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公开(公告)号：EP2170283B1
公开(公告)日：2019-01-09
申请号：EP08771657.7
申请日：2008-06-20
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公开(公告)号：EP0855906B1
公开(公告)日：2008-02-20
申请号：EP96936782.0
申请日：1996-10-17
发明人： HENRIKSEN, Inge, B. , MISHRA, Awadesh, K. , PACE, Gary, W. , JOHNSTON, Keith, P. , MAWSON, Simon
IPC分类号： A61K9/14
CPC分类号： B01J3/008 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1688 , B01F1/00 , B01F3/1214 , B01F3/1271 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , Y02P20/544 , Y10S977/896 , Y10S977/906
摘要： Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.
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3.发明公开PROCESS FOR PRODUCTION OF NANOPARTICLES AND MICROPARTICLES BY SPRAY FREEZING INTO LIQUID 审中-公开纳米和微米颗粒通过喷雾冷却在液体制造工艺
公开(公告)号：EP1357900A2
公开(公告)日：2003-11-05
申请号：EP02709265.9
申请日：2002-01-30
发明人： WILLIAMS, Robert, O., III , JOHNSTON, Keith, P. , YOUNG, Timothy, J. , ROGERS, True, L. , BARRON, Melisa, K. , YU, Zhongshui , HU, Jiahui
IPC分类号： A61K9/16
CPC分类号： F26B5/065 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/1688 , A61K9/1694 , F25B19/005 , F25C1/00 , F25D2400/30 , F26B3/08
摘要： The present invention provides a system and a method for the production of microparticles and nanoparticles of materials that can be dissolved. The system and method of the present invention provide quicker freezing times, which in turn produces a more uniform distribution of particle sizes, smaller particles, particles with increased porosity and a more intimate mixing of the particle components. The system and method of the present invention also produce particles with greater surface area than conventional methods. One form of the present invention provides a method for the preparation of particles. An effective ingredient is mixed with water, one or more solvents, or a combination thereof, and the resulting mixture is sprayed through an insulating nozzle located at or below the level of a cryogenic liquid. The spray generates frozen particles.
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公开(公告)号：EP2683362A2
公开(公告)日：2014-01-15
申请号：EP12755064.8
申请日：2012-03-09
发明人： JOHNSTON, Keith, P. , MAYNARD, Jennifer, A. , MILLER, Andrea , WILSON, Brian , TRUSKETT, Thomas, M. , DININ, Aileen , BORWANKAR, Ameya
CPC分类号： C07K16/00 , A61K9/0019 , A61K9/19 , A61K47/10 , A61K47/16 , A61K47/183 , A61K47/26 , A61K47/6881
摘要： Provided herein, inter alia, are protein dispersions comprising dense protein nanoclusters and methods of making the. Upon dilution, the clusters may reversibly dissociate into native protein molecules with high biological activity. The viscosities of the nanocluster dispersions may be sufficiently low to allow small-volume subcutaneous injections.
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5.发明公开FORMATION OF STABLE SUBMICRON PEPTIDE OR PROTEIN PARTICLES BY THIN FILM FREEZING 审中-公开形成稳定的亚微米多肽或蛋白质颗粒采用薄膜冻结
公开(公告)号：EP2170283A1
公开(公告)日：2010-04-07
申请号：EP08771657.7
申请日：2008-06-20
IPC分类号： A61K9/14
CPC分类号： A61K9/1682 , A61K9/1658 , B01D9/005 , Y10T428/2982
摘要： The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.
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公开(公告)号：EP2376522A2
公开(公告)日：2011-10-19
申请号：EP09826617.4
申请日：2009-11-10
CPC分类号： A61K9/0019 , A61K38/385 , C07K1/113
摘要： The present invention also provides a high concentration low viscosity suspension of an pharmaceutically acceptable solvent with one or more sub-micron or micron-sized non-crystalline particles comprising one or more proteins or peptides. Optionally one or more additives in the pharmaceutically acceptable solvent to form a high concentration low viscosity suspension with a concentration of at least 20 mg/ml and a solution viscosity of between 2 and 100 centipoise that is suspendable upon shaking or agitation, wherein upon delivery the one or more sub-micron or micron-sized peptides dissolves and do not form peptide aggregates syringeable through a 21 to 27-gauge needle.
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7.发明公开ENHANCED DELIVERY OF DRUG COMPOSITIONS TO TREAT LIFE THREATENING INFECTIONS 审中-公开对于生命的威胁治疗感染的组合物药物的提高，交货期
公开(公告)号：EP1789018A1
公开(公告)日：2007-05-30
申请号：EP05804416.5
申请日：2005-08-26
发明人： HITT, James, E. , ROGERS, True, L. , GILLESPIE, Ian, B. , SCHERZER, Brian, D. , GARCIA, Paula, C. , BECK, Nicholas, S. , TUCKER, Christopher, J. , YOUNG, Timothy, J. , HAYES, David, A. , WILLIAMS, Robert, O., III , JOHNSTON, Keith, P. , MCCONVILLE, Jason, T. , PETERS, Jay, I. , TALBERT, Robert , BURGESS, David
IPC分类号： A61K9/12 , A61K31/496
CPC分类号： A61K31/496 , A61K9/0073 , A61K9/008 , A61K9/19
摘要： Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (Cmax) of at least about 0.25 μg/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.
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8.发明授权PREPARATION OF DRUG PARTICLES USING EVAPORATION PRECIPITATION INTO AQUEOUS SOLUTIONS 有权活性粒子通过在水溶液中蒸发降水生产
公开(公告)号：EP1335705B1
公开(公告)日：2004-12-15
申请号：EP01989339.5
申请日：2001-10-22
IPC分类号： A61K9/14
CPC分类号： B82Y5/00 , A61K9/1694
摘要： A method for preparing poorly water soluble drug particles is disclosed. The method comprises dissolving a drug in at least one organic solvent to form a drug/organic mixture, spraying the drug/organic mixture into an aqueous solution and concurrently evaporating the organic solvent in the presence of the aqueous solution to form an aqueous dispersion of the drug particles. The resulting drug particles are in the nanometer to micrometer size range and show enhanced dissolution rates and reduced crystallinity when compared to the unprocessed drug.
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9.发明授权DISPERSION COMPOSITIONS WITH NONIONIC SURFACTANTS FOR USE IN PETROLEUM RECOVERY 有权分散体组合物与石油生产非离子表面活性
公开(公告)号：EP2451889B1
公开(公告)日：2016-03-23
申请号：EP09789168.3
申请日：2009-08-19
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公开(公告)号：EP2346924A1
公开(公告)日：2011-07-27
申请号：EP09737484.7
申请日：2009-08-19
发明人： SANDERS, Aaron, W. , JOHNSTON, Keith, P. , NGUYEN, Quoc , ADKINS, Stephanie , CHEN, Xi , RIGHTOR, Ed, G.
IPC分类号： C08G65/00
CPC分类号： C09K8/584 , C08G65/2609 , E21B43/16
摘要： Embodiments of the present disclosure include compositions for use in enhanced oil recovery, and methods of using the compositions for recovering oil. Compositions of the present disclosure include a nonionic, non-emulsifying surfactant having a CO2-philicity in a range of about 1.5 to about 5.0, carbon dioxide in a liquid phase or supercritical phase, and water, where the nonionic, non-emulsifying surfactant promotes a formation of a stable foam formed of carbon dioxide and water.
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