-
1.发明公开DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES 有权衍生物6,7-二氢-5H-咪唑并[1,2-A] - 咪唑烷-3-羧酸钠
公开(公告)号：EP2225238A1
公开(公告)日：2010-09-08
申请号：EP08853791.5
申请日：2008-11-20
发明人： LEMIEUX, Rene M. , BARBOSA, Antonio Jose Del Moral , BENTZIEN, Joerg Martin , BRUNETTE, Steven Richard , CHEN, Zhidong , COGAN, Derek , GAO, Donghong A. , HEIM-RIETHER, Alexander , HORAN, Joshua Courtney , KOWALSKI, Jennifer A. , LAWLOR, Michael David , LIU, Weimin , MCKIBBEN, Bryan , MILLER, Craig Andrew , MOSS, Neil , TSCHANTZ, Matt Aaron , XIONG, Zhaoming , YU, Hui , YU, Yang
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P29/00
CPC分类号： C07D487/04
摘要： Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
-
2.发明授权DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES 有权[ - - 1,2-a]咪唑-3-羧酸酰胺的6,7-二氢-5H-咪唑并衍生物
公开(公告)号：EP2225238B1
公开(公告)日：2014-09-03
申请号：EP08853791.5
申请日：2008-11-20
发明人： LEMIEUX, Rene M. , BARBOSA, Antonio Jose Del Moral , BENTZIEN, Joerg Martin , BRUNETTE, Steven Richard , CHEN, Zhidong , COGAN, Derek , GAO, Donghong A. , HEIM-RIETHER, Alexander , HORAN, Joshua Courtney , KOWALSKI, Jennifer A. , LAWLOR, Michael David , LIU, Weimin , MCKIBBEN, Bryan , MILLER, Craig Andrew , MOSS, Neil , TSCHANTZ, Matt Aaron , XIONG, Zhaoming , YU, Hui , YU, Yang
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P29/00
CPC分类号： C07D487/04
-
公开(公告)号：EP1866286B1
公开(公告)日：2009-05-27
申请号：EP06748747.0
申请日：2006-03-27
IPC分类号： C07D213/74 , C07D401/12 , C07D213/85 , A61K31/44 , A61K31/4523 , A61P3/00 , A61P37/00 , A61P29/00
CPC分类号： C07D213/74 , C07D213/82 , C07D213/85 , C07D401/12
摘要： Disclosed are novel compounds of formula (I) wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
-
公开(公告)号：EP1866286A1
公开(公告)日：2007-12-19
申请号：EP06748747.0
申请日：2006-03-27
IPC分类号： C07D213/74 , C07D401/12 , C07D213/85 , A61K31/44 , A61K31/4523 , A61P3/00 , A61P37/00 , A61P29/00
CPC分类号： C07D213/74 , C07D213/82 , C07D213/85 , C07D401/12
摘要： Disclosed are novel compounds of formula (I) wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
-
公开(公告)号：EP3390390A2
公开(公告)日：2018-10-24
申请号：EP16867378.8
申请日：2016-12-15
发明人： BOSANAC, Todd , BENTZIEN, Joerg , BURKE, Michael Jason , FRYER, Ryan Michael , LARSON, Eric Thomas , MAO, Wang , MCKIBBEN, Bryan Patrick , SHEN, Yue , SOLEYMANZADEH, Fariba , TSCHANTZ, Matt Aaron
IPC分类号： C07D401/14 , C07D403/14 , A61K31/4155 , A61K31/4439 , A61P37/06
CPC分类号： C07D403/14 , C07D401/14
摘要： wherein the groups R1, Cy and Y are defined herein, which are suitable for the treatment of diseases related to BTK, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.
-
6.发明公开DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES 有权6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-羧酸酰胺衍生物
公开(公告)号：EP2445914A1
公开(公告)日：2012-05-02
申请号：EP10721253.2
申请日：2010-05-28
IPC分类号： C07D487/04 , A61K31/4188 , A61K31/4427 , A61P29/00
CPC分类号： C07D487/04
摘要： Derivatives of 6,7-dihydro-5H-imidazo[1,2-
a ]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.024 秒)
