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1.发明授权MEDICAMENTS FOR INHALATION COMPRISING BETAMIMETICS AND AN ANTICHOLINERGIC AGENT 有权药物雾化吸入和β受体兴奋剂抗胆碱能
公开(公告)号：EP1651221B1
公开(公告)日：2009-01-14
申请号：EP04741115.2
申请日：2004-07-17
发明人： GERMEYER, Sabine , MEADE, Christopher, John, Montague , MEISSNER, Helmut , MORSCHHAEUSER, Gerd , PAIRET, Michel , PESTEL, Sabine , PIEPER, Michael, P. , POHL, Gerald , REICHL, Richard , SPECK, Georg , KONETZKI, Ingo
IPC分类号： A61K31/46 , A61K31/167 , A61K31/137 , A61K31/00 , A61P11/06 , A61K9/00
CPC分类号： A61K9/0075 , A61K9/008 , A61K31/00 , A61K31/137 , A61K31/167 , A61K31/46 , A61K2300/00
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公开(公告)号：EP3174876B1
公开(公告)日：2019-12-18
申请号：EP15742316.1
申请日：2015-07-30
发明人： GNAMM, Christian , ANDERSKEWITZ, Ralf , HOESCH, Holger , MORSCHHAEUSER, Gerd , OOST, Thorsten , PETERS, Stefan , RIES, Uwe Joerg
IPC分类号： C07D471/04 , A61P1/00 , A61P11/00
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公开(公告)号：EP3174863B1
公开(公告)日：2018-12-05
申请号：EP15744911.7
申请日：2015-07-30
发明人： PETERS, Stefan , ANDERSKEWITZ, Ralf , GNAMM, Christian , HOESCH, Holger , MORSCHHAEUSER, Gerd , OOST, Thorsten , RIES, Uwe Joerg
IPC分类号： C07D239/70 , A61K31/517 , A61P29/00 , C07D401/10 , C07D403/10 , C07D405/12 , C07D413/10
CPC分类号： C07D239/70 , C07D401/10 , C07D403/10 , C07D405/12 , C07D413/10
摘要： Substituted dihydropyrimidinones of formula 1 which are neutrophil elastase inhibitors and useful as medicaments for the treatment of, inter alia, COPD. Exemplary is
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4.发明授权
公开(公告)号：EP3174860B1
公开(公告)日：2018-09-19
申请号：EP15744231.0
申请日：2015-07-30
IPC分类号： C07D239/22 , A61K31/513 , A61P29/00 , C07D401/10 , C07D403/10 , C07D405/12 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04 , C07D498/04 , C07D498/08
CPC分类号： C07D239/22 , A61K31/513 , C07D401/10 , C07D403/10 , C07D405/12 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04 , C07D498/04 , C07D498/08
摘要： Substituted dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase activity and which are useful as medicaments for the treatment of, inter alia, COPD. Exemplary is
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5.发明公开
公开(公告)号：EP3604308A1
公开(公告)日：2020-02-05
申请号：EP19191493.6
申请日：2015-07-30
发明人： GNAMM, Christian , ANDERSKEWITZ, Ralf , HOESCH, Holger , MORSCHHAEUSER, Gerd , OOST, Thorsten , PETERS, Stefan , RIES, Uwe Joerg
IPC分类号： C07D471/04 , A61K45/06 , A61K31/517 , A61P9/10 , A61P43/00
摘要： This invention relates to substituted bicyclic dihydropyrimidinones of formula 1
and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.-
6.发明公开SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY 审中-公开取代的双环二氢嘧啶酮及其作为中性粒细胞弹性蛋白酶活性抑制剂的应用
公开(公告)号：EP3174862A1
公开(公告)日：2017-06-07
申请号：EP15744232.8
申请日：2015-07-30
发明人： OOST, Thorsten , ANDERSKEWITZ, Ralf , GNAMM, Christian , MORSCHHAEUSER, Gerd , PETERS, Stefan , RIES, Uwe Joerg
IPC分类号： C07D239/70 , A61K31/517 , A61P29/00
CPC分类号： C07D239/82 , C07D239/70
