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1.发明公开
公开(公告)号：EP3604308A1
公开(公告)日：2020-02-05
申请号：EP19191493.6
申请日：2015-07-30
发明人： GNAMM, Christian , ANDERSKEWITZ, Ralf , HOESCH, Holger , MORSCHHAEUSER, Gerd , OOST, Thorsten , PETERS, Stefan , RIES, Uwe Joerg
IPC分类号： C07D471/04 , A61K45/06 , A61K31/517 , A61P9/10 , A61P43/00
摘要： This invention relates to substituted bicyclic dihydropyrimidinones of formula 1
and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.-
2.发明公开SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY 审中-公开取代的双环二氢嘧啶酮及其作为中性粒细胞弹性蛋白酶活性抑制剂的应用
公开(公告)号：EP3174862A1
公开(公告)日：2017-06-07
申请号：EP15744232.8
申请日：2015-07-30
发明人： OOST, Thorsten , ANDERSKEWITZ, Ralf , GNAMM, Christian , MORSCHHAEUSER, Gerd , PETERS, Stefan , RIES, Uwe Joerg
IPC分类号： C07D239/70 , A61K31/517 , A61P29/00
CPC分类号： C07D239/82 , C07D239/70
摘要： Substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity. An exemplary compound is
摘要翻译： 式1的取代的双环二氢嘧啶酮及其作为嗜中性粒细胞弹性蛋白酶活性抑制剂的用途。 示例性的化合物是
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3.发明公开SUBSTITUTED PYRIDONES AND PYRAZINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY 审中-公开取代的吡啶酮和吡嗪及其作为中性粒细胞弹性蛋白酶抑制剂的
公开(公告)号：EP3107911A1
公开(公告)日：2016-12-28
申请号：EP15705807.4
申请日：2015-02-17
发明人： GNAMM, Christian , OOST, Thorsten
IPC分类号： C07D405/14 , C07D401/04 , C07D403/04 , A61K31/497 , A61K31/4439 , A61K31/5377 , A61P29/00
CPC分类号： C07D413/14 , C07D401/04 , C07D403/04 , C07D405/14
摘要： Substituted 2-pyridones and pyrazinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other auto-immune and allergic disorders, allograft rejection and oncological diseases.
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4.发明公开SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY 有权取代的双环二氢嘧啶及其作为活性弹性蛋白酶的抑制剂
公开(公告)号：EP2964617A1
公开(公告)日：2016-01-13
申请号：EP14706627.8
申请日：2014-02-26
发明人： GNAMM, Christian , OOST, Thorsten , PETERS, Stefan , RUDOLF, Klaus , HOESCH, Holger , RIES, Uwe Jörg
IPC分类号： C07D239/82 , C07D401/04 , C07D403/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D487/04 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/06 , C07D471/04 , C07D487/10 , C07D498/04
CPC分类号： C07D239/82 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/12 , C07D409/04 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/10 , C07D493/10 , C07D498/04 , C07D498/10
摘要： This invention relates to substituted bicyclic dihydropyrimidinones of formula (1) and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.
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公开(公告)号：EP4337326A1
公开(公告)日：2024-03-20
申请号：EP22728219.1
申请日：2022-05-09
发明人： HEIMANN, Annekatrin Charlotte , GNAMM, Christian , GODBOUT, Cédrickx , GROSS, Patrick , HANDSCHUH, Sandra Ruth , HOENKE, Christoph , KLEY, Joerg , KUTTRUFF, Christian Andreas , REINERT, Dirk , STUBER, Raphael , GRUNDL, Marc Alexander , THEIS, Theodor
IPC分类号： A61P35/00 , A61P1/00 , A61P9/00 , A61P11/00 , A61P21/00 , A61P25/16 , A61P27/02 , A61P29/00 , C07D491/048 , C07D491/107 , C07D498/04 , C07D498/10 , A61K31/519 , A61K31/5386 , A61K31/444 , C07D213/74 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/14 , C07D401/14
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公开(公告)号：EP3347353A1
公开(公告)日：2018-07-18
申请号：EP16759802.8
申请日：2016-09-02
发明人： HOFFMANN, Matthias , DAHMANN, Georg , GNAMM, Christian , FANDRICK, Daniel , SCOTT, John , MCCARTHY, Clive
IPC分类号： C07D403/12 , C07D231/56 , C07D403/14 , C07D471/04 , A61K31/437 , A61K31/416 , A61P11/00 , A61P11/06 , A61P11/08 , A61P17/00
CPC分类号： C07D403/14 , A61K31/416 , A61K31/437 , A61K45/06 , C07D231/56 , C07D403/12 , C07D405/14 , C07D471/04 , C07D493/04 , Y02A50/385 , Y02A50/411
摘要： The invention relates to new substituted heteroaryls of formula 1 or of formula 1' wherein A is either N or CH, wherein R2 is selected from the group consisting of -C1-3-alkyl, -C1-3-haloalkyl, F, Br, CI, wherein Y is selected from -O- or -CH2-, and wherein R3 is defined as in claim 1, and the pharmaceutically acceptable salts thereof, and the use of these aforementioned compounds for the treatment of diseases such as asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.
