-
1.发明授权CRYSTALLINE FORMS OF HYDROCHLORIDE SALT OF (4A-R,9A-S)-1-(1H-BENZOIMIDAZOLE-5-CARBONYL)-2,3,4,4A,9,9A-HEXAHYDRO-1H-INDENO [2,1-B]PYRIDINE-6-CARBONITRILE AND THEIR USE AS HSD 1 INHIBITORS 有权（R 4A，9A-S）-1-（1个H-苯并咪唑-5-羰基）-2,3,4,4a，9,9A六氢-1H-茚并盐酸盐的结晶形式[2,1- b〕吡啶-6-甲腈和它们作为抑制剂的HSD 1
公开(公告)号：EP2635563B1
公开(公告)日：2015-01-14
申请号：EP11785232.7
申请日：2011-11-04
IPC分类号： C07D401/06 , A61K31/435 , A61P3/00
CPC分类号： C07D401/06
-
2.发明公开PROCESS FOR PREPARING A POLYMORPH OF THE CHOLINE SALT OF A PYRIMIDIN-5-YL ACETIC ACID DERIVATIVE 审中-公开用于生产胆碱的多晶型盐嘧啶-5-基 - 乙酸衍生物
公开(公告)号：EP2504319A1
公开(公告)日：2012-10-03
申请号：EP10782506.9
申请日：2010-11-19
发明人： KRISHNAMURTHY, Dhileep , RODRIGUEZ DEHLI, Juan Manuel , SCHUL, Michael , WANG, Xiao-Jun , YANG, Bing-Shiou
IPC分类号： C07D239/48 , A61K31/505 , A61P11/06
CPC分类号： C07D239/48
摘要： Provided is a process for preparing a choline salt of [4,6-bis(dimethylamino)-2-(4-{ [4- (trifluoromethyl)benzoyl] amino }benzyl)pyrimidin-5-yl] acetic acid. The process of the invention is useful for preparing the salt in purer forms of the salt. Also disclosed is a more pure form of the of choline salt of [4,6-bis(dimethylamino)-2-(4-{ [4- (trifluoromethyl)benzoyl] amino }benzyl)pyrimidin-5-yl] acetic acid.
-
3.发明公开
公开(公告)号：EP2504318A2
公开(公告)日：2012-10-03
申请号：EP10781565.6
申请日：2010-11-17
发明人： YANG, Bing-Shiou
IPC分类号： C07D239/48 , A61K31/505 , A61P11/06
CPC分类号： C07D239/48
摘要： Provided are crystalline N-methyl-glucamine and sodium salts of [4,6-bis(dimethylamino)-2-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)pyrimidin-5-yl] acetic acid, processes for their preparation, pharmaceutical compositions comprising the salts, and methods of their use for treating, preventing, or ameliorating one or more symptoms of a CRTH2-mediated disorder or disease.
-
4.发明公开CRYSTALLINE FORMS OF HYDROCHLORIDE SALT OF (4A-R,9A-S) -1- (1H - BENZOIMIDAZOLE- 5 -CARBONYL) -2, 3, 4, 4A, 9, 9A - HEXAHYDRO -1H- INDENO [2, 1 -B]PYRIDINE- 6 -CARBONITRILE AND THEIR USE AS HSD 1 INHIBITORS 有权结晶形式（4A-R，9A S）-1-（1H苯并咪唑-5-基羰基）-2,3,4,4a，9,9A六氢-1H-茚并[盐酸盐2,1- b〕吡啶-6-甲腈和它们作为抑制剂的HSD 1
公开(公告)号：EP2635563A1
公开(公告)日：2013-09-11
申请号：EP11785232.7
申请日：2011-11-04
IPC分类号： C07D401/06 , A61K31/435 , A61P3/00
CPC分类号： C07D401/06
摘要： The present invention relates to crystalline compounds of the following structural formula (II) possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11 β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
-
公开(公告)号：EP4229051A1
公开(公告)日：2023-08-23
申请号：EP21786982.5
申请日：2021-10-11
发明人： BAER, Katrin , BARTA, Albert Josef , BODENBACH, Gisela , GAO, Joe Ju , GRIMM, Julia Regina , NORDSTROM, Fredrik, Lars , WIESE, Michael , YANG, Bing-Shiou , NAKATANI, Manabu , ADACHI, Masashi , EGUSA, Kenji , MESSERSCHMID, Roman Christian , SCHROEDER, Daniela Maria
IPC分类号： C07D413/04 , A61K31/42 , A61P25/18
-
公开(公告)号：EP3962911A1
公开(公告)日：2022-03-09
申请号：EP20726654.5
申请日：2020-04-30
发明人： SIEGER, Peter , GAO, Joe Ju , YANG, Bing-Shiou
IPC分类号： C07D413/04 , A61K31/42 , A61P25/18
-
7.发明授权NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA 有权新哌啶DIHYDROTHIEN嘧啶亚砜及其用途用于治疗哮喘和COPD的治疗
公开(公告)号：EP2748156B1
公开(公告)日：2015-12-16
申请号：EP12762543.2
申请日：2012-08-17
发明人： POUZET, Pascale, A., J. , NICKOLAUS, Peter , WERTHMANN, Ulrike , FRUTOS, Rogelio, P. , YANG, Bing-Shiou , KIM, Soojin , MULDER, Jason, Alan , PATEL, Nitinchandra , SENANAYAKE, Chris, H. , TAMPONE, Thomas, G. , WEI, Xudong
IPC分类号： C07D401/04 , C07D495/04 , C07C211/35 , A61K31/519 , A61P29/00
CPC分类号： C07D495/04 , A61K31/519 , A61K45/06 , C07B2200/13 , C07C213/00 , C07D401/04 , C07C215/42
-
公开(公告)号：EP2545049B1
公开(公告)日：2015-10-14
申请号：EP11708380.8
申请日：2011-03-10
发明人： YANG, Bing-Shiou , YIP, Ka
IPC分类号： C07D417/14 , A61K31/427 , A61P31/18
CPC分类号： C07D417/14 , C07B2200/13
-
9.发明公开NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA 有权新哌啶DIHYDROTHIEN嘧啶亚砜及其用途用于治疗哮喘和COPD的治疗
公开(公告)号：EP2748156A1
公开(公告)日：2014-07-02
申请号：EP12762543.2
申请日：2012-08-17
发明人： POUZET, Pascale, A., J. , NICKOLAUS, Peter , WERTHMANN, Ulrike , FRUTOS, Rogelio, P. , YANG, Bing-Shiou , KIM, Soojin , MULDER, Jason, Alan , PATEL, Nitinchandra , SENANAYAKE, Chris, H. , TAMPONE, Thomas, G. , WEI, Xudong
IPC分类号： C07D401/04 , C07D495/04 , C07C211/35 , A61K31/519 , A61P29/00
CPC分类号： C07D495/04 , A61K31/519 , A61K45/06 , C07B2200/13 , C07C213/00 , C07D401/04 , C07C215/42
摘要： The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is CI and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
-
公开(公告)号：EP2545049A1
公开(公告)日：2013-01-16
申请号：EP11708380.8
申请日：2011-03-10
发明人： YANG, Bing-Shiou , YIP, Ka
IPC分类号： C07D417/14 , A61K31/427 , A61P31/18
CPC分类号： C07D417/14 , C07B2200/13
摘要： This invention relates to novel tris(hydroxymethyl)aminomethane, choline and N-methyl-D-glucamine salt forms of the following Compound (1) and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of Hepatitis C Viral (HCV) infection:
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.013 秒)
