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公开(公告)号：EP4162034A1
公开(公告)日：2023-04-12
申请号：EP21729331.5
申请日：2021-06-01
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： PERKOVIC, Mario , WITZEL, Sonja , BEISSERT, Tim , SAHIN, Ugur
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公开(公告)号：EP4126039A1
公开(公告)日：2023-02-08
申请号：EP21715268.5
申请日：2021-03-30
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3.发明公开
公开(公告)号：EP4408886A1
公开(公告)日：2024-08-07
申请号：EP22800119.4
申请日：2022-09-29
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公开(公告)号：EP3946425A1
公开(公告)日：2022-02-09
申请号：EP20718248.6
申请日：2020-04-02
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
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公开(公告)号：EP2920209B1
公开(公告)日：2020-08-05
申请号：EP13789492.9
申请日：2013-11-12
申请人： BioNTech SE , Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , STADLER, Christiane , HOLLAND, Julia , BÄHR-MAHMUD, Hayat , BEISSERT, Tim , PLUM, Laura , LE GALL, Fabrice , JENDRETZKI, Arne , FIEDLER, Markus
IPC分类号： C07K16/28
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公开(公告)号：EP4415750A1
公开(公告)日：2024-08-21
申请号：EP22802064.0
申请日：2022-10-10
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
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公开(公告)号：EP4415747A1
公开(公告)日：2024-08-21
申请号：EP22802066.5
申请日：2022-10-10
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , WEBER, David , WALTER, Carina , BAREA ROLDÁN, Diana , KUNER, Ruprecht , HEIN, Melanie , SUCHAN, Martin , KISSLER, Verena , KRANZ, Lena Mareen
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K39/001184 , A61K2039/515220130101 , A61K2039/515620130101
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公开(公告)号：EP4368702A2
公开(公告)日：2024-05-15
申请号：EP24165309.6
申请日：2018-09-11
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C12N5/074
CPC分类号： C07K14/005 , C12N5/0696 , C12N2501/0020130101 , C12N2760/1202220130101 , C12N2501/60220130101 , C12N2501/60320130101 , C12N2501/60420130101 , C12N2501/60520130101 , C12N2501/60620130101 , C12N2501/60820130101 , C12N2501/6520130101 , C12N2510/0020130101 , Y02A50/30
摘要： The present invention describes a virus-derived factor which when provided to cells, e.g., by transfecting the cells with RNA encoding the virus-derived factor, enhances expression of RNA encoding a peptide or protein in the cells. In particular, the virus-derived factor enhances survival of cells, in particular when transfected repetitively with RNA, and reduces an IFN response of cells to transfected RNA. Accordingly, the present invention provides methods and means for enhancing expression of RNA in cells. The cells are preferably transfected with the RNA.
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公开(公告)号：EP4241786A3
公开(公告)日：2023-12-27
申请号：EP23172071.5
申请日：2018-03-21
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： BIHI, Mahjoub , SAHIN, Ugur , DIKEN, Mustafa , KLAMP, Thorsten
IPC分类号： A61K39/00
摘要： The present invention relates to methods and compositions for stimulating an immune response. In particular, the present invention relates to immunostimulatory RNA molecules comprising sequences derived from an Influenza A virus nucleoprotein-encoding RNA molecule that act as adjuvants and/or immunostimulatory agents to enhance host immune responses.
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公开(公告)号：EP4241786A2
公开(公告)日：2023-09-13
申请号：EP23172071.5
申请日：2018-03-21
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： BIHI, Mahjoub , SAHIN, Ugur , DIKEN, Mustafa , KLAMP, Thorsten
IPC分类号： A61K39/00
摘要： The present invention relates to methods and compositions for stimulating an immune response. In particular, the present invention relates to immunostimulatory RNA molecules comprising sequences derived from an Influenza A virus nucleoprotein-encoding RNA molecule that act as adjuvants and/or immunostimulatory agents to enhance host immune responses.
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