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公开(公告)号：EP1237926B1
公开(公告)日：2009-06-03
申请号：EP00983939.0
申请日：2000-12-06
发明人： BUECHLER, Joe , VALKIRS, Gunars , GRAY, Jeff , LONBERG, Nils
CPC分类号： C07K16/18 , C07K16/244 , C07K2317/21 , C07K2317/55 , G01N33/543 , Y02A50/55 , Y02A50/58 , Y10S435/962 , Y10S435/973 , Y10S436/809
摘要： The invention provides in vitro methods of detection using human antibodies. The methods are particularly useful for analyzing human samples containing HAMA or heterophilic antibodies. A human antibody can bind to an analyte in such samples without binding to HAMA or heterophilic antibodies present in the samples. The methods can be effected using a sandwich format among others.
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2.发明授权production and use of transgenic non-human animals capable of producing heterologous antibodies 失效生产和Nützung非人transgentiere异源抗体的产生
公开(公告)号：EP0546073B1
公开(公告)日：1997-09-10
申请号：EP91916470.7
申请日：1991-08-28
发明人： LONBERG, Nils , KAY, Robert, M.
CPC分类号： C12N15/907 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/01 , A61K38/00 , C07K14/7051 , C07K16/00 , C07K16/2812 , C07K16/3007 , C07K16/4266 , C07K16/4291 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C12N5/163 , C12N15/00 , C12N15/85 , C12N15/8509 , C12N15/87 , C12N15/90 , C12N2830/008 , C12N2830/15 , C12N2830/36 , C12N2830/60 , C12N2840/44
摘要： The invention relates to transgenic non-human animals capable of producing heterologous antibodies, i.e., antibodies encoded by immunoglobulin heavy and light chain genes not normally found in the genome of that species of non-human animal. In one aspect of the invention, transgenes encoding unrearranged heterologous human immunoglobulin heavy and light chains are introduced into a non-human animal thereby forming a transgenic animal capable of producing antibodies encoded by human immunoglobulin genes. Such heterologous human antibodies are produced in B-cells which are thereafter immortalized, e.g., by fusing with an immortalizing cell line such as a myeloma or by manipulating such B-cells by other techniques to perpetuate a cell line capable of producing a monoclonal heterologous antibody. The invention also relates to heavy and light chain immunoglobulin transgenes for making such transgenic non-human animals as well as methods and vectors for disrupting endogenous immunoglobulin loci in the transgenic animal. The invention also includes methods to generate a synthetic immunoglobulin variable region gene segment repertoire used in transgene construction and methods to induce heterologous antibody production using animals containing heterologous rearranged or unrearranged heavy and light chain immunoglobulin transgenes.
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3.发明公开
公开(公告)号：EP0754225A1
公开(公告)日：1997-01-22
申请号：EP94916581.0
申请日：1994-04-25
发明人： LONBERG, Nils , KAY, Robert M.
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K38/00 , C07K16/00 , C07K16/2812 , C07K16/3007 , C07K16/4291 , C07K16/44 , C07K16/462 , C07K2317/24
摘要： The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.
摘要翻译： 本发明涉及能够产生异源抗体的转基因非人类动物以及用于产生以足够亲和力结合人抗原的人类序列抗体的方法。
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4.发明授权TRANSGENIC NON-HUMAN ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES 失效转基因非人动物能够产生异源ANTIKOERPER的
公开(公告)号：EP0854917B1
公开(公告)日：2010-05-05
申请号：EP96941938.1
申请日：1996-10-10
IPC分类号： C12N15/00 , A01K67/027 , C07K16/28 , C07K16/00 , C07K16/30
CPC分类号： C12N15/8509 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/0368 , A61K38/00 , C07K14/7051 , C07K16/00 , C07K16/2812 , C07K16/3007 , C07K16/4266 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/92 , C07K2319/00 , C12N5/163 , C12N15/00 , C12N15/113 , C12N15/85 , C12N15/87 , C12N15/90 , C12N15/907 , C12N2310/111 , C12N2800/206 , C12N2800/70 , C12N2830/30 , C12N2830/36 , C12N2830/85
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5.发明公开TRANSGENIC NON-HUMAN ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES 失效非人类为了生产异源抗体CAPABLE转基因动物。
公开(公告)号：EP0546073A1
公开(公告)日：1993-06-16
申请号：EP91916470.0
申请日：1991-08-28
发明人： LONBERG, Nils , KAY, Robert, M.
