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1.发明公开
公开(公告)号：EP4303300A1
公开(公告)日：2024-01-10
申请号：EP21928623.4
申请日：2021-03-23
发明人： WANG, Hao , ZHANG, Tianmeng , XU, Rongrong , ZHANG, Youheng , GUO, Xueping , HAO, Jingkun
摘要： Provided is a gene for efficiently expressing hyaluronic acid hydrolase. A nucleotide sequence of the gene is represented by SEQ ID NO: 4. By truncating a segment of a signal peptide sequence at the N-terminus of a full-length hyaluronic acid hydrolase gene, the Pichia pastoris engineering strain of high level expression genetic engineering hyaluronic acid hydrolase is constructed. The enzyme activity of the hyaluronic acid hydrolase in a fermentation broth obtained by high-density fermentation using the constructed Pichia pastoris engineering strain is up to 4.7×10 5 U/mL.
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公开(公告)号：EP4050096A1
公开(公告)日：2022-08-31
申请号：EP19950145.3
申请日：2019-12-17
发明人： KANG, Zhen , CHEN, Jian , HU, Litao , DU, Guocheng , WANG, Yang , LI, Jianghua , LI, Jialian , ZHANG, Tianmeng
摘要： Disclosed is a high-efficiency synthesis and high-purity hyaluronic acid, and a recombinant corynebacterium glutamicum for an oligosaccharide thereof, relating to the technical field of bio-engineering. The yield of hyaluronic acid produced by the constructed recombinant corynebacterium glutamicum reaches 40 g/L, and the purity of the crude product reaches 95%. By means of a hyaluronic acid hydrolase from an external source and optimizing fermentation conditions, hyaluronic acid oligosaccharide of a specific molecular weight can be obtained, and further increasing of hyaluronic acid yield can be achieved, causing the yield to reach 72 g/L.
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公开(公告)号：EP4379133A1
公开(公告)日：2024-06-05
申请号：EP21951637.4
申请日：2021-11-16
发明人： LIU, Zhe , YANG, Juan
摘要： A composition containing sodium hyaluronate and an application thereof. The composition has water activity of 0.330 to 0.930, and sodium hyaluronate makes up 0.01 to 5% of the composition in terms of the mass percentage. The composition comprises sodium hyaluronate and a water activity regulator. By means of controlling the water activity, the composition may reduce the risk of corrosion of cast iron devices, ensure the coating uniformity of paper products, improve the softness of the paper products, and give the paper products certain emollient properties.
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4.发明公开
公开(公告)号：EP4317411A1
公开(公告)日：2024-02-07
申请号：EP22774314.3
申请日：2022-03-24
发明人： LU, Zhen , WEI, Yujie , SUN, Yuanjun , DU, Ranran , ZHAO, Yan , GUO, Xueping
IPC分类号： C12N1/20 , C12P21/00 , C12P19/04 , C12P13/04 , A61K8/99 , A61P17/00 , A61P31/10 , A61P37/04 , A61Q17/00 , A61Q19/00 , C12R1/225
摘要： Disclosed are a Lactobacillus rhamnosus strain having accession number CCTCC NO: M 2021185, a ferment lysate prepared thereby for regulating skin microecology, and a preparation method for the ferment lysate. The ferment lysate comprises the following components in mass percentages of same in the ferment lysate: 0.2-1% of proteins, 0.3-0.8% of polysaccharides, and 0.2-1% of amino acids. The ferment lysate obtained by using the above bacterial strain for fermentation can strongly inhibit the reproduction and growth of pathogenic bacteria, has a promotion effect on some of probiotics, has a strong inhibition effect on pathogenic hyphae of Candida albicans, can not only generate antimicrobial peptides during fermentation, but also increase the expression level of antimicrobial peptides in skin cells at the genetic level and the protein level, thereby improving skin immunity.
