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公开(公告)号：EP1594628B1
公开(公告)日：2013-06-26
申请号：EP04703983.9
申请日：2004-01-21
IPC分类号： C08J3/215
CPC分类号： C08J3/212 , C08J3/215 , C08J3/22 , C08J2325/08
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2.发明公开A METHOD OF NUCLEIC ACID TYPING FOR SELECTING REGISTERED DONORS FOR CROSS-MATCHING TO TRANSFUSION RECIPIENTS 有权对于核酸分型方法的选择登记捐助者CROSS样本输血RECEIVERS
公开(公告)号：EP1805326A2
公开(公告)日：2007-07-11
申请号：EP05816073.0
申请日：2005-10-24
发明人： SEUL, Michael , HASHMI, Ghazala , PIERCE, Michael
CPC分类号： C12Q1/6881 , C12Q2600/156 , C12Q2600/16
摘要： Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes-and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.
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3.发明授权
公开(公告)号：EP1463825B1
公开(公告)日：2017-12-06
申请号：EP02801745.7
申请日：2002-10-15
发明人： LI, Alice, Xiang , HASHMI, Ghazala , SEUL, Michael
CPC分类号： C12Q1/6827 , C12Q1/6837 , C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , C12Q2565/537 , C12Q2535/125 , C12Q2527/107
摘要： The invention provides methods and processes for the identification of polymorphisms at one or more designated sites, without interference from non-designated sites located within proximity of such designated sites. Probes are provided capable of interrogation of such designated sites in order to determine the composition of each such designated site. By the methods of this invention, one or more mutations within the CFTR gene and the HLA gene complex can be identified.
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公开(公告)号：EP1543163B1
公开(公告)日：2014-08-27
申请号：EP03794568.0
申请日：2003-09-04
发明人： HASHMI, Ghazala , SEUL, Michael , MESSING, Joachim
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
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5.发明授权COLOR-ENCODING AND IN-SITU INTERROGATION OF MATRIX-COUPLED CHEMICAL COMPOUNDS 失效颜色编码及原位讯问MATRIX耦合化学化合物
公开(公告)号：EP1003904B1
公开(公告)日：2007-07-11
申请号：EP98923786.2
申请日：1998-05-22
IPC分类号： C12Q1/00 , C12Q1/68 , G01N21/00 , G01N21/76 , G01N33/53 , G01N33/533 , G01N33/543 , G01N33/566 , C07B61/00 , B01J19/00 , G01N33/68
CPC分类号： C40B20/04 , B01J19/0046 , B01J2219/00459 , B01J2219/005 , B01J2219/00545 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , C40B30/04 , C40B40/06 , C40B40/10 , C40B50/04 , C40B50/16 , C40B70/00 , G01N21/29 , G01N21/64 , G01N21/6458 , G01N33/54313 , G01N33/582 , G01N33/6845 , G01N2021/1765
摘要： A method and apparatus for the physico-chemical encoding of a collection of beaded resin ("beads") to determine the chemical identity of bead-anchored compounds by in-situ interrogation of individual beads. The present invention provides method and apparatus to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial compounds libraries as well as multiplexed diagnostic and environmental testing and other biochemical assays.
