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公开(公告)号：EP3298032A1
公开(公告)日：2018-03-28
申请号：EP16797158.9
申请日：2016-05-17
发明人： MORGAN, Richard , SIKORSKI, Robert , WONG, Brian , MASTELLER, Emma , BORGES, Luis , LIU, Cheng , XU, Yiyang
IPC分类号： C07K14/705 , C07K16/28 , C07K16/30 , C07K14/735 , A61K39/00
CPC分类号： A61K39/0011 , A61K2039/505 , A61P35/02 , C07K14/7051 , C07K16/2803 , C07K16/30 , C07K2317/622 , C07K2317/73 , C07K2319/03 , C07K2319/74
摘要： The invention provides improved compositions for adoptive cell therapies for cancers that express ROR1.
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公开(公告)号：EP3237447B1
公开(公告)日：2020-12-02
申请号：EP15823889.9
申请日：2015-12-21
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公开(公告)号：EP3212670A1
公开(公告)日：2017-09-06
申请号：EP15798264.6
申请日：2015-10-28
发明人： WONG, Brian , HAMBLETON, Julie , SIKORSKI, Robert , MASTELLER, Emma , HESTIR, Kevin , BELLOVIN, David , LEWIS, Katherine E.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2866 , A61K2039/505 , A61K2039/507 , A61K2039/54 , A61K2039/545 , C07K16/2803 , C07K16/2818 , C07K16/3046 , C07K16/3069 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
摘要翻译： 提供了用结合集落刺激因子1受体（CSF1R）与PD-1 / PD-L1抑制剂组合的抗体治疗癌症的方法。
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4.发明公开
公开(公告)号：EP3681535A1
公开(公告)日：2020-07-22
申请号：EP18779538.0
申请日：2018-09-12
发明人： LEWIS, Katherine E. , PERNA, Serena , CARLETON, Michael , XU, Ke , PHILLIPS, Penny , PANDYA, Dimple , WONG, Brian , HAMBLETON, Julie , SIKORSKI, Robert , MASTELLER, Emma , HESTIR, Kevin , BELLOVIN, David , POWERS, Janine , LEE, Ernestine
IPC分类号： A61K39/395 , A61K45/06 , C07K16/28 , A61K39/00
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公开(公告)号：EP3237447A1
公开(公告)日：2017-11-01
申请号：EP15823889.9
申请日：2015-12-21
CPC分类号： C07K16/2866 , A61K2039/505 , A61K2039/545 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Methods of treating pigmented villonodular synovitis (PVNS) with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided.
摘要翻译： 提供了用结合集落刺激因子1受体（CSF1R）的抗体治疗色素绒毛结节性滑膜炎（PVNS）的方法。
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公开(公告)号：EP3835323A1
公开(公告)日：2021-06-16
申请号：EP20207287.2
申请日：2015-10-28
发明人： WONG, Brian , HAMBLETON, Julie , SIKORSKI, Robert , MASTELLER, Emma , HESTIR, Kevin , BELLOVIN, David , LEWIS, Katherine E.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
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7.发明公开
公开(公告)号：EP3380523A1
公开(公告)日：2018-10-03
申请号：EP16816789.8
申请日：2016-11-22
发明人： PIERCE, Kristen , POWERS, Janine , PALENCIA, Servando , SIKORSKI, Robert , GHODDUSI, Majid , KRISHNAN, Kartik
IPC分类号： C07K16/28 , G01N33/574
CPC分类号： C07K16/2863 , A61K2039/505 , A61K2039/507 , A61K2039/55 , C07K16/2818 , C07K16/2896 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3069 , C07K16/3084 , C07K2317/34 , C07K2317/41 , G01N33/5091 , G01N33/57407 , G01N33/57446 , G01N33/57492 , G01N2333/71 , G01N2800/52
摘要： Provided herein are uses of fibroblast growth factor receptor 2 (FGFR2) inhibitors in cancer treatment, in some cases in combination with immune stimulating agents, such as inhibitors of PD-1 or PD-L1. In some embodiments, FGFR2 inhibitors may comprise FGFR2 antibodies or FGFR2 extracellular domain (ECD) polypeptides, or FGFR2 ECD fusion molecules comprising an FGFR2 ECD and a fusion partner. In some embodiments, PD-1/PD-L1 inhibitors may comprise anti-PD-1 antibodies such as antibodies that bind to PD-1 or to PD-L1 and inhibit interactions between these proteins, as well as PD-1 fusion proteins or polypeptides.
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8.发明公开METHODS OF TREATING CONDITIONS WITH ANTIBODIES THAT BIND COLONY STIMULATING FACTOR 1 RECEPTOR (CSF1R) 审中-公开METHOD FOR病杂志有用于绑集落刺激因子-1受体抗体治疗（CSF1R）
公开(公告)号：EP3157957A1
公开(公告)日：2017-04-26
申请号：EP15739052.7
申请日：2015-06-18
CPC分类号： C07K16/2866 , A61K2039/505 , A61K2039/545 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided. Such methods include, but are not limited to, methods of treating rheumatoid arthritis.
摘要翻译： 用抗体治疗疾病的方法做了结合细胞集落刺激因子1受体（CSF1R）被提供。 搜索方法包括，但不限于，治疗风湿性关节炎的方法。
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