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公开(公告)号：EP2427216B1
公开(公告)日：2019-02-20
申请号：EP10718581.1
申请日：2010-05-05
申请人： Biotest AG , ImmunoGen, Inc.
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2.发明公开METHOD OF DECREASING CYTOTOXIC SIDE-EFFECTS AND IMPROVING EFFICACY OF IMMUNOCONJUGATES 审中-公开法降低细胞毒副作用及免疫偶联物的有效性
公开(公告)号：EP2238169A1
公开(公告)日：2010-10-13
申请号：EP08864283.0
申请日：2008-12-23
申请人： Biotest AG , Immunogen, Inc.
发明人： SCHULZ, Gregor , OSTERROTH, Frank , AIGNER, Silke , UHEREK, Christoph , BRUECHER, Christoph , ZENG, Steffen , DAELKEN, Benjamin , RUEHLE, Markus , KRAUS, Elmar
CPC分类号： C07K16/2896 , A61K39/39558 , A61K47/48561 , A61K47/48569 , A61K47/48723 , A61K47/6849 , A61K47/6851 , A61K47/6891 , A61K2039/505 , A61K2300/00 , B82Y5/00 , C07K2317/24 , C07K2317/34
摘要： Disclosed are methods, compositions and kits for improving targeting, in particular tumor targeting, of immunoconjugates. The method and composition relies on the sequestration of non-target cells that also express the antigen the immunoconjugate targets. Sequestration of those non-target cells in a variety of ways is disclosed. The methods, compositions and kits allow appropriate sequestration of non-target cells while maintaining a high degree of effectiveness of the immunoconjugates against target cells.
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3.发明授权IMMUNOCONJUGATES TARGETING CD138 AND USES THEREOF 有权AUF CD138 ZIELENDE IMMUNKONJUGATE UND ANWENDUNGEN DAVON
公开(公告)号：EP2242772B1
公开(公告)日：2014-11-26
申请号：EP08865838.0
申请日：2008-12-23
申请人： Biotest AG , Immunogen, Inc.
发明人： KRAUS, Elmar , BRUECHER, Christoph , DAELKEN, Benjamin , ZENG, Steffen , OSTERROTH, Frank , UHEREK, Christoph , AIGNER, Silke , GERMER, Matthias , SCHULZ, Gregor , HAEDER, Thomas
IPC分类号： C07K16/28 , C07K16/30 , A61P35/00 , A61K47/48 , A61K39/395
CPC分类号： C07K16/2896 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K47/6877 , C07K2317/24 , C07K2317/565 , C07K2317/92
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公开(公告)号：EP2427216A2
公开(公告)日：2012-03-14
申请号：EP10718581.1
申请日：2010-05-05
申请人： Biotest AG , ImmunoGen, Inc.
发明人： OSTERROTH, Frank , UHEREK, Christoph , BRUECHER, Christoph , DAELKEN, Benjamin , ENGLING, André , HAEDER, Thomas , WARTENBERG-DEMAND, Andrea , NIEMANN, Gabriele , ZUBER, Chantal , CZELOTH, Niklas , AIGNER, Silke , ZENG, Steffen , SCHULZ, Gregor
CPC分类号： A61K47/6425 , A61K47/66 , A61K47/6851 , B82Y5/00
摘要： Disclosed are methods and treatment regimes that include the administration of immunconjugates targeting CD138 to combat diseases. The immunoconjugate is either used as the sole active ingredient, as part of a treatment regime or as part of an anticancer combination.
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5.发明授权METHODS AND AGENTS FOR IMPROVING TARGETING OF CD138 EXPRESSING TUMOR CELLS 有权方式和途径改进ABZIELUNG ON CD138表达的肿瘤细胞
公开(公告)号：EP2240516B1
公开(公告)日：2015-07-08
申请号：EP08865592.3
申请日：2008-12-23
发明人： DAELKEN, Benjamin , UHEREK, Christoph , ANDERSON, Kenneth , HIDESHIMA, Teru , BRUECHER, Christoph , OSTERROTH, Frank , AIGNER, Silke , GERMER, Matthias
IPC分类号： C07K16/28 , C07K16/30 , A61P35/00 , A61K47/48 , A61K39/395
CPC分类号： A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K2039/505 , C07K16/2896 , C07K2317/34 , C07K2317/73 , C07K2317/92
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公开(公告)号：EP2242772A1
公开(公告)日：2010-10-27
申请号：EP08865838.0
申请日：2008-12-23
申请人： Biotest AG , Immunogen, Inc.
