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1.发明授权Clotting factor chimeric proteins for treatment of a hemostatic disorder 有权ChimäreProteine mit Gerinnungsfaktor zur Behandlung vonhämostatischenErkrankungen
公开(公告)号：EP2298347B1
公开(公告)日：2015-09-30
申请号：EP10184851.3
申请日：2004-05-06
CPC分类号： C12N9/6437 , A61K38/36 , A61K38/4846 , A61K45/06 , A61K47/6815 , A61K47/6835 , A61K2039/60 , C07K14/745 , C07K16/18 , C07K2319/30 , C12N9/644 , C12N9/6454 , C12Y304/21021 , C12Y304/21022
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公开(公告)号：EP2361932B1
公开(公告)日：2016-05-04
申请号：EP10182890.3
申请日：2004-05-06
发明人： Peters, Robert T. , Mezo, Adam R , Rivera, Daniel S , Bitonti, Alan J , Stattel, James M , Low, Susan C
IPC分类号： C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/475 , C07K16/00 , C12N9/64 , C12N9/96 , A61K47/48
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： A chimeric protein is synthesized by a) recombinantly expressing a fusion protein comprising at least a portion of an immunoglobulin constant region and a splicing protein capable of forming a C terminus thioester on the portion of an immunoglobulin constant region; b) adding a thiol cofactor to the fusion protein of a); and c) adding at least one biologically active molecule having an N terminal cysteine.
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公开(公告)号：EP2357196B1
公开(公告)日：2016-05-04
申请号：EP10182902.6
申请日：2004-05-06
发明人： Peters, Robert T. , Mezo, Adam R , Rivera, Daniel S , Bitoni, Alan J , Stattel, James M , Low, Susan C
IPC分类号： C07K14/505 , A61K47/48 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/475 , C07K16/00 , C12N9/64 , C12N9/96
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： A chimeric protein is synthesized by a) recombinantly expressing a fusion protein comprising at least a portion of an immunoglobulin constant region and a splicing protein capable of forming a C terminus thioester on the portion of an immunoglobulin constant region; b) adding a thiol cofactor to the fusion protein of a); and c) adding at least one biologically active molecule having an N terminal cysteine.
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4.发明公开CLOTTING FACTOR-FC CHIMERIC PROTEINS TO TREAT HEMOPHILIA 审中-公开CHIMÄRE蛋白棉GERINNUNGSFAKTOR FC ZUR BEHANDLUNG VONHÄMOPHILIE
公开(公告)号：EP3002012A9
公开(公告)日：2016-11-16
申请号：EP15178740.5
申请日：2004-05-06
IPC分类号： A61K39/395 , C12P21/08 , A61K38/36 , A61K47/48 , C07K14/745 , C07K16/18 , A61K45/06 , C12N9/64 , A61K39/00
CPC分类号： C12N9/6437 , A61K38/36 , A61K38/4846 , A61K45/06 , A61K47/6815 , A61K47/6835 , A61K2039/60 , C07K14/745 , C07K16/18 , C07K2319/30 , C12N9/644 , C12N9/6454 , C12Y304/21021 , C12Y304/21022
摘要： A pharmaceutical composition, for treatment of a hemostatic disorder, comprises a chimeric protein and a pharmaceutically acceptable carrier or excipient, wherein said chimeric protein comprises at least a portion of an immunoglobulin constant region which is an FcRn binding partner, a clotting factor selected from Factor VII. a Factor VII analog, Factor VIIa and a Factor VIIa analog, and optionally at least one linker.
