公开(公告)号：EP1357900A2

公开(公告)日：2003-11-05

申请号：EP02709265.9

申请日：2002-01-30

申请人： Board of Regents,The University of Texas System

发明人： WILLIAMS, Robert, O., III ,  JOHNSTON, Keith, P. ,  YOUNG, Timothy, J. ,  ROGERS, True, L. ,  BARRON, Melisa, K. ,  YU, Zhongshui ,  HU, Jiahui

IPC分类号： A61K9/16

CPC分类号： F26B5/065 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/1652 ,  A61K9/1688 ,  A61K9/1694 ,  F25B19/005 ,  F25C1/00 ,  F25D2400/30 ,  F26B3/08

摘要： The present invention provides a system and a method for the production of microparticles and nanoparticles of materials that can be dissolved. The system and method of the present invention provide quicker freezing times, which in turn produces a more uniform distribution of particle sizes, smaller particles, particles with increased porosity and a more intimate mixing of the particle components. The system and method of the present invention also produce particles with greater surface area than conventional methods. One form of the present invention provides a method for the preparation of particles. An effective ingredient is mixed with water, one or more solvents, or a combination thereof, and the resulting mixture is sprayed through an insulating nozzle located at or below the level of a cryogenic liquid. The spray generates frozen particles.

公开(公告)号：EP1817008B1

公开(公告)日：2020-04-01

申请号：EP05858310.5

申请日：2005-11-09

申请人： Board of Regents, The University of Texas System

发明人： MILLER, Dave, A. ,  MCCONVILLE, Jason, T. ,  MCGINITY, James, W. ,  WILLIAMS, Robert, O., III

IPC分类号： A61K38/13 ,  A61K31/495 ,  A61K31/55 ,  A61K31/58 ,  A61K9/14 ,  A61K9/51 ,  A61K31/496 ,  A61K9/16

公开(公告)号：EP3193842A1

公开(公告)日：2017-07-26

申请号：EP15842831.8

申请日：2015-09-18

申请人： Board of Regents, The University of Texas System

发明人： ZHANG, Feng ,  MILLER, Abbe ,  HUANG, Siyuan ,  WILLIAMS, Robert, O., III

IPC分类号： A61K9/20 ,  A61K47/38 ,  B29C47/10 ,  C08B11/08

CPC分类号： A61K31/4184 ,  A61J3/10 ,  A61K9/1635 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2095 ,  A61K31/192 ,  B29C47/0007 ,  B29K2105/0035 ,  B29K2995/0059 ,  C08L1/02 ,  C08L1/284

摘要： Compositions and methods of preparing amorphous drug formulations through hot melt extrusion which result in decreased decomposition of the desired drug are provided herein. Also provided are methods and compositions which further comprise a pharmaceutically acceptable thermoplastic polymer. In some embodiments, these compositions comprise a therapeutically active agent which is only sparingly soluble in water.

摘要翻译： 本文提供了通过热熔挤出制备无定形药物制剂的组合物和方法，其导致所需药物的分解减少。 还提供了进一步包含药学上可接受的热塑性聚合物的方法和组合物。 在一些实施方案中，这些组合物包含仅微溶于水的治疗活性剂。

公开(公告)号：EP4384215A1

公开(公告)日：2024-06-19

申请号：EP22786669.6

申请日：2022-08-11

申请人： Board of Regents, The University of Texas System

发明人： CUI, Zhengrong ,  WILLIAMS, Robert, O., III ,  ABOULFOTOUH, Khaled ,  MOON, Chaeho ,  XU, Haiyue

IPC分类号： A61K39/39 ,  A61J3/02 ,  A61K47/44 ,  A61P37/04 ,  C12N7/00

CPC分类号： A61K39/39 ,  A61K2039/54120130101 ,  A61K2039/5556620130101 ,  A61P37/04 ,  A61J3/02 ,  A61K9/1623 ,  C07K14/005 ,  C12N2760/1613420130101 ,  C12N2760/1612220130101 ,  C12N2760/1622220130101 ,  C12N2760/1623420130101 ,  C12N2770/2003420130101 ,  C12N2770/2002220130101 ,  A61K39/12 ,  C12N2710/2002220130101 ,  C12N2710/2003420130101 ,  C12N2730/1012220130101 ,  C12N2730/1013420130101

公开(公告)号：EP3849581A1

公开(公告)日：2021-07-21

申请号：EP19859836.9

申请日：2019-09-10

申请人： Board of Regents, The University of Texas System ,  Lung Therapeutics, Inc.

发明人： WILLIAMS, Robert, O., III ,  WATTS, Alan, B. ,  ZHANG, Yajie ,  SAHAKIJPIJARN, Sawittree ,  CHRISTENSEN, Dale ,  KOLENG, John, J.

