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公开(公告)号：EP4273160A2
公开(公告)日：2023-11-08
申请号：EP23185472.0
申请日：2016-05-09
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C07K14/725
摘要： The present invention generally embraces the treatment of diseases by targeting cells expressing an antigen on the cell surface. In particular the invention relates to a method for stimulating, priming and/or expanding in vivo T cells genetically modified to express a chimeric antigen receptor (CAR) targeted to an antigen, comprising contacting the T cells with the antigen or a variant thereof in vivo. In one embodiment, the antigen or variant thereof is provided by administering a nucleic acid encoding the antigen or variant thereof.
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公开(公告)号：EP3213765A2
公开(公告)日：2017-09-06
申请号：EP17165403.1
申请日：2011-09-19
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana
IPC分类号： A61K39/00 , C07K14/705 , C07K14/47 , C07K14/045
CPC分类号： A61K39/0011 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/7051 , C12N5/0636 , C12N9/16 , C12N15/85 , C12N2510/00 , C12N2710/16134 , C12Y301/03048 , G01N33/5017 , G01N2333/916
摘要： The present invention relates to efficient methods for providing antigen- specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.
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公开(公告)号：EP3514172B1
公开(公告)日：2020-03-11
申请号：EP19151238.3
申请日：2015-03-30
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , Ganymed Pharmaceuticals GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana , HOFF, Holger , VOSS, Ralf-Holger , BREITKREUZ, Andrea , HOBOHM, Kathleen , MROZ, Karolina Anna
IPC分类号： C07K14/725 , C07K14/47 , A61P35/00 , A61K35/26
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公开(公告)号：EP3213765B1
公开(公告)日：2019-08-28
申请号：EP17165403.1
申请日：2011-09-19
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana
IPC分类号： A61K39/00 , C07K14/705 , C07K14/47 , C07K14/045
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公开(公告)号：EP3514172A1
公开(公告)日：2019-07-24
申请号：EP19151238.3
申请日：2015-03-30
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , Ganymed Pharmaceuticals GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana , HOFF, Holger , VOSS, Ralf-Holger , BREITKREUZ, Andrea , HOBOHM, Kathleen , MROZ, Karolina Anna
IPC分类号： C07K14/725 , C07K14/47 , A61P35/00 , A61K35/26
摘要： The present invention provides Claudin-6-specific immunoreceptors (T cell receptors and artificial T cell receptors (chimeric antigen receptors; CARs)) and T cell epitopes which are useful for immunotherapy.
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公开(公告)号：EP2618835B1
公开(公告)日：2017-07-05
申请号：EP11761508.8
申请日：2011-09-19
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana
IPC分类号： A61K39/00 , C07K14/705 , C07K14/47 , C07K14/045
CPC分类号： A61K39/0011 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/7051 , C12N5/0636 , C12N9/16 , C12N15/85 , C12N2510/00 , C12N2710/16134 , C12Y301/03048 , G01N33/5017 , G01N2333/916
摘要： The present invention relates to efficient methods for providing antigen- specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.
摘要翻译： 本发明涉及提供抗原特异性淋巴细胞的有效方法。 这些淋巴细胞可用于提供具有限定的MHC限制的抗原特异性T细胞受体并鉴定免疫学相关的T细胞表位。 此外，本发明涉及抗原特异性T细胞受体和T细胞表位及其在免疫治疗中的用途。
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7.发明公开
公开(公告)号：EP4082565A1
公开(公告)日：2022-11-02
申请号：EP22166898.1
申请日：2016-05-09
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana , BREITKREUZ, Andrea , MROZ, Karolina Anna , HEBICH, Lisa
IPC分类号： A61K39/00 , A61P35/00 , A61P37/04 , C07K7/06 , C07K14/725 , C07K16/28 , C07K14/705
摘要： The present invention provides Claudin-18.2-specific immunoreceptors (T cell receptors and artificial T cell receptors (chimeric antigen receptors; CARs)) and T cell epitopes which are useful for immunotherapy.
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公开(公告)号：EP3590530A1
公开(公告)日：2020-01-08
申请号：EP19193391.0
申请日：2011-09-19
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana
IPC分类号： A61K39/00 , C07K14/705 , C07K14/47 , C07K14/045
摘要： The present invention relates to efficient methods for providing antigen- specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.
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公开(公告)号：EP3359563A1
公开(公告)日：2018-08-15
申请号：EP16777681.4
申请日：2016-10-05
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C07K14/725 , C07K16/28
CPC分类号： C07K14/7051 , A61K2039/5156 , A61K2039/585 , C07K16/28 , C07K16/30 , C07K2317/35 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/622 , C07K2317/74 , C07K2319/33
摘要： The present invention generally embraces the treatment of diseases by targeting cells expressing an antigen on the cell surface. In particular the invention relates to recombinant antigen receptors and uses thereof. T cells engineered to express such antigen receptors are useful in the treatment of diseases characterized by expression of one or more antigens bound by the antigen receptors.
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公开(公告)号：EP4273160A3
公开(公告)日：2024-04-24
申请号：EP23185472.0
申请日：2016-05-09
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： A61K39/00 , A61K35/17 , C07K14/725
CPC分类号： A61K39/0011 , C07K14/7051 , A61K2039/5320130101 , A61K9/127 , A61K39/39558 , C07K16/28 , C07K2317/62220130101 , C07K2319/0320130101 , A61K35/17 , A61P35/00 , A61P37/04 , A61P43/00 , A61K39/001112 , A61K39/001124 , A61K39/00111 , A61K39/001113 , A61K39/001182 , A61K39/001188 , A61K39/001168 , A61K39/001195 , A61K2239/3820230501 , A61K39/464412 , C12N5/0636 , A61K39/001102 , A61K39/4631 , A61K2239/4820230501 , A61K2239/1720230501 , A61K39/464402 , A61K2239/3120230501 , A61K2239/2220230501 , A61K39/4611
摘要： The present invention generally embraces the treatment of diseases by targeting cells expressing an antigen on the cell surface. In particular the invention relates to a method for stimulating, priming and/or expanding in vivo T cells genetically modified to express a chimeric antigen receptor (CAR) targeted to an antigen, comprising contacting the T cells with the antigen or a variant thereof in vivo. In one embodiment, the antigen or variant thereof is provided by administering a nucleic acid encoding the antigen or variant thereof.
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