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公开(公告)号：EP3298032A1
公开(公告)日：2018-03-28
申请号：EP16797158.9
申请日：2016-05-17
发明人： MORGAN, Richard , SIKORSKI, Robert , WONG, Brian , MASTELLER, Emma , BORGES, Luis , LIU, Cheng , XU, Yiyang
IPC分类号： C07K14/705 , C07K16/28 , C07K16/30 , C07K14/735 , A61K39/00
CPC分类号： A61K39/0011 , A61K2039/505 , A61P35/02 , C07K14/7051 , C07K16/2803 , C07K16/30 , C07K2317/622 , C07K2317/73 , C07K2319/03 , C07K2319/74
摘要： The invention provides improved compositions for adoptive cell therapies for cancers that express ROR1.
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公开(公告)号：EP3297671A2
公开(公告)日：2018-03-28
申请号：EP16797161.3
申请日：2016-05-17
发明人： WONG, Brian , MASTELLER, Emma , LIU, Cheng , XU, Yiyang , LIU, Hong , YAN, Su , XIANG, Jingyi , WANG, Pei
IPC分类号： A61K39/395 , C07K16/28 , C12N1/15 , C12N1/21 , G01N33/574
CPC分类号： C07K16/2803 , A61K38/05 , A61K47/6817 , A61K47/6851 , A61K47/6881 , A61K51/1027 , A61K51/1042 , A61K51/1096 , A61K2039/505 , A61P35/00 , A61P35/02 , C07K16/005 , C07K16/2809 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00 , G01N33/57492 , G01N2333/912
摘要： The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof, for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.
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公开(公告)号：EP3365364A1
公开(公告)日：2018-08-29
申请号：EP16858388.8
申请日：2016-10-21
发明人： LU, Jingwei , YANG, Zhiyuan , LIU, Cheng , LIU, Hong , XU, Yiyang , YAN, Su , CHAN, Vivien Wai-fan , HORAN, Lucas
IPC分类号： C07K14/725 , A61K38/17 , A61K35/17 , C12N15/62 , C12N15/63
CPC分类号： A61K39/39558 , A61K35/17 , A61K38/00 , A61K2039/505 , C07K14/7051 , C07K16/2809 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/03 , C07K2319/33 , C07K2319/74 , C12N15/62
摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
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公开(公告)号：EP3325517A2
公开(公告)日：2018-05-30
申请号：EP16828666.4
申请日：2016-07-22
发明人： LIU, Hong , XIANG, Jingyi , XU, Yiyang , CHAN, Vivien, Wai-Fan
IPC分类号： C07K19/00 , C07K16/18 , A61K39/395
CPC分类号： C07K16/2833 , C07K16/3069 , C07K2317/21 , C07K2317/32
摘要： The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising a PSA peptide and an MHC class I protein. Also provided are methods of making and using these constructs.
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公开(公告)号：EP4004030A1
公开(公告)日：2022-06-01
申请号：EP20843370.6
申请日：2020-07-24
发明人： YUN, Hongruo , CUI, Jun , ZHANG, Pengbo , XU, Yiyang , HORAN, Lucas , XU, Shaohua , XIONG, Guangyan , LI, Shan , XU, Yixiang , LIU, Hong
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公开(公告)号：EP3774919A1
公开(公告)日：2021-02-17
申请号：EP19777866.5
申请日：2019-03-29
发明人： YUN, Hongruo , LIU, Lianxing , GE, Xiaomei , XU, Shaohua , LIU, Hong , MORALES, Javier , CUI, Jun , ZHANG, Pengbo , XU, Yiyang , LI, Shan , XU, Yixiang , XIONG, Guangyan
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7.发明公开
公开(公告)号：EP3615046A1
公开(公告)日：2020-03-04
申请号：EP18791852.9
申请日：2018-04-24
发明人： LIU, Hong , ZHANG, Pengbo , HORAN, Lucas , XU, Yiyang , STALEY, Binnaz K. , LIU, Lianxing , YUN, Hongruo
IPC分类号： A61K35/17 , A61P35/00 , C07K14/725 , C07K16/30 , C07K19/00 , C12N5/0783
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公开(公告)号：EP3615567A1
公开(公告)日：2020-03-04
申请号：EP18789935.6
申请日：2018-04-24
发明人： HORAN, Lucas , XU, Yiyang , YANG, Zhiyuan , LIU, Hong , MORALES, Javier , LIU, Lianxing
IPC分类号： C07K14/725 , A61K35/17 , A61P35/00 , C07K16/30 , C07K19/00 , C12N5/0783
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公开(公告)号：EP3297673A2
公开(公告)日：2018-03-28
申请号：EP16800529.6
申请日：2016-05-20
发明人： SCHEINBERG, David, A. , DAO, Tao , LIU, Cheng , LIU, Hong , XU, Yiyang , YAN, Su
IPC分类号： A61K39/395 , C07K16/28 , C07K16/18 , C07K16/30
CPC分类号： C07K16/28 , A61K39/0011 , A61K47/6849 , A61K2039/505 , A61K2039/5156 , A61K2039/5158 , C07K14/00 , C07K16/2809 , C07K16/2833 , C07K16/30 , C07K16/3053 , C07K2317/21 , C07K2317/31 , C07K2317/32 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2319/03 , C07K2319/33 , C07K2319/74 , G01N33/57492 , G01N2333/705
摘要： The presently disclosed subject matter provides antigen-binding proteins that specifically bind to Preferentially expressed antigen of melanoma (PRAME), including humanized, chimeric and fully human antibodies against PRAME, antibody fragments (e.g., scFv, Fab and F(ab)2), chimeric antigen receptors (CARs), fusion proteins, and conjugates thereof. The antigen-binding proteins and antibodies bind to a PRAME peptide/HLA class I molecule complex. Such antibodies, fragments, fusion proteins and conjugates thereof are useful for the treatment of PRAME associated diseases, including for example, breast cancer, ovarian cancer, melanoma, lung cancer, gastrointestinal cancer, brain tumor, head and neck cancer, renal cancer, myeloma, neuroblastoma, mantle cell lymphoma, chronic myelocytic leukemia, multiple myeloma, acute lymphoblastic leukemia (ALL), acute myeloid/myelogenous leukemia (AML), Non-Hodgkin lymphoma (NHL), and Chronic lymphocytic leukemia (CLL). The antibodies or antigen binding proteins may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels.
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10.发明公开
公开(公告)号：EP4003373A1
公开(公告)日：2022-06-01
申请号：EP20843894.5
申请日：2020-07-24
发明人： YUN, Hongruo , CUI, Jun , ZHANG, Pengbo , XU, Yiyang , HORAN, Lucas , XU, Shaohua , XIONG, Guangyan , LI, Shan , XU, Yixiang , HELLER, Bradley Austin , ZHANG, Hongbing , LIU, Hong
IPC分类号： A61K35/17 , C07K14/705 , A61P35/00
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