CPC分类号： C12N15/907 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/01 , A61K38/00 , C07K14/7051 , C07K16/00 , C07K16/2812 , C07K16/3007 , C07K16/4266 , C07K16/4291 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C12N5/163 , C12N15/00 , C12N15/85 , C12N15/8509 , C12N15/87 , C12N15/90 , C12N2830/008 , C12N2830/15 , C12N2830/36 , C12N2830/60 , C12N2840/44
摘要： L'invention se rapporte à des animaux non humains transgéniques, qui sont capables de produire des anticorps hétérologues, c'est-à-dire des anticorps pour lesquels codent des gènes à chaînes lourdes et légères d'immunoglobuline qu'on ne trouve normalement pas dans le génome de cette espèce d'animal non humain. Dans un aspect de la présente invention, des transgènes codant pour des chaînes lourdes et légères d'immunoglobuline humaine hétérologue non remaniée sont introduits dans un animal non humain, de façon à obtenir un animal transgénique capable de produire des anticorps pour lesquels codent des gènes d'immunoglobuline humains. Ces anticorps hétérologues humains sont produits dans des lymphocytes B qu'on immortalise ensuite, par exemple en les faisant fusionner avec une lignée cellulaire d'immortalisation, telle qu'un myélome, ou en manipulant ces lymphocytes B au moyen d'autres techniques en vue de perpétuer une lignée cellulaire capable de produire un anticorps hétérologue monoclonal. La présente invention se rapporte également à des transgènes d'immunoglobuline à chaînes lourdes et légères permettant de produire des animaux non humains transgéniques, ainsi qu'à des procédés et à des vecteurs permettant de dissocier les locus d'immunoglobuline endogène dans l'animal transgénique. L'invention se rapporte en outre à des procédés permettant de générer un répertoire de segments de gènes de la région variable de l'immunoglobuline synthétique, destiné à être utilisé dans la construction de transgènes, ainsi qu'à des procédés permettant d'induire une production d'anticorps hétérologues grâce à l'utilisation d'animaux contenant des transgènes d'immunoglobuline à chaînes lourdes et légères remaniée ou non remaniée hétérologue.
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公开(公告)号：EP1237926A1
公开(公告)日：2002-09-11
申请号：EP00983939.0
申请日：2000-12-06
发明人： BUECHLER, Joe , VALKIRS, Gunars , GRAY, Jeff , LONBERG, Nils
CPC分类号： C07K16/18 , C07K16/244 , C07K2317/21 , C07K2317/55 , G01N33/543 , Y02A50/55 , Y02A50/58 , Y10S435/962 , Y10S435/973 , Y10S436/809
摘要： The invention provides in vitro methods of detection using human antibodies. The methods are particularly useful for analyzing human samples containing HAMA or heterophilic antibodies. A human antibody can bind to an analyte in such samples without binding to HAMA or heterophilic antibodies present in the samples. The methods can be effected using a sandwich format among others.
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7.发明公开TRANSGENIC NON-HUMAN ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES 失效转基因非人动物能够产生异源ANTIKOERPER的
公开(公告)号：EP0854917A1
公开(公告)日：1998-07-29
申请号：EP96941938.0
申请日：1996-10-10
发明人： LONBERG, Nils , KAY, Robert, M.
CPC分类号： C12N15/8509 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/0368 , A61K38/00 , C07K14/7051 , C07K16/00 , C07K16/2812 , C07K16/3007 , C07K16/4266 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/92 , C07K2319/00 , C12N5/163 , C12N15/00 , C12N15/113 , C12N15/85 , C12N15/87 , C12N15/90 , C12N15/907 , C12N2310/111 , C12N2800/206 , C12N2800/70 , C12N2830/30 , C12N2830/36 , C12N2830/85
摘要： The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.
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