公开(公告)号：EP1624858A2

公开(公告)日：2006-02-15

申请号：EP04759375.1

申请日：2004-04-09

申请人： Biodelivery Sciences International, Inc. ,  UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY

发明人： MANNINO, Raphael, J. ,  GOULD-FOGERITE, Susan ,  KRAUSE-ELSMORE, Sara, L. ,  DELMARRE, David ,  LU, Ruying

IPC分类号： A61K9/127

CPC分类号： A61K9/1277 ,  A61K9/1274 ,  A61K31/00 ,  A61K31/135 ,  A61K31/167 ,  A61K31/395 ,  A61K31/60 ,  A61K31/7036 ,  A61K31/7048 ,  A61K38/12 ,  A61K38/14 ,  G01N33/5091

摘要： Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.

公开(公告)号：EP2704688A1

公开(公告)日：2014-03-12

申请号：EP12779548.2

申请日：2012-05-04

申请人： Coordinated Program Development, LLC ,  University Of Medicine And Dentistry Of New Jersey

发明人： LU, Ruying ,  MANNINO, Raphael

IPC分类号： A61K9/00 ,  A61K31/70 ,  A61K38/02 ,  A61K39/00 ,  A61K31/7048 ,  A61K31/704 ,  A61K39/13 ,  A61K31/472 ,  A61K31/496 ,  A61K47/12 ,  A61K31/07 ,  A61K39/145 ,  A61K31/20 ,  A61K33/30 ,  A61K33/26 ,  A61K33/00 ,  A61K36/54

CPC分类号： A61K9/1274 ,  A61K31/07 ,  A61K31/20 ,  A61K31/472 ,  A61K31/496 ,  A61K31/70 ,  A61K31/7036 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/14 ,  A61K39/12 ,  A61K39/145 ,  A61K39/39 ,  A61K47/02 ,  A61K47/24 ,  A61K2039/53 ,  A61K2039/542 ,  A61K2039/55555 ,  C12N2740/16034 ,  C12N2760/16143 ,  A61K2300/00

摘要： The present invention provides, in part, cochleate compositions and methods for making and using same.