公开(公告)号：EP2740744B1

公开(公告)日：2018-03-28

申请号：EP14154372.8

申请日：2008-01-09

申请人： Biogen MA Inc.

发明人： Mi, Sha ,  Pepinsky, R. Blake ,  Shao, Zhaohui ,  Garber Stark, Ellen A. ,  Miklasz, Steven D. ,  Graff, Christilyn

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P25/00 ,  A61K31/70 ,  A61K38/16 ,  C07K14/00 ,  C07K16/00 ,  C07H21/00 ,  C12N15/13 ,  C12N5/20 ,  C12N15/113

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such as anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present disclosure provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The disclosure further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The disclosure further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.

公开(公告)号：EP2902491A1

公开(公告)日：2015-08-05

申请号：EP15160028.5

申请日：2004-03-17

申请人： Biogen MA Inc.

发明人： Mi, Sha ,  McCoy, John ,  Pepinsky, R. Blake ,  Lee, Daniel H. S. ,  Lugovskoy, Alexey A.

IPC分类号： C12N15/12 ,  C12N15/62 ,  C12N15/63 ,  C07K14/47 ,  C07K16/18 ,  A61K38/17 ,  A61K39/395 ,  A61K48/00 ,  G01N33/68 ,  G01N33/50 ,  C07K14/705 ,  C07K16/28 ,  A61K38/00

CPC分类号： G01N33/56966 ,  A61K38/00 ,  C07K14/4702 ,  C07K14/70571 ,  C07K16/18 ,  C07K16/2803 ,  C07K2319/30 ,  C12N5/0619 ,  C12N2500/46 ,  G01N33/5058 ,  G01N33/6896

摘要： The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof.

摘要翻译： 本发明提供了Sp35多肽及其融合蛋白，Sp35抗体及其抗原结合片段及其编码的核酸。 本发明还提供了包含以及其制备和使用此类Sp35抗体，其抗原结合片段，Sp35多肽及其融合蛋白的组合物。