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公开(公告)号：EP4245304A1
公开(公告)日：2023-09-20
申请号：EP21891087.5
申请日：2021-11-09
发明人： WEI, Yujie , LU, Zhen , CHEN, Qingping , LI, Jie , SUN, Yuanjun , XIE, Wenjuan , DU, Ranran , GUO, Wenyi , GUO, Xueping
IPC分类号： A61K31/4172 , A61K47/36 , A61K47/26 , A61P39/06 , A61P17/16
摘要： The present application provides a use of a hyaluronic acid or a salt thereof and/or trehalose in stabilizing ergothioneine, an additive for stabilizing ergothioneine, the additive containing the hyaluronic acid or the salt thereof and/or trehalose, and a composition, the composition containing ergothioneine, the hyaluronic acid or the salt thereof, and trehalose. Compared with other auxiliary materials, the hyaluronic acid or the salt thereof and trehalose provided by the present invention can obviously mitigate the damageof a high temperature to ergothioneine, thereby increasing the yield of an ergothioneine powder product. The composition obtained by the present invention has good antioxidant and anti-apoptotic effects. Moreover, the inhibitory and scavenging effects of a composition obtained by compounding the hyaluronic acid or the salt thereof and trehalose to be used as an auxiliary material on intracellular reactive oxygen speciesare obviously better than those of a composition obtained by using a single hyaluronic acid or a salt thereofor trehalose as an auxiliary material.
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公开(公告)号：EP4427754A1
公开(公告)日：2024-09-11
申请号：EP22889399.6
申请日：2022-11-04
发明人： SHI, Yanli , LIU, Cuihua , GUO, Xueping , FAN, Shengnan , FENG, Ning , ZHAO, Lianzhen
IPC分类号： A61K31/728 , A61K47/36 , A61P37/04 , A61P29/00 , A23L33/125 , A61P1/00
CPC分类号： Y02A50/30 , A61P29/00 , A61P1/00 , A61K47/36 , A61P37/04 , A61K31/728 , A23L33/125
摘要： A composition containing hyaluronic acids or salts thereof for improving the immunity of an organism and protecting the health of the gastrointestinal tract, and the use thereof. The composition containing hyaluronic acids or salts thereof contains hyaluronic acids of three molecular weights or salts thereof. The composition achieves the effects of enhancing immunity, alleviating intestinal inflammation, promoting intestinal peristalsis and regulating intestinal flora by means of a synergistic effect; can be added to food and health-care food as a functional ingredient; and can also be used as an excipient in combination with a drug.
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公开(公告)号：EP4403079A1
公开(公告)日：2024-07-24
申请号：EP21957296.3
申请日：2021-11-16
发明人： LIU, Zhe , YANG, Juan
IPC分类号： A47K10/16
摘要： Disclosed are a tissue containing sodium hyaluronate and a preparation method therefor. The average fiber length of the tissue is 0.7-1.4 mm; the water content in the tissue is 8-20 wt%; the water activity A of the tissue satisfies the following formula: A
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公开(公告)号：EP3904499A1
公开(公告)日：2021-11-03
申请号：EP19902062.9
申请日：2019-11-15
申请人： Bloomage Biotechnology Corporation Limited , Shandong Bloomage Hyinc Biopharm Corporation Limited
发明人： WEI, Yujie , LU, Zhen , JIA, Yuqian , SUN, Yuanjun , CHEN, Wenwen , SHI, Yanli , LUAN, Yihong , GUO, Xueping
摘要： The present invention belongs to the field of microbial technology, and specifically relates to a strain of Hericium erinaceus HT-3, with a deposit number of CCTCC No: M 2018567. The present invention also relates to a screening method for Hericium erinaceus HT-3. The screening method comprises the steps of purifying the strain of Hericium erinaceus from a tissue block, fermenting and culturing the strain, soak extracting ergothioneine from the mycelium cells in the fermentation broth, detecting the ergothioine content in the fermentation broth. The Hericium erinaceus strain screened according to the present invention has high ergothioneine yield, and the screening method is simple in process, easy to be operated, and low in production cost.
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