IPC分类号： A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  A61K38/17 ,  A61P11/00 ,  C07K7/06

公开(公告)号：EP2187968A2

公开(公告)日：2010-05-26

申请号：EP08798412.6

申请日：2008-08-21

申请人： Board of Regents, The University of Texas System

发明人： BROUGH, Chris ,  MCGINITY, James, W. ,  MILLER, Dave, A. ,  DINUNZIO, James, C. ,  WILLIAMS, Robert, O., III

IPC分类号： A61K47/00 ,  A61K9/20 ,  A61K9/24

CPC分类号： A61K31/573 ,  A61J3/00 ,  A61J3/07 ,  A61J3/10 ,  A61K9/146 ,  A61K9/1694 ,  A61K9/2077 ,  A61K31/343 ,  A61K31/496 ,  A61K47/32 ,  A61K47/38

摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

公开(公告)号：EP1789018A1

公开(公告)日：2007-05-30

申请号：EP05804416.5

申请日：2005-08-26

申请人： THE DOW CHEMICAL COMPANY ,  Board of Regents, The University of Texas System

发明人： HITT, James, E. ,  ROGERS, True, L. ,  GILLESPIE, Ian, B. ,  SCHERZER, Brian, D. ,  GARCIA, Paula, C. ,  BECK, Nicholas, S. ,  TUCKER, Christopher, J. ,  YOUNG, Timothy, J. ,  HAYES, David, A. ,  WILLIAMS, Robert, O., III ,  JOHNSTON, Keith, P. ,  MCCONVILLE, Jason, T. ,  PETERS, Jay, I. ,  TALBERT, Robert ,  BURGESS, David

IPC分类号： A61K9/12 ,  A61K31/496

CPC分类号： A61K31/496 ,  A61K9/0073 ,  A61K9/008 ,  A61K9/19

摘要： Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (Cmax) of at least about 0.25 μg/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.

公开(公告)号：EP3065705A2

公开(公告)日：2016-09-14

申请号：EP14857307.4

申请日：2014-11-04

申请人： Board of Regents, The University of Texas System

发明人： WILLIAMS, Robert, O., III ,  IDELL, Steven

IPC分类号： A61K9/12

CPC分类号： A61K38/49 ,  A61K9/0078 ,  A61K9/008 ,  C12Y304/21073

摘要： Methods and composition for delivery of enzymes to a subject's airway. In some aspects, nebulized composition of enzymes, such as plasminogen activators are provided. In further aspects perfluorocarbon compositions comprising enzymes, such as plasminogen activators are provided. Compositions may, in some aspects, be used for the treatment of lung infections or acute lung injury, such as inhalational smoke induced acute lung injury (ISALI).

摘要翻译： 方法和组成交货酶对受试者的气道。 在一些方面中，酶的雾化的组合物，纤溶酶原激活剂：如被提供。 在另外的方面的全氟化碳组合物，包含酶，纤溶酶原激活剂：如被提供。 组合物可以，在一些方面，用于肺部感染或急性肺损伤,:如吸入烟雾诱导的急性肺损伤（Isali）的治疗。

公开(公告)号：EP2124898B1

公开(公告)日：2013-08-14

申请号：EP08780367.2

申请日：2008-01-10

申请人： Board of Regents, The University of Texas System ,  The Dow Chemical Company

发明人： WILLIAMS, Robert, O., III ,  JOHNSTON, Keith, P. ,  SINWAT, Prapasri ,  MCCONVILLE, Jason, T. ,  TALBERT, Robert ,  PETERS, Jay ,  WATTS, Alan, B. ,  ROGERS, True, L.

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/00 ,  A61K9/19

CPC分类号： A61K31/436 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/1623 ,  A61K9/1694 ,  A61K9/19 ,  A61K9/5161 ,  A61K9/5192 ,  A61K38/13

摘要： The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.

公开(公告)号：EP2124898A1

公开(公告)日：2009-12-02

申请号：EP08780367.2

申请日：2008-01-10

申请人： Board of Regents, The University of Texas System ,  The Dow Chemical Company

发明人： WILLIAMS, Robert, O., III ,  JOHNSTON, Keith, P. ,  SINWAT, Prapasri ,  MCCONVILLE, Jason, T. ,  TALBERT, Robert ,  PETERS, Jay ,  WATTS, Alan, B. ,  ROGERS, True, L.

IPC分类号： A61K9/14

CPC分类号： A61K31/436 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/1623 ,  A61K9/1694 ,  A61K9/19 ,  A61K9/5161 ,  A61K9/5192 ,  A61K38/13

摘要： The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.

摘要翻译： 本发明包括用于制备和使用快速溶解，高效力，基本上无定形纳米结构化聚集体用于肺移植他克莫司的组合物和方法，以及包含任选的聚合物或非聚合物表面活性剂，聚合物或非聚合物糖的稳定剂基质 或两者，其中所述骨料包含通过BET分析测量的大于5m 2 / g的表面积，并且当将他克莫司的水溶液结晶溶解度加入到模拟肺液中时，表现出过饱和至少0.5小时。