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公开(公告)号:EP3768726A1
公开(公告)日:2021-01-27
申请号:EP19772548.4
申请日:2019-03-15
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公开(公告)号:EP3164195A1
公开(公告)日:2017-05-10
申请号:EP15814655.5
申请日:2015-07-03
发明人: HEFFERNAN, Timothy , TONIATTI, Carlo , KOVACS, Jeffrey , GIULIANI, Virginia , SPENCER, Nakia , DI FRANCESCO, Maria Emilia , BRISTOW, Christopher A.
IPC分类号: A61P39/06
CPC分类号: A61K31/501 , A61K31/433 , A61K31/4439
摘要: Disclosed herein are methods of treating a subject having an altered NRF2/KEAP1 pathway, and compounds and compositions useful in such treatment. Also disclosed herein are methods of evaluating whether to administer a compound that inhibits glutathione production or a glutaminase inhibitor to a subject.
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公开(公告)号:EP3694545A1
公开(公告)日:2020-08-19
申请号:EP18866472.6
申请日:2018-10-10
发明人: CURRAN, Michael, A. , TONIATTI, Carlo , JAISWAL, Ashvin, R. , ZHA, Dongxing , VOO, Kui , PRINZ, Bianka , BOLAND, Nadthakam
IPC分类号: A61K39/00 , A61K39/395 , C07K16/28
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公开(公告)号:EP3768723A1
公开(公告)日:2021-01-27
申请号:EP19771183.1
申请日:2019-03-14
发明人: CURRAN, Michael, A. , JAISWAL, Ashvin, R. , ZHA, Dongxing , TONIATTI, Carlo , PRINZ, Bianka , BOLAND, Nadthakarn , KRAULAND, Eric
IPC分类号: C07K16/28
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公开(公告)号:EP3768298A1
公开(公告)日:2021-01-27
申请号:EP19771524.6
申请日:2019-03-15
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