发明人： KRAUS, Elmar , BRUECHER, Christoph , DAELKEN, Benjamin , ZENG, Steffen , OSTERROTH, Frank , UHEREK, Christoph , AIGNER, Silke , GERMER, Matthias
IPC分类号： C07K16/28 , C07K16/30 , A61P35/00 , A61K47/48 , A61K39/395
CPC分类号： C07K16/2896 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K47/6877 , C07K2317/24 , C07K2317/565 , C07K2317/92
摘要： Disclosed are immunoconjugates having in particular specificity for CD138 expressed on target cells and which display homogenous targeting. The immunoconjugates may be sterially hindered and/or contain a cleavable linker.
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公开(公告)号：EP2238168A1
公开(公告)日：2010-10-13
申请号：EP08863602.2
申请日：2008-12-23
申请人： Biotest AG
发明人： KRAUS, Elmar , BRUECHER, Christoph , DAELKEN, Benjamin , GERMER, Matthias , ZENG, Steffen , OSTERROTH, Frank , UHEREK, Christoph , AIGNER, Silke
CPC分类号： C07K16/28 , A61K47/6803 , A61K47/6849 , A61K2039/505 , A61K2039/545 , C07K16/2896 , C07K16/30 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Disclosed is a human murine chimeric antibody which substantially retains the antigen binding region of its murine counterpart and displays improved binding affinities to the antigen and/or more homogenous binding to target cells.
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公开(公告)号：EP2265643B1
公开(公告)日：2016-10-19
申请号：EP09727585.3
申请日：2009-03-10
申请人： Biotest AG
发明人： OSTERROTH, Frank , AIGNER, Silke , GERMER, Matthias , UHEREK, Christoph , KRAUS, Elmar , WARTENBERG-DEMAND, Andrea , WOLF, Daniele , KAISER, Sibylle , LINDNER, Juergen , BRUECHER, Christoph , DAELKEN, Benjamin , SCHULZ, Gregor
IPC分类号： C07K16/28 , A61K39/395 , A61P37/06 , C07K16/46
CPC分类号： C07K16/2812 , A61K2039/505 , A61K2039/545 , C07K2317/24 , C07K2317/56 , C07K2317/92
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公开(公告)号：EP2262838B1
公开(公告)日：2016-04-13
申请号：EP09729626.3
申请日：2009-03-10
申请人： Biotest AG
发明人： GERMER, Matthias , OSTERROTH, Frank , AIGNER, Silke , UHEREK, Christoph , KRAUS, Elmar , WARTENBERG-DEMAND, Andrea , WOLF, Daniele , KAISER, Sibylle , LINDNER, Juergen , BRUECHER, Christoph , DAELKEN, Benjamin , SCHULZ, Gregor
IPC分类号： C07K16/28 , A61K39/395 , A61P37/06 , C07K16/46
CPC分类号： C07K16/2812 , A61K2039/505 , A61K2039/545 , C07K2317/24 , C07K2317/56 , C07K2317/732 , C07K2317/92
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公开(公告)号：EP2262838A1
公开(公告)日：2010-12-22
申请号：EP09729626.3
申请日：2009-03-10
申请人： Biotest AG
发明人： GERMER, Matthias , OSTERROTH, Frank , AIGNER, Silke , UHEREK, Christoph , KRAUS, Elmar , WARTENBERG-DEMAND, Andrea , WOLF, Daniele , KAISER, Sibylle , LINDNER, Juergen , BRUECHER, Christoph , DAELKEN, Benjamin
IPC分类号： C07K16/28 , A61K39/395 , A61P37/06 , C07K16/46
CPC分类号： C07K16/2812 , A61K2039/505 , A61K2039/545 , C07K2317/24 , C07K2317/56 , C07K2317/732 , C07K2317/92
摘要： The provision of a pharmaceutical composition for treating an autoimmune disease comprising a pharmaceutically acceptable carrier and an agent capable of activating CD4+CD25+ regulatory T cells, wherein the composition is to be administered to a subject in a dose of the agent from 10 mg to 200 mg.
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