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6.发明公开MULTIANALYTE MOLECULAR ANALYSIS USING APPLICATION−SPECIFIC RANDOM PARTICLE ARRAYS 审中-公开多媒体多媒体广播电视节目VON ANWENDUNGSSPEZIFISCHEN STATISTISCHEN TEILCHENANORDNUNGEN
公开(公告)号：EP1461355A2
公开(公告)日：2004-09-29
申请号：EP02796094.7
申请日：2002-12-27
发明人： BANERJEE, Sukanta , SEUL, Michael
IPC分类号： C07K1/04 , C12Q1/00 , C12Q1/68 , G01N21/00 , G01N33/533 , G01N33/543
CPC分类号： G01N33/5434 , B01J19/0046 , B01J2219/005 , B01J2219/00545 , B01J2219/00576 , B82Y15/00 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/54326 , G01N33/54333 , G01N33/54346 , G01N33/587 , G01N33/588
摘要： The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译： 本发明提供了一种通过产生磁性纳米颗粒和编码颗粒的新型亚文库从子文库产生编码磁性颗粒的新文库的方法。 子库根据需要进行功能化在数组的形成中是有用的。 本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。
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公开(公告)号：EP1594628A2
公开(公告)日：2005-11-16
申请号：EP04703983.9
申请日：2004-01-21
IPC分类号： B05D7/00
CPC分类号： C08J3/212 , C08J3/215 , C08J3/22 , C08J2325/08
摘要： Solute-loaded polymer microparticles are obtained by immersing microparticles in a bath comprising a selected solute dissolved in a ternary solvent system. A first solvent of the ternary system is a strong solvent for both the solute and the polymer from which the microparticle was formed. A second solvent is a weak solvent or non- solvent for the solute and the polymer (tuning solvent). A third solvent is a weak solvent or non-solvent for the solute and polymer, but serves as a co-solvent with respect to the first and second solvents in that it is miscible with both the first and second solvents. The amount of solute incorporated into the microparticles is controlled by adjusting the ratio of solute with respect to the microparticle polymer, and by adjusting the composition of the ternary solvent system, principally the amount of tuning solvent. The method is particularly useful for providing libraries of combinatorially encoded microparticles containing distinguishable dye loadings, particularly distinguishable fluorescent dye loadings.
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公开(公告)号：EP1379323A1
公开(公告)日：2004-01-14
申请号：EP02725284.0
申请日：2002-03-21
IPC分类号： B01D57/02 , B01D59/42 , B01D59/50 , B01D61/58 , C02F1/469 , C08F2/58 , C25B15/00 , C25B7/00 , G01F1/64 , G01L1/20 , G01L9/18 , G01N27/26
CPC分类号： G01N15/0266 , B03C5/026 , C02F1/469 , G01N2015/0294
摘要： A method and apparatus for fractionation of a mixture of particles and for particle analysis are provided, in which LEAPS ('Light-controlled Electrokinetic Assembly of Particles near Surfaces') is used to fractionate and analyze a plurality of particles suspended in an interface between an electrode and an electrolyte solution. A mixture of particles are fractionated according to their relaxation frequencies, which in turn reflect differences in size or surface composition of the particles. Particles may also be analyzed to determine their physical and chemical properties based on particle relaxation frequency and maximal velocity.
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9.发明授权AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TRAGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION 有权AUTOMATED交互模式分析复用器样品取样目标和比较ALLELIDENTIFIKATION
公开(公告)号：EP1774323B1
公开(公告)日：2016-03-02
申请号：EP05789862.9
申请日：2005-08-02
发明人： XIONGWU, Xia , SEUL, Michael
CPC分类号： C12Q1/6827 , G06F19/18 , G06F19/22
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10.发明授权MESSAGE ABUNDANCE AND ALLELE COPY NUMBER DETERMINATION USING IVT WITH SINGLE-STRANDED PRIMER-PROMOTER-SELECTOR CONSTRUCTS 有权发布频率的决心，通过单链引物启动子选择器构建ALLELKOPIENZAHL使用IVT
公开(公告)号：EP1926835B1
公开(公告)日：2014-12-31
申请号：EP06815137.2
申请日：2006-09-21
发明人： SEUL, Michael , KORZHEVA, Nataliya
IPC分类号： C12N15/10
CPC分类号： C12Q1/6837 , C12N15/1096 , C12Q1/6858 , C12Q1/6865 , C12Q1/6876 , C12Q2521/107 , C12Q2525/143 , C12Q2563/179 , C12Q2565/137 , C12Q2545/114 , C12Q2531/113
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