公开(公告)号：EP2483274B1

公开(公告)日：2014-10-29

申请号：EP10821105.3

申请日：2010-09-28

申请人： Board of Regents, The University of Texas System ,  Monash University ,  MMV Medicines for Malaria Venture ,  University of Washington ,  Glaxosmithkline Investigacion y Desarrollo, S.L.

发明人： RATHOD, Pradipsinh, K. ,  FLOYD, David ,  BURROWS, Jeremy ,  MARWAHA, Alka ,  GUJJAR, Ramesh ,  COTERON-LOPEZ, Jose ,  PHILLIPS, Margaret ,  CHARMAN, Susan, A. ,  MATTHEWS, David

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P33/06

CPC分类号： C07D487/04

公开(公告)号：EP2483274A2

公开(公告)日：2012-08-08

申请号：EP10821105.3

申请日：2010-09-28

申请人： Board of Regents, The University of Texas System ,  Monash University ,  Medicines For Malaria Venture ,  University of Washington ,  Glaxosmithkline Investigacion y Desarrollo, S.L.

发明人： RATHOD, Pradipsinh, K. ,  FLOYD, David ,  BURROWS, Jeremy ,  MARWAHA, Alka ,  GUJJAR, Ramesh ,  COTERON-LOPEZ, Jose ,  PHILLIPS, Margaret ,  CHARMAN, Susan, A. ,  MATTHEWS, David

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P33/06

CPC分类号： C07D487/04

摘要： Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula (IX): and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.

公开(公告)号：EP3022200B1

公开(公告)日：2017-03-01

申请号：EP14759317.2

申请日：2014-07-17

申请人： MMV Medicines for Malaria Venture ,  Drexel University ,  University of Washington

发明人： BURROWS, Jeremy ,  WYVRATT, Matthew ,  VAIDYA, Akhil ,  KORTAGERE, Sandhya ,  FAN, Erkang ,  CHATTERJEE, Arnab Kumar ,  NAGLE, Advait Suresh ,  KATO, Tomoyo

IPC分类号： C07D403/12 ,  C07D231/40 ,  A61K31/415 ,  A61K31/4184 ,  A61P33/06

CPC分类号： C07D231/40 ,  A61K31/415 ,  A61K31/4184 ,  A61K45/06 ,  C07D403/12

公开(公告)号：EP3022200A1

公开(公告)日：2016-05-25

申请号：EP14759317.2

申请日：2014-07-17

申请人： MMV Medicines for Malaria Venture ,  Drexel University ,  University of Washington

发明人： BURROWS, Jeremy ,  WYVRATT, Matthew ,  VAIDYA, Akhil ,  KORTAGERE, Sandhya ,  FAN, Erkang ,  CHATTERJEE, Arnab Kumar ,  NAGLE, Advait Suresh ,  KATO, Tomoyo

IPC分类号： C07D403/12 ,  C07D231/40 ,  A61K31/415 ,  A61K31/4184 ,  A61P33/06

CPC分类号： C07D231/40 ,  A61K31/415 ,  A61K31/4184 ,  A61K45/06 ,  C07D403/12

摘要： The present invention is related to a use of pyrazole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to pyrazole derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

摘要翻译： 本发明涉及吡唑衍生物在制备用于预防或治疗疟疾的药物中的用途。 具体地，本发明涉及可用于制备用于抑制疟疾寄生虫增殖的药物制剂的吡唑衍生物。

公开(公告)号：EP2370411A2

公开(公告)日：2011-10-05

申请号：EP09831228.3

申请日：2009-12-04

申请人： Oregon Health and Science University ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA D.B.A THE DEPARTMENT OF VETERANS AFFAIRS ,  University Of South Florida ,  Medicines for Malaria Venture

发明人： RISCOE, Michael,K. ,  KELLY, Jane, X. ,  WINTER, Rolf, W. ,  HINRICHS, David, J. ,  SMILKSTEIN, Martin, J. ,  NILSEN, Aaron ,  MONASTYRSKYI, Andrii ,  CROSS, Richard M. ,  BURROWS, Jeremy ,  KYLE, Dennis ,  MANETSCH, Roman ,  FLANIGAN, David L.

IPC分类号： C07D215/04 ,  C07D403/04 ,  C07D403/12 ,  A61P31/04

CPC分类号： C07D215/60 ,  C07D215/233 ,  C07D215/42 ,  C07D239/90 ,  C07D279/16 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D413/04 ,  C07D491/052

摘要： A method for inhibiting a parasitic or infectious disease in a subject, wherein the parasitic or infectious disease is selected from one caused by Eimeria sp., Babesia sp., Theileria sp. or Neospora caninum, the method comprising administering to the subject a therapeutically effective amount of a compound of formula I: or formula II: or a pharmaceutically acceptable salt of formula I or formula II, wherein: R1 is H, hydroxyl, alkoxy, acyl, alkyl, cycloalkyl, aryl, or heteroaryl; R2 is methyl, haloalkyl, or heteroaryl; R4 is hydroxyl, carbonyloxy, or carbonyldioxy; R3 is aliphatic, aryl, aralkyl, or alkylaryl; and R5, R6, R7 and R8 are each individually H, halogen, alkoxy, alkyl, haloalkyl, aryl, nitro, cyano, amino, amido, acyl, carboxyl, substituted carboxyl, or —SO2R10, wherein R10 is H, alkyl, amino or haloalkyl; provided that in formula I, R5 and R7 are not H or R6 is not H or methoxy; and in formula II that if R4 is carbonyldioxy then R7 is not methoxy.

公开(公告)号：EP4132918A1

公开(公告)日：2023-02-15

申请号：EP21717085.1

申请日：2021-04-08

申请人： University Of Kentucky Research Foundation ,  MMV Medicines for Malaria Venture

发明人： GUY, Rodney Kiplin ,  HAMMILL, Jared T. ,  FLOYD, David ,  BURROWS, Jeremy ,  BRAND, Stephen

IPC分类号： C07D401/04 ,  C07D403/04 ,  A61P33/06 ,  A61K31/4725 ,  A61K31/506

公开(公告)号：EP3892332A1

公开(公告)日：2021-10-13

申请号：EP20169099.7

申请日：2020-04-09

申请人： University Of Kentucky Research Foundation ,  MMV Medicines for Malaria Venture

发明人： GUY, Rodney Kiplin ,  HAMMILL, Jared T. ,  FLOYD, David ,  BURROWS, Jeremy ,  BRAND, Stephen

IPC分类号： A61P33/06 ,  C07D401/04 ,  C07D403/04 ,  A61K31/4725 ,  A61K31/506

摘要： The present invention is related to new derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to dihydroisoquinoline derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.