公开(公告)号：EP4317411A1

公开(公告)日：2024-02-07

申请号：EP22774314.3

申请日：2022-03-24

申请人： Bloomage Biotechnology Corporation Limited

发明人： LU, Zhen ,  WEI, Yujie ,  SUN, Yuanjun ,  DU, Ranran ,  ZHAO, Yan ,  GUO, Xueping

IPC分类号： C12N1/20 ,  C12P21/00 ,  C12P19/04 ,  C12P13/04 ,  A61K8/99 ,  A61P17/00 ,  A61P31/10 ,  A61P37/04 ,  A61Q17/00 ,  A61Q19/00 ,  C12R1/225

摘要： Disclosed are a Lactobacillus rhamnosus strain having accession number CCTCC NO: M 2021185, a ferment lysate prepared thereby for regulating skin microecology, and a preparation method for the ferment lysate. The ferment lysate comprises the following components in mass percentages of same in the ferment lysate: 0.2-1% of proteins, 0.3-0.8% of polysaccharides, and 0.2-1% of amino acids. The ferment lysate obtained by using the above bacterial strain for fermentation can strongly inhibit the reproduction and growth of pathogenic bacteria, has a promotion effect on some of probiotics, has a strong inhibition effect on pathogenic hyphae of Candida albicans, can not only generate antimicrobial peptides during fermentation, but also increase the expression level of antimicrobial peptides in skin cells at the genetic level and the protein level, thereby improving skin immunity.