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1.发明公开CLAUDIN-6-SPECIFIC IMMUNORECEPTORS AND T CELL EPITOPES 审中-公开CLAUDIN-6-SPEZIFISCHE IMMUNREZPTOREN UND T-ZELL-EPITOPE
公开(公告)号：EP3126381A1
公开(公告)日：2017-02-08
申请号：EP15712657.4
申请日：2015-03-30
申请人： Biontech Cell&Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , Ganymed Pharmaceuticals AG
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana , HOFF, Holger , VOSS, Ralf-Holger , BREITKREUZ, Andrea , HOBOHM, Kathleen , MROZ, Karolina, Anna
IPC分类号： C07K14/725 , C07K14/47 , A61P35/00 , A61K35/26
CPC分类号： C07K14/4748 , A61K35/17 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K2039/5156 , A61K2039/5158 , C07K14/7051 , C07K14/70521 , C07K14/70539 , C07K16/28 , C07K2317/56 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C07K2319/30 , G01N33/505 , G01N33/56972 , G01N33/574
摘要： The present invention provides Claudin-6-specific immunoreceptors (T cell receptors and artificial T cell receptors (chimeric antigen receptors; CARs)) and T cell epitopes which are useful for immunotherapy.
摘要翻译： 本发明提供了可用于免疫治疗的紧密连接蛋白-6特异性免疫受体（T细胞受体和人工T细胞受体（嵌合抗原受体; CAR））和T细胞表位。
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公开(公告)号：EP3514172B1
公开(公告)日：2020-03-11
申请号：EP19151238.3
申请日：2015-03-30
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , Ganymed Pharmaceuticals GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana , HOFF, Holger , VOSS, Ralf-Holger , BREITKREUZ, Andrea , HOBOHM, Kathleen , MROZ, Karolina Anna
IPC分类号： C07K14/725 , C07K14/47 , A61P35/00 , A61K35/26
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公开(公告)号：EP3514172A1
公开(公告)日：2019-07-24
申请号：EP19151238.3
申请日：2015-03-30
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , Ganymed Pharmaceuticals GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana , HOFF, Holger , VOSS, Ralf-Holger , BREITKREUZ, Andrea , HOBOHM, Kathleen , MROZ, Karolina Anna
IPC分类号： C07K14/725 , C07K14/47 , A61P35/00 , A61K35/26
摘要： The present invention provides Claudin-6-specific immunoreceptors (T cell receptors and artificial T cell receptors (chimeric antigen receptors; CARs)) and T cell epitopes which are useful for immunotherapy.
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公开(公告)号：EP4273160A2
公开(公告)日：2023-11-08
申请号：EP23185472.0
申请日：2016-05-09
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C07K14/725
摘要： The present invention generally embraces the treatment of diseases by targeting cells expressing an antigen on the cell surface. In particular the invention relates to a method for stimulating, priming and/or expanding in vivo T cells genetically modified to express a chimeric antigen receptor (CAR) targeted to an antigen, comprising contacting the T cells with the antigen or a variant thereof in vivo. In one embodiment, the antigen or variant thereof is provided by administering a nucleic acid encoding the antigen or variant thereof.
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公开(公告)号：EP4273160A3
公开(公告)日：2024-04-24
申请号：EP23185472.0
申请日：2016-05-09
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： A61K39/00 , A61K35/17 , C07K14/725
CPC分类号： A61K39/0011 , C07K14/7051 , A61K2039/5320130101 , A61K9/127 , A61K39/39558 , C07K16/28 , C07K2317/62220130101 , C07K2319/0320130101 , A61K35/17 , A61P35/00 , A61P37/04 , A61P43/00 , A61K39/001112 , A61K39/001124 , A61K39/00111 , A61K39/001113 , A61K39/001182 , A61K39/001188 , A61K39/001168 , A61K39/001195 , A61K2239/3820230501 , A61K39/464412 , C12N5/0636 , A61K39/001102 , A61K39/4631 , A61K2239/4820230501 , A61K2239/1720230501 , A61K39/464402 , A61K2239/3120230501 , A61K2239/2220230501 , A61K39/4611
摘要： The present invention generally embraces the treatment of diseases by targeting cells expressing an antigen on the cell surface. In particular the invention relates to a method for stimulating, priming and/or expanding in vivo T cells genetically modified to express a chimeric antigen receptor (CAR) targeted to an antigen, comprising contacting the T cells with the antigen or a variant thereof in vivo. In one embodiment, the antigen or variant thereof is provided by administering a nucleic acid encoding the antigen or variant thereof.
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公开(公告)号：EP3708579A1
公开(公告)日：2020-09-16
申请号：EP20160141.6
申请日：2015-03-30
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , Ganymed Pharmaceuticals GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , OEHM, Petra , OMOKOKO, Tana , HOFF, Holger , VOSS, Ralf-Holger , BREITKREUZ, Andrea , HOBOHM, Kathleen , MROZ, Karolina Anna
IPC分类号： C07K14/725 , C07K14/47 , A61P35/00 , A61K35/26
摘要： The present invention provides Claudin-6-specific immunoreceptors (T cell receptors and artificial T cell receptors (chimeric antigen receptors; CARs)) and T cell epitopes which are useful for immunotherapy.
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公开(公告)号：EP3126381B1
公开(公告)日：2019-01-16
申请号：EP15712657.4
申请日：2015-03-30
申请人： Biontech Cell&Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , Ganymed Pharmaceuticals GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana , HOFF, Holger , VOSS, Ralf-Holger , BREITKREUZ, Andrea , HOBOHM, Kathleen , MROZ, Karolina, Anna
IPC分类号： C07K14/725 , C07K14/47 , A61P35/00 , A61K35/26
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