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公开(公告)号：EP3512557B1
公开(公告)日：2024-09-25
申请号：EP17771393.0
申请日：2017-09-14
IPC分类号： A61K31/704 , A61K31/136 , A61K31/44 , A61K45/06 , A61P35/00 , A61K39/00 , A61K39/395 , A61K31/7032 , A61K31/555 , A61K31/675
CPC分类号： A61K39/0011 , A61K39/39558 , A61K45/06 , A61K31/7032 , A61K31/704 , A61P35/00 , A61K2039/54520130101 , A61K2039/5551620130101 , A61K2039/5557220130101 , A61K39/3955 , C07K16/2818 , A61K2039/50520130101 , C07K2317/7320130101 , A61K31/136 , A61K31/44 , A61K31/555 , A61K31/675 , A61K39/001104 , A61K39/001129 , A61K39/001124 , A61K39/001106 , A61K39/001174 , A61K39/001135
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公开(公告)号：EP4357356A3
公开(公告)日：2024-07-31
申请号：EP23220228.3
申请日：2020-11-13
申请人： Enterome S.A.
CPC分类号： A61K39/001112 , A61K39/001113 , A61K39/001117 , A61K39/001124 , A61K39/001129 , A61P35/00 , C07K14/4748 , A61K2039/5556620130101 , A61K2039/5551620130101
摘要： The present invention relates to antigen-based immunotherapy, in particular cancer immunotherapy. In particular, the present invention provides antigenic peptides, which are distinct from, but have amino acid similarity to, especially share the same core sequence with epitopes of human tumor antigens. The present invention further provides immunogenic compounds, nanoparticles, cells and pharmaceutical compositions comprising such antigenic peptides and nucleic acids encoding such antigenic peptides.
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公开(公告)号：EP4357356A2
公开(公告)日：2024-04-24
申请号：EP23220228.3
申请日：2020-11-13
申请人： Enterome S.A.
IPC分类号： C07K14/47
CPC分类号： A61K39/001112 , A61K39/001113 , A61K39/001117 , A61K39/001124 , A61K39/001129 , A61P35/00 , C07K14/4748 , A61K2039/5556620130101 , A61K2039/5551620130101
摘要： The present invention relates to antigen-based immunotherapy, in particular cancer immunotherapy. In particular, the present invention provides antigenic peptides, which are distinct from, but have amino acid similarity to, especially share the same core sequence with epitopes of human tumor antigens. The present invention further provides immunogenic compounds, nanoparticles, cells and pharmaceutical compositions comprising such antigenic peptides and nucleic acids encoding such antigenic peptides.
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公开(公告)号：EP4273160A3
公开(公告)日：2024-04-24
申请号：EP23185472.0
申请日：2016-05-09
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： A61K39/00 , A61K35/17 , C07K14/725
CPC分类号： A61K39/0011 , C07K14/7051 , A61K2039/5320130101 , A61K9/127 , A61K39/39558 , C07K16/28 , C07K2317/62220130101 , C07K2319/0320130101 , A61K35/17 , A61P35/00 , A61P37/04 , A61P43/00 , A61K39/001112 , A61K39/001124 , A61K39/00111 , A61K39/001113 , A61K39/001182 , A61K39/001188 , A61K39/001168 , A61K39/001195 , A61K2239/3820230501 , A61K39/464412 , C12N5/0636 , A61K39/001102 , A61K39/4631 , A61K2239/4820230501 , A61K2239/1720230501 , A61K39/464402 , A61K2239/3120230501 , A61K2239/2220230501 , A61K39/4611
摘要： The present invention generally embraces the treatment of diseases by targeting cells expressing an antigen on the cell surface. In particular the invention relates to a method for stimulating, priming and/or expanding in vivo T cells genetically modified to express a chimeric antigen receptor (CAR) targeted to an antigen, comprising contacting the T cells with the antigen or a variant thereof in vivo. In one embodiment, the antigen or variant thereof is provided by administering a nucleic acid encoding the antigen or variant thereof.
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