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1.发明公开A METHOD OF NUCLEIC ACID TYPING FOR SELECTING REGISTERED DONORS FOR CROSS-MATCHING TO TRANSFUSION RECIPIENTS 有权对于核酸分型方法的选择登记捐助者CROSS样本输血RECEIVERS
公开(公告)号：EP1805326A2
公开(公告)日：2007-07-11
申请号：EP05816073.0
申请日：2005-10-24
发明人： SEUL, Michael , HASHMI, Ghazala , PIERCE, Michael
CPC分类号： C12Q1/6881 , C12Q2600/156 , C12Q2600/16
摘要： Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes-and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.
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2.发明授权A METHOD OF NUCLEIC ACID TYPING FOR SELECTING REGISTERED DONORS FOR CROSS-MATCHING TO TRANSFUSION RECIPIENTS 有权对于核酸分型方法的选择登记捐助者CROSS样本输血RECEIVERS
公开(公告)号：EP1805326B1
公开(公告)日：2014-12-17
申请号：EP05816073.0
申请日：2005-10-24
CPC分类号： C12Q1/6881 , C12Q2600/156 , C12Q2600/16
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3.发明授权
公开(公告)号：EP1463825B1
公开(公告)日：2017-12-06
申请号：EP02801745.7
申请日：2002-10-15
发明人： LI, Alice, Xiang , HASHMI, Ghazala , SEUL, Michael
CPC分类号： C12Q1/6827 , C12Q1/6837 , C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , C12Q2565/537 , C12Q2535/125 , C12Q2527/107
摘要： The invention provides methods and processes for the identification of polymorphisms at one or more designated sites, without interference from non-designated sites located within proximity of such designated sites. Probes are provided capable of interrogation of such designated sites in order to determine the composition of each such designated site. By the methods of this invention, one or more mutations within the CFTR gene and the HLA gene complex can be identified.
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公开(公告)号：EP1543163B1
公开(公告)日：2014-08-27
申请号：EP03794568.0
申请日：2003-09-04
发明人： HASHMI, Ghazala , SEUL, Michael , MESSING, Joachim
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
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公开(公告)号：EP1543163A2
公开(公告)日：2005-06-22
申请号：EP03794568.0
申请日：2003-09-04
发明人： HASHMI, Ghazala , SEUL, Michael , MESSING, Joachim
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
摘要： This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The marders may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
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6.发明公开
公开(公告)号：EP1463825A2
公开(公告)日：2004-10-06
申请号：EP02801745.7
申请日：2002-10-15
发明人： LI, Alice, Xiang , HASHMI, Ghazala , SEUL, Michael
CPC分类号： C12Q1/6827 , C12Q1/6837 , C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , C12Q2565/537 , C12Q2535/125 , C12Q2527/107
摘要： The invention provides methods and processes for the identification of polymorphisms at one or more designated sites, without interference from non-designated sites located within proximity of such designated sites. Probes are provided capable of interrogation of such designated sites in order to determine the composition of each such designated site. By the methods of this invention, one or more mutations within the CFTR gene and the HLA gene complex can be identified.
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