, Isaac Hernan , HILLER, Thomas Michael , BATES, Ferdia
IPC分类号： A61K9/127 , A61K31/713
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公开(公告)号：EP3427723B1
公开(公告)日：2020-08-05
申请号：EP18171522.8
申请日：2013-03-25
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
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公开(公告)号：EP3484445A1
公开(公告)日：2019-05-22
申请号：EP17743293.7
申请日：2017-07-14
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON-Translationale Onkologie an der Universitätsm Universitätsmedizin der Johannes Gutenberg- Universtität Mainz gGmbH
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10.发明公开LIPID PARTICLE FORMULATIONS FOR DELIVERY OF RNA AND WATER-SOLUBLE THERAPEUTICALLY EFFECTIVE COMPOUNDS TO A TARGET CELL 审中-公开用于将RNA和水可溶性治疗有效化合物递送至靶细胞的脂质颗粒制剂
公开(公告)号：EP3277263A1
公开(公告)日：2018-02-07
申请号：EP16712339.7
申请日：2016-03-30
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： HEFESHA, Hossam , SAHIN, Ugur , HAAS, Heinrich , KREITER, Sebastian , HÜSEMANN, Yves , DIKEN, Mustafa , REUTER, Kerstin
CPC分类号： A61K9/1075 , A61K9/0019 , A61K9/1272 , A61K31/663 , A61K31/675 , A61K31/7105 , A61K39/0011 , A61K39/395 , A61K45/06 , A61K47/186 , A61K47/24 , A61K48/00 , A61K2039/54 , A61P35/00 , A61K2300/00
摘要： The present invention relates to lipid particles comprising at least one cationic lipid, at least one water-soluble therapeutically effective compound and RNA. Further, the present invention relates to a pharmaceutical composition comprising such particles. Said pharmaceutical composition is useful for inducing an immune response. It is also useful in a prophylactic and/or therapeutic treatment of a disease involving an antigen. Furthermore, the present invention relates to a method for producing the particles.
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