公开(公告)号：EP2483274B1

公开(公告)日：2014-10-29

申请号：EP10821105.3

申请日：2010-09-28

申请人： Board of Regents, The University of Texas System ,  Monash University ,  MMV Medicines for Malaria Venture ,  University of Washington ,  Glaxosmithkline Investigacion y Desarrollo, S.L.

发明人： RATHOD, Pradipsinh, K. ,  FLOYD, David ,  BURROWS, Jeremy ,  MARWAHA, Alka ,  GUJJAR, Ramesh ,  COTERON-LOPEZ, Jose ,  PHILLIPS, Margaret ,  CHARMAN, Susan, A. ,  MATTHEWS, David

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P33/06

CPC分类号： C07D487/04

公开(公告)号：EP2483274A2

公开(公告)日：2012-08-08

申请号：EP10821105.3

申请日：2010-09-28

申请人： Board of Regents, The University of Texas System ,  Monash University ,  Medicines For Malaria Venture ,  University of Washington ,  Glaxosmithkline Investigacion y Desarrollo, S.L.

发明人： RATHOD, Pradipsinh, K. ,  FLOYD, David ,  BURROWS, Jeremy ,  MARWAHA, Alka ,  GUJJAR, Ramesh ,  COTERON-LOPEZ, Jose ,  PHILLIPS, Margaret ,  CHARMAN, Susan, A. ,  MATTHEWS, David

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P33/06

CPC分类号： C07D487/04

摘要： Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula (IX): and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.

公开(公告)号：EP2203457B1

公开(公告)日：2014-03-05

申请号：EP08845311.3

申请日：2008-10-29

申请人： MMV Medicines for Malaria Venture

发明人： VENNERSTROM, Jonathan, L. ,  DONG, Yuxiang ,  CHARMAN, Susan, A. ,  WITTLIN, Sergio ,  CHOLLET, Jacques ,  CREEK, Darren, J. ,  WANG, Xiaofang ,  SRIRAGHAVAN, Kamaraj ,  ZHOU, Lin ,  MATILE, Hugues ,  CHARMAN, William, N.

IPC分类号： C07D493/10 ,  A61K31/343 ,  A61K31/4525 ,  A61K31/496 ,  A61P33/06 ,  A61K31/553 ,  A61K31/5377 ,  A61K31/541

CPC分类号： C07D493/10 ,  C07D323/02 ,  C07D405/12 ,  C07D413/12