摘要： Substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity. An exemplary compound is
摘要翻译： 式1的取代的双环二氢嘧啶酮及其作为嗜中性粒细胞弹性蛋白酶活性抑制剂的用途。 示例性的化合物是
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7.发明公开SUBSTITUTED DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY 审中-公开替代维生素D二烯雌二醇在德国维尔多斯ALS INHIBITOREN DERAKTIVITÄTNEUTROPHILER ELASTASE
公开(公告)号：EP3174860A1
公开(公告)日：2017-06-07
申请号：EP15744231.0
申请日：2015-07-30
IPC分类号： C07D239/22 , A61K31/513 , A61P29/00
CPC分类号： C07D239/22 , A61K31/513 , C07D401/10 , C07D403/10 , C07D405/12 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04 , C07D498/04 , C07D498/08
摘要： Substituted dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase activity and which are useful as medicaments for the treatment of, inter alia, COPD. Exemplary is
摘要翻译： 式1的取代的二氢嘧啶酮，其是嗜中性粒细胞弹性蛋白酶活性的抑制剂，并且其可用作用于治疗特别是COPD的药物。 示例性的
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8.发明公开MEDICAMENTS COMPRISING PDE IV INHIBITORS AND A NOVEL ANTICHOLINERGIC AND THEIR USE FOR TREATING RESPIRATORY DISORDERS 审中-公开产品含PDE IV抑制剂和抗胆碱能药NEW及其用于呼吸系统疾病的治疗
公开(公告)号：EP1651208A1
公开(公告)日：2006-05-03
申请号：EP04741118.6
申请日：2004-07-23
发明人： GERMEYER, Sabine , MEADE, Christopher, John, Montague , MEISSNER, Helmut , MORSCHHAEUSER, Gerd , PAIRET, Michel , PESTEL, Sabine , PIEPER, Michael, P. , POHL, Gerald , REICHL, Richard , SPECK, Georg
IPC分类号： A61K31/335 , A61K31/192 , A61K31/44 , A61P11/00 , A61K45/06 , A61K31/46
CPC分类号： A61K9/0075 , A61K9/0078 , A61K9/008 , A61K31/192 , A61K31/335 , A61K31/4015 , A61K31/44 , A61K31/46 , A61K31/4745 , A61K45/06 , A61K2300/00
摘要： The present invention relates to novel pharmaceutical compositions based on PDE IV inhibitors and salts of a new anticholinergic, processes for preparing them and their use in the treatment of respiratory complaints.
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9.发明公开SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY 审中-公开取代的双环二氢嘧啶酮及其作为中性粒细胞弹性蛋白酶活性抑制剂的应用
公开(公告)号：EP3174861A1
公开(公告)日：2017-06-07
申请号：EP15744229.4
申请日：2015-07-30
发明人： OOST, Thorsten , ANDERSKEWITZ, Ralf , GNAMM, Christian , HOESCH, Holger , MORSCHHAEUSER, Gerd , PETERS, Stefan , RIES, Uwe Joerg
IPC分类号： C07D239/70 , A61K31/517 , A61P29/00
CPC分类号： C07D239/70 , C07D401/04
摘要： Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase and useful as medicaments for the treatment of, inter alia, COPD. An exemplary compound is:
摘要翻译： 式1的取代的双环二氢嘧啶酮是嗜中性粒细胞弹性蛋白酶的抑制剂并且可用作用于治疗COPD等的药物。 示例性化合物是：
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10.发明授权SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C 有权取代的2-氮杂双环[2.2.1]庚烷-3-羧酸（氰基 - 甲基） - 酰胺类抑制剂
公开(公告)号：EP2970228B1
公开(公告)日：2017-05-10
申请号：EP14709317.3
申请日：2014-03-12
IPC分类号： C07D405/14 , A61K31/439 , C07D221/22 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/08 , A61P11/06 , A61P37/08 , A61P37/06 , A61P9/10
CPC分类号： C07D409/12 , A61K45/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14
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