摘要翻译： 用于治疗止血障碍的药物组合物包含嵌合蛋白质和药学上可接受的载体或赋形剂，其中所述嵌合蛋白质包含至少一部分免疫球蛋白恒定区，其是FcRn结合配偶体，凝血因子选自因子 VII，因子VII类似物，因子VIIa和因子VIIa类似物，以及任选的至少一个接头。
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公开(公告)号：EP2357196B9
公开(公告)日：2016-10-05
申请号：EP10182902.6
申请日：2004-05-06
发明人： Peters, Robert T. , Mezo, Adam R , Rivera, Daniel S , Bitoni, Alan J , Stattel, James M , Low, Susan C
IPC分类号： C07K14/505 , A61K47/48 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/475 , C07K16/00 , C12N9/64 , C12N9/96
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： A chimeric protein is synthesized by a) recombinantly expressing a fusion protein comprising at least a portion of an immunoglobulin constant region and a splicing protein capable of forming a C terminus thioester on the portion of an immunoglobulin constant region; b) adding a thiol cofactor to the fusion protein of a); and c) adding at least one biologically active molecule having an N terminal cysteine.
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6.发明授权
公开(公告)号：EP2174946B1
公开(公告)日：2016-07-06
申请号：EP09013214.3
申请日：2004-05-06
发明人： Mezo, Adam R. , Peters, Robert T.
IPC分类号： A61K47/48 , C07K14/505 , C07K14/555 , C12N9/64 , C12N9/96 , C07K14/475 , C07K14/56 , C07K14/745 , C07K16/00 , C07K14/565
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： A chimeric protein is synthesized by a) recombinantly expressing a fusion protein comprising at least a portion of an immunoglobulin constant region and a splicing protein capable of forming a C terminus thioester on the portion of an immunoglobulin constant region; b) adding a thiol cofactor to the fusion protein of a); and c) adding at least one biologically active molecule having an N terminal cysteine.
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公开(公告)号：EP3002012A1
公开(公告)日：2016-04-06
申请号：EP15178740.5
申请日：2004-05-06
IPC分类号： A61K39/395 , C12P21/08 , A61K38/36 , A61K47/48 , C07K14/745 , C07K16/18 , A61K45/06 , C12N9/64 , A61K39/00
CPC分类号： C12N9/6437 , A61K38/36 , A61K38/4846 , A61K45/06 , A61K47/6815 , A61K47/6835 , A61K2039/60 , C07K14/745 , C07K16/18 , C07K2319/30 , C12N9/644 , C12N9/6454 , C12Y304/21021 , C12Y304/21022
摘要： A pharmaceutical composition, for treatment of a hemostatic disorder, comprises a chimeric protein and a pharmaceutically acceptable carrier or excipient, wherein said chimeric protein comprises at least a portion of an immunoglobulin constant region which is an FcRn binding partner, a clotting factor selected from Factor VII. a Factor VII analog, Factor VIIa and a Factor VIIa analog, and optionally at least one linker.
摘要翻译： 用于治疗止血障碍的药物组合物包含嵌合蛋白和药学上可接受的载体或赋形剂，其中所述嵌合蛋白包含至少一部分为FcRn结合伴侣的免疫球蛋白恒定区，凝血因子选自因子 七。 因子VII类似物，因子VIIa和因子VIIa类似物，以及任选地至少一个接头。
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公开(公告)号：EP3103809A1
公开(公告)日：2016-12-14
申请号：EP16167345.4
申请日：2004-05-06
发明人： Peters, Robert T. , Mezo, Adam R , Rivera, Daniel S , Bitonti, Alan J. , Stattel, James M , Low, Susan C
IPC分类号： C07K16/00 , A61K47/48 , C07K14/505 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/475 , C07K14/555 , C12N9/64 , C12N9/96
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
摘要翻译： 本发明涉及嵌合单体二聚体杂交蛋白，其中所述蛋白质包含第一和第二多肽链，所述第一多肽链包含至少一部分免疫球蛋白恒定区和生物活性分子，所述第二多肽链包含 至少一部分没有第一链的生物活性分子的免疫球蛋白恒定区。 本发明还涉及制备本发明的嵌合单体 - 二聚体杂交蛋白质的方法和方法。
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