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公开(公告)号：EP4376875A1
公开(公告)日：2024-06-05
申请号：EP22761067.2
申请日：2022-07-28
申请人： BioNTech SE
IPC分类号： A61K39/00 , A61K39/395 , A61P35/00 , C07K16/28
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公开(公告)号：EP4273160A3
公开(公告)日：2024-04-24
申请号：EP23185472.0
申请日：2016-05-09
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： A61K39/00 , A61K35/17 , C07K14/725
CPC分类号： A61K39/0011 , C07K14/7051 , A61K2039/5320130101 , A61K9/127 , A61K39/39558 , C07K16/28 , C07K2317/62220130101 , C07K2319/0320130101 , A61K35/17 , A61P35/00 , A61P37/04 , A61P43/00 , A61K39/001112 , A61K39/001124 , A61K39/00111 , A61K39/001113 , A61K39/001182 , A61K39/001188 , A61K39/001168 , A61K39/001195 , A61K2239/3820230501 , A61K39/464412 , C12N5/0636 , A61K39/001102 , A61K39/4631 , A61K2239/4820230501 , A61K2239/1720230501 , A61K39/464402 , A61K2239/3120230501 , A61K2239/2220230501 , A61K39/4611
摘要： The present invention generally embraces the treatment of diseases by targeting cells expressing an antigen on the cell surface. In particular the invention relates to a method for stimulating, priming and/or expanding in vivo T cells genetically modified to express a chimeric antigen receptor (CAR) targeted to an antigen, comprising contacting the T cells with the antigen or a variant thereof in vivo. In one embodiment, the antigen or variant thereof is provided by administering a nucleic acid encoding the antigen or variant thereof.
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3.发明公开FUSION PROTEINS COMPRISING MODIFIED ALPHA VIRUS SURFACE GLYCOPROTEINS AND TUMOR ASSOCIATED ANTIGEN AND METHODS THEREOF 审中-公开包含修饰的α病毒表面糖蛋白和肿瘤相关抗原的融合蛋白及其方法
公开(公告)号：EP3270958A2
公开(公告)日：2018-01-24
申请号：EP16765844.2
申请日：2016-03-18
申请人： Omnicyte
CPC分类号： A61K39/0011 , A61K39/001188 , A61K39/385 , A61K2039/6075 , A61P35/00 , C07K14/005 , C07K2319/00 , C12N2770/36134
摘要： The present disclosure relates to fusion proteins that comprise one or more modified alpha virus surface glycoproteins and one or more tumor specific antigens. Also disclosed are fusion proteins that comprise one or more modified alpha virus surface glycoproteins and one or more viral specific antigens. Also disclosed are fusion proteins that comprise one or more modified alpha virus surface glycoproteins. It also relates to methods to activate the immune system in cancer patients to infiltrate and kill tumor cells or cells infected with a latent virus. The present disclosure provides a platform technology that elicits a faster, broader and stronger immune response using the fusion proteins.
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公开(公告)号：EP3480208B1
公开(公告)日：2024-09-04
申请号：EP17819379.3
申请日：2017-07-01
CPC分类号： A61K39/39 , A61K9/107 , C07K7/08 , A61P31/04 , A61P31/10 , A01K2227/10520130101 , A01K2267/033720130101 , A61K39/001135 , A61K39/001188 , A61K2039/5320130101 , A61K2039/5556120130101 , A61K38/00
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公开(公告)号：EP4419549A1
公开(公告)日：2024-08-28
申请号：EP22883097.2
申请日：2022-10-21
发明人： HIRANO, Naoto , MURATA, Kenji , LY, Dalam , SAIJO, Hiroshi , MATSUNAGA, Yukiko
IPC分类号： C07K14/74 , A61K31/7088 , A61K38/17 , A61K38/46 , A61P35/00 , A61P37/02 , C12N15/10 , C12N15/12
CPC分类号： A61P35/00 , A61P37/02 , C07K14/70539 , A61K45/06 , A61K39/001184 , A61K39/001186 , A61K39/12 , A61K39/001188 , A61K39/001192 , C12N2740/1613420130101 , C12N2740/1623420130101
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公开(公告)号：EP3400069A1
公开(公告)日：2018-11-14
申请号：EP17736249.8
申请日：2017-01-04
发明人： GETTS, Daniel R.
CPC分类号： A61K9/5153 , A61K39/0008 , A61K39/001184 , A61K39/001186 , A61K39/001188 , A61K2039/55555 , A61K2039/55566 , A61K2039/572 , A61K2039/577 , A61K2039/70 , C07K14/4713 , C07K2319/00 , C07K2319/40 , C07K2319/50
摘要： The present invention provides compositions comprising biodegradable particles that encapsulate two or more epitopes linked together by one or more linkers that are susceptible to cleavage by specific proteases. The present invention further provides methods for inducing antigen-specific tolerance and protective immune responses and for the treatment inflammatory diseases, such as autoimmune diseases, allergies, cancers, or infectious diseases.
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