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公开(公告)号：EP3316887A1
公开(公告)日：2018-05-09
申请号：EP16818780.5
申请日：2016-06-30
发明人： LEWIS, Richard, Thomas , JONES, Philip , PETROCCHI, Alessia , REYNA, Naphtali , HAMILTON, Matthew , SOTH, Michael, J. , HEFFERNAN, Timothy , HAN, Michelle , BURKE, Jason, P.
IPC分类号： A61K31/501 , C07D417/14 , C07D207/00
摘要： Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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公开(公告)号：EP3316887B1
公开(公告)日：2020-04-08
申请号：EP16818780.5
申请日：2016-06-30
发明人： LEWIS, Richard, Thomas , JONES, Philip , PETROCCHI, Alessia , REYNA, Naphtali , HAMILTON, Matthew , SOTH, Michael, J. , HEFFERNAN, Timothy , HAN, Michelle , BURKE, Jason, P.
IPC分类号： A61K31/501 , A61K31/433 , A61K31/4439 , A61P35/00 , C07D401/14 , C07D403/14 , C07D417/14
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公开(公告)号：EP3164394B1
公开(公告)日：2020-04-01
申请号：EP15814723.1
申请日：2015-07-02
发明人： DI FRANCESCO, Maria, Emilia , JONES, Philip , HEFFERNAN, Timothy , HAMILTON, Matthew , KANG, Zhijun , SOTH, Michael, P. , BURKE, Jason, P. , LE, Kang , CARROLL, Christopher, Lawrence , PALMER, Wylie , LEWIS, Richard , MCAFOOS, Timothy , CZAKO, Barbara , LIU, Gang , THEROFF, Jay , HERRERA, Zachary , YAU, Anne
IPC分类号： C07D401/14 , C07D405/14 , A61K45/06 , A61K31/4192 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/501 , C07D403/14 , C07D417/06 , C07D417/14 , C07D493/08 , C07D403/06
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公开(公告)号：EP3697764A1
公开(公告)日：2020-08-26
申请号：EP18868394.0
申请日：2018-10-18
IPC分类号： C07D247/00 , C07D419/00 , G01N33/50 , G01N33/53 , G01N33/574
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公开(公告)号：EP3164394A2
公开(公告)日：2017-05-10
申请号：EP15814723.1
申请日：2015-07-02
发明人： DI FRANCESCO, Maria, Emilia , JONES, Philip , HEFFERNAN, Timothy , HAMILTON, Matthew , KANG, Zhijun , SOTH, Michael, P. , BURKE, Jason, P. , LE, Kang , CARROLL, Christopher, Lawrence , PALMER, Wylie , LEWIS, Richard , MCAFOOS, Timothy , CZAKO, Barbara , LIU, Gang , THEROFF, Jay , HERRERA, Zachary , YAU, Anne
IPC分类号： C07D401/06
摘要： Methods of inhibition GLS1 activity in a human or animal subject are also provided.
摘要翻译： 本文公开了用于治疗具有式I结构的GLS1介导的疾病例如癌症的化合物和组合物：还提供了抑制人或动物受试者中的GLS1活性的方法。
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公开(公告)号：EP3164195A1
公开(公告)日：2017-05-10
申请号：EP15814655.5
申请日：2015-07-03
发明人： HEFFERNAN, Timothy , TONIATTI, Carlo , KOVACS, Jeffrey , GIULIANI, Virginia , SPENCER, Nakia , DI FRANCESCO, Maria Emilia , BRISTOW, Christopher A.
IPC分类号： A61P39/06
CPC分类号： A61K31/501 , A61K31/433 , A61K31/4439
摘要： Disclosed herein are methods of treating a subject having an altered NRF2/KEAP1 pathway, and compounds and compositions useful in such treatment. Also disclosed herein are methods of evaluating whether to administer a compound that inhibits glutathione production or a glutaminase inhibitor to a subject.
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