公开(公告)号：EP1421364A1

公开(公告)日：2004-05-26

申请号：EP02791516.4

申请日：2002-08-02

申请人： Biocytex

发明人： CANTON, Michel

IPC分类号： G01N15/14

CPC分类号： G01N15/1436 ,  G01N15/1484

摘要： The invention concerns a device for analysing a sample comprising a sample receptacle (8) and a mirror (38), the mirror (38) comprising a break (40) such that a light beam (42) can pass through the mirror to reach the receptacle (8). The invention also concerns an assembly for analysing a sample comprising a device (2) and an equipment having a removable housing for receiving the device and a light source, the source being adapted to emit a light beam (42) passing through the mirror (38) to reach the receptacle (8) when the device is in the housing.

公开(公告)号：EP1282817B1

公开(公告)日：2005-04-27

申请号：EP01936518.8

申请日：2001-05-15

申请人： Biocytex

发明人： CANTON, Michel ,  BOTOSEZZY, Isabelle

IPC分类号： G01N33/533 ,  G01N33/86 ,  G01N15/10

CPC分类号： G01N33/56966 ,  G01N33/80 ,  G01N33/86 ,  G01N2015/0084 ,  G01N2015/1018

摘要： The invention concerns a monoreagent and a diagnostic kit for detecting and quantifying platelet-derived microparticles (MPP). Said monoreagent, combining several populations of calibrated beads and a double labelling of MPP, enables both an optimal isolation of MPP based on a size criterion, their characterisation by specific labels, and their numbering with counting beads.

公开(公告)号：EP1192443A1

公开(公告)日：2002-04-03

申请号：EP00948067.4

申请日：2000-06-30

申请人： Biocytex

发明人： CANTON, Michel ,  DIGNAT-GEORGE, Françoise

IPC分类号： G01N15/14 ,  G01N33/569

CPC分类号： G01N33/585 ,  G01N33/56966 ,  G01N2015/1006 ,  G01N2015/1018 ,  G01N2015/1062

摘要： The invention concerns a monoreagent and a diagnosis kit comprising same for the detection and quantitation of microparticles of endothelial origin in a plasma sample by flow cytometry. The monoreagent comprises a mixture of monoclonal antibodies specific of endothelial cell membrane molecules, said mixture comprising an antibody (1) marked with a fluorochrome 1 and an antibody (2) marked with a fluorochrome 2, said antibodies (1) and (2) not having the same specificity and four populations of microspheres for respectively defining the analysis region, the minimum intensity threshold and enabling the microparticles to be counted. The invention also concerns a method for the quantitation of microparticles of endothelial origin using said monoreagent and kit.

公开(公告)号：EP1192443B1

公开(公告)日：2003-05-02

申请号：EP00948067.4

申请日：2000-06-30

申请人： Biocytex

发明人： CANTON, Michel ,  DIGNAT-GEORGE, Françoise

IPC分类号： G01N15/14 ,  G01N33/569

CPC分类号： G01N33/585 ,  G01N33/56966 ,  G01N2015/1006 ,  G01N2015/1018 ,  G01N2015/1062

公开(公告)号：EP0920628B1

公开(公告)日：2001-12-05

申请号：EP98929487.1

申请日：1998-06-04

申请人： Biocytex

发明人： BESSON-FAURE, Isabelle ,  CANTON, Michel

IPC分类号： G01N33/566 ,  G01N33/86

CPC分类号： G01N33/566 ,  G01N33/86 ,  G01N2333/70546 ,  G01N2333/75

摘要： The invention concerns a method for determining on a sample to be tested the occupation of the GPIIb/IIIa platelet receptors by the fibrinogen antagonist, characterised in that it consists in determining in said sample the number of occupied receptors by means of a MAb1 antibody competitor of the antagonist and the number of total receptors occupied or not by means of a antibody specific of the receptor whether it is occupied or not, MAb2 said to be non-competitor and deducing therefrom the occupation rate of GPIIb/IIIa receptors in the sample.

公开(公告)号：EP1627227A1

公开(公告)日：2006-02-22

申请号：EP04767185.4

申请日：2004-05-26

申请人： Biocytex

发明人： HAQUETTE, Guillaume ,  PONCELET, Philippe ,  MOULARD, Maxime ,  CANTON, Michel

IPC分类号： G01N33/543

CPC分类号： G01N33/54333

摘要： The invention relates to a method for the detection and multiplex quantification of analytes in a sample, using functionalised microspheres, whereby said microspheres are magnetised after the sample has been brought into contact therewith. The inventive method is particularly suitable for the detection and multiplex quantification of several analytes by means of flow cytometry. The invention also relates to a kit which is used for the detection and/or quantification of several analytes in order to carry out the inventive method, comprising a suspension of functionalised non-magnetic microspheres, a ferrofluid solution and a solution with at least one conjugate.

公开(公告)号：EP1282817A1

公开(公告)日：2003-02-12

申请号：EP01936518.8

申请日：2001-05-15

申请人： Biocytex

发明人： CANTON, Michel ,  BOTOSEZZY, Isabelle

IPC分类号： G01N33/533 ,  G01N33/86 ,  G01N15/10

CPC分类号： G01N33/56966 ,  G01N33/80 ,  G01N33/86 ,  G01N2015/0084 ,  G01N2015/1018

摘要： The invention concerns a monoreagent and a diagnostic kit for detecting and quantifying platelet-derived microparticles (MPP). Said monoreagent, combining several populations of calibrated beads and a double labelling of MPP, enables both an optimal isolation of MPP based on a size criterion, their characterisation by specific labels, and their numbering with counting beads.

公开(公告)号：EP0920628A1

公开(公告)日：1999-06-09

申请号：EP98929487.0

申请日：1998-06-04

申请人： Biocytex

发明人： BESSON-FAURE, Isabelle ,  CANTON, Michel

IPC分类号： C07K16 ,  G01N33

CPC分类号： G01N33/566 ,  G01N33/86 ,  G01N2333/70546 ,  G01N2333/75

摘要： The invention concerns a method for determining on a sample to be tested the occupation of the GPIIb/IIIa platelet receptors by the fibrinogen antagonist, characterised in that it consists in determining in said sample the number of occupied receptors by means of a MAb1 antibody competitor of the antagonist and the number of total receptors occupied or not by means of a antibody specific of the receptor whether it is occupied or not, MAb2 said to be non-competitor and deducing therefrom the occupation rate of GPIIb/IIIa receptors in the sample.