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1.发明授权DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES 有权[ - - 1,2-a]咪唑-3-羧酸酰胺的6,7-二氢-5H-咪唑并衍生物
公开(公告)号：EP2225238B1
公开(公告)日：2014-09-03
申请号：EP08853791.5
申请日：2008-11-20
发明人： LEMIEUX, Rene M. , BARBOSA, Antonio Jose Del Moral , BENTZIEN, Joerg Martin , BRUNETTE, Steven Richard , CHEN, Zhidong , COGAN, Derek , GAO, Donghong A. , HEIM-RIETHER, Alexander , HORAN, Joshua Courtney , KOWALSKI, Jennifer A. , LAWLOR, Michael David , LIU, Weimin , MCKIBBEN, Bryan , MILLER, Craig Andrew , MOSS, Neil , TSCHANTZ, Matt Aaron , XIONG, Zhaoming , YU, Hui , YU, Yang
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P29/00
CPC分类号： C07D487/04
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2.发明公开DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES 有权衍生物6,7-二氢-5H-咪唑并[1,2-A] - 咪唑烷-3-羧酸钠
公开(公告)号：EP2225238A1
公开(公告)日：2010-09-08
申请号：EP08853791.5
申请日：2008-11-20
发明人： LEMIEUX, Rene M. , BARBOSA, Antonio Jose Del Moral , BENTZIEN, Joerg Martin , BRUNETTE, Steven Richard , CHEN, Zhidong , COGAN, Derek , GAO, Donghong A. , HEIM-RIETHER, Alexander , HORAN, Joshua Courtney , KOWALSKI, Jennifer A. , LAWLOR, Michael David , LIU, Weimin , MCKIBBEN, Bryan , MILLER, Craig Andrew , MOSS, Neil , TSCHANTZ, Matt Aaron , XIONG, Zhaoming , YU, Hui , YU, Yang
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P29/00
CPC分类号： C07D487/04
摘要： Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
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公开(公告)号：EP2882741B1
公开(公告)日：2018-10-24
申请号：EP13752756.0
申请日：2013-08-08
发明人： BENTZIEN, Joerg Martin , BERRY, Angela Kay , BOSANAC, Todd , BURKE, Michael, Jason , DISALVO, Darren, Todd , HORAN, Joshua, Courtney , LIANG, Shuang , MAO, Can , MAO, Wang , SHEN, Yue , SOLEYMANZADEH, Fariba , ZINDELL, Renee, M.
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D231/38 , C07D401/04 , C07D401/06 , C07D403/02 , C07D403/06 , C07D417/02 , C07D417/04 , C07D417/06 , C07D277/56 , C07D403/04 , A61P19/00 , A61P11/00
CPC分类号： C07D417/08 , C07D231/14 , C07D231/38 , C07D231/40 , C07D277/56 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D405/14 , C07D413/14 , C07D417/02 , C07D417/04 , C07D417/06
摘要： The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
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4.发明公开HETEROAROMATIC COMPOUNDS AS BRUTON'S TYROSINE KINASE (BTK) INHIBITORS 审中-公开杂芳族化合物ALS布鲁顿酪氨酸激酶（BTK）抑制剂
公开(公告)号：EP2882741A1
公开(公告)日：2015-06-17
申请号：EP13752756.0
申请日：2013-08-08
发明人： BENTZIEN, Joerg Martin , BERRY, Angela Kay , BOSANAC, Todd , BURKE, Michael, Jason , DISALVO, Darren, Todd , HORAN, Joshua, Courtney , LIANG, Shuang , MAO, Can , MAO, Wang , SHEN, Yue , SOLEYMANZADEH, Fariba , ZINDELL, Renee, M.
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D231/38 , C07D401/04 , C07D401/06 , C07D403/02 , C07D403/06 , C07D417/02 , C07D417/04 , C07D417/06 , C07D277/56 , C07D403/04 , A61P19/00 , A61P11/00
CPC分类号： C07D417/08 , C07D231/14 , C07D231/38 , C07D231/40 , C07D277/56 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D405/14 , C07D413/14 , C07D417/02 , C07D417/04 , C07D417/06
摘要： wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
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