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7.发明公开SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY 审中-公开取代的双环二氢嘧啶酮及其作为中性粒细胞弹性蛋白酶活性抑制剂的应用
公开(公告)号：EP3174861A1
公开(公告)日：2017-06-07
申请号：EP15744229.4
申请日：2015-07-30
发明人： OOST, Thorsten , ANDERSKEWITZ, Ralf , GNAMM, Christian , HOESCH, Holger , MORSCHHAEUSER, Gerd , PETERS, Stefan , RIES, Uwe Joerg
IPC分类号： C07D239/70 , A61K31/517 , A61P29/00
CPC分类号： C07D239/70 , C07D401/04
摘要： Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase and useful as medicaments for the treatment of, inter alia, COPD. An exemplary compound is:
摘要翻译： 式1的取代的双环二氢嘧啶酮是嗜中性粒细胞弹性蛋白酶的抑制剂并且可用作用于治疗COPD等的药物。 示例性化合物是：
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8.发明公开SUBSTITUTED 4-PYRIDONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY 有权取代的4-吡啶酮及其作为抑制剂NEUTROPHILELASTASEAKTIVITÄT
公开(公告)号：EP2888248A1
公开(公告)日：2015-07-01
申请号：EP13756032.2
申请日：2013-08-22
发明人： OOST, Thorsten , FIEGEN, Dennis , GNAMM, Christian , HANDSCHUH, Sandra , PETERS, Stefan , ROTH, Gerald Juergen
IPC分类号： C07D409/12 , C07D401/12 , C07D413/12 , C07D213/82 , C07D405/12 , A61K31/4412 , A61P29/00
CPC分类号： C07D213/80 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D493/08
摘要： This invention relates to substituted 4-pyridones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other auto-immune and allergic disorders, allograft rejection, and oncological diseases.
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公开(公告)号：EP4337327A1
公开(公告)日：2024-03-20
申请号：EP22728222.5
申请日：2022-05-09
发明人： HEIMANN, Annekatrin Charlotte , GNAMM, Christian , GODBOUT, Cédrickx , GROSS, Patrick , HANDSCHUH, Sandra Ruth , HOENKE, Christoph , KLEY, Joerg , KUTTRUFF, Christian Andreas , REINERT, Dirk , STUBER, Raphael , GRUNDL, Marc Alexander , THEIS, Theodor
IPC分类号： A61P35/00 , A61P1/00 , A61P9/00 , A61P11/00 , A61P21/00 , A61P25/16 , A61P27/02 , A61P29/00 , C07D491/048 , C07D498/04 , A61K31/519 , A61K31/5386 , A61K31/444 , C07D401/04 , C07D405/04 , C07D409/04 , C07D495/10
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公开(公告)号：EP3347353B1
公开(公告)日：2019-07-17
申请号：EP16759802.8
申请日：2016-09-02
发明人： HOFFMANN, Matthias , DAHMANN, Georg , GNAMM, Christian , FANDRICK, Daniel , SCOTT, John , MCCARTHY, Clive
IPC分类号： C07D403/12 , C07D231/56 , C07D403/14 , C07D471/04 , A61K31/437 , A61K31/416 , A61P11/00 , A61P11/06 , A61P11/08 , A61P17/00
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