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公开(公告)号：EP2630144A1
公开(公告)日：2013-08-28
申请号：EP11776653.5
申请日：2011-10-17
发明人： KIRRANE, JR., Thomas Martin , MARSHALL, Daniel Richard , SIBLEY, Robert , SNOW, Roger John , SOLEYMANZADEH, Fariba , SORCEK, Ronald John
IPC分类号： C07D417/12 , C07D513/04 , A61K31/167 , A61P9/10
CPC分类号： C07D417/12 , C07D277/60 , C07D417/14
摘要： The present invention relates to compounds of formula I and pharmaceutically acceptable salts thereof, wherein R
1 , R
2 , R
3 and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3和X如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和用于这些方法的中间体。
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公开(公告)号：EP2766360B1
公开(公告)日：2017-07-12
申请号：EP12762428.6
申请日：2012-08-09
发明人： BERRY, Angela , BOSANAC, Todd , GINN, John David , HOPKINS, Tamara Denise , SCHLYER, Sabine , SOLEYMANZADEH, Fariba , WESTBROOK, John , YU, Maolin , ZHANG, Zhonghua
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61P25/00
CPC分类号： C07D417/14 , C07D417/04 , C07D417/12
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3.发明公开HETEROAROMATIC COMPOUNDS AS BRUTON'S TYROSINE KINASE (BTK) INHIBITORS 审中-公开杂芳族化合物ALS布鲁顿酪氨酸激酶（BTK）抑制剂
公开(公告)号：EP2882741A1
公开(公告)日：2015-06-17
申请号：EP13752756.0
申请日：2013-08-08
发明人： BENTZIEN, Joerg Martin , BERRY, Angela Kay , BOSANAC, Todd , BURKE, Michael, Jason , DISALVO, Darren, Todd , HORAN, Joshua, Courtney , LIANG, Shuang , MAO, Can , MAO, Wang , SHEN, Yue , SOLEYMANZADEH, Fariba , ZINDELL, Renee, M.
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D231/38 , C07D401/04 , C07D401/06 , C07D403/02 , C07D403/06 , C07D417/02 , C07D417/04 , C07D417/06 , C07D277/56 , C07D403/04 , A61P19/00 , A61P11/00
CPC分类号： C07D417/08 , C07D231/14 , C07D231/38 , C07D231/40 , C07D277/56 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D405/14 , C07D413/14 , C07D417/02 , C07D417/04 , C07D417/06
摘要： wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
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公开(公告)号：EP3390390A2
公开(公告)日：2018-10-24
申请号：EP16867378.8
申请日：2016-12-15
发明人： BOSANAC, Todd , BENTZIEN, Joerg , BURKE, Michael Jason , FRYER, Ryan Michael , LARSON, Eric Thomas , MAO, Wang , MCKIBBEN, Bryan Patrick , SHEN, Yue , SOLEYMANZADEH, Fariba , TSCHANTZ, Matt Aaron
IPC分类号： C07D401/14 , C07D403/14 , A61K31/4155 , A61K31/4439 , A61P37/06
CPC分类号： C07D403/14 , C07D401/14
摘要： wherein the groups R1, Cy and Y are defined herein, which are suitable for the treatment of diseases related to BTK, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.
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5.发明授权N-CYCLYL-3-(CYCLYLCARBONYLAMINOMETHYL)BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS 有权的N-环基-3-（CYCLYLCARBONYLAMINOMETHYL）苯甲酰胺衍生物作为Rho激酶抑制剂的
公开(公告)号：EP2590950B1
公开(公告)日：2014-10-15
申请号：EP11738871.0
申请日：2011-06-30
发明人： COOK, Brian Nicholas , KOWALSKI, Jennifer A. , LI, Xiang , MARSHALL, Daniel Richard , SCHLYER, Sabine , SIBLEY, Robert , SMITH-KEENAN, Lana Louise , SOLEYMANZADEH, Fariba , SORCEK, Ronald John , YOUNG, Erick Richard Roush , ZHANG, Yunlong
IPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00 , A61K31/472 , A61P9/00
CPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
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公开(公告)号：EP2509980A1
公开(公告)日：2012-10-17
申请号：EP10787970.2
申请日：2010-11-30
发明人： BOYER, Stephen, James , GAO, Donghong, Amy , GUO, Xin , KIRRANE, Thomas, Martin, Jr. , SARKO, Christopher, Ronald , SNOW, Roger,John , SOLEYMANZADEH, Fariba , ZHANG, Yunlong
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/551 , A61P9/00 , A61P29/00
CPC分类号： C07D487/04 , C07D487/20 , C07D491/20
摘要： Disclosed are novel compounds which inhibit RSK, methods of making such compounds and pharmaceutical compositions comprising such compounds. Also disclosed are methods of treating RSK2 regulated disorders using compounds of the invention.
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7.发明公开SUBSTITUTED PYRIDINEAMIDE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS 审中-公开取代的吡啶酰胺类化合物的可溶性环氧化物水解酶抑制剂的
公开(公告)号：EP1987004A2
公开(公告)日：2008-11-05
申请号：EP07757015.8
申请日：2007-02-15
发明人： ELDRUP, Anne, Bettina , FARROW, Neil, Alexander , KOWALSKI, Jennifer, A. , DELOMBAERT, Stephane , MUGGE, Ingo, Andreas , SOLEYMANZADEH, Fariba , SWINAMER, Alan, David , TAYLOR, Steven, John
IPC分类号： C07D213/81 , C07D213/82 , C07D239/34 , A61K31/44 , A61K31/505 , A61P9/00
CPC分类号： C07D213/81 , C07D213/82 , C07D239/34
摘要： Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.
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公开(公告)号：EP3402789B1
公开(公告)日：2020-03-18
申请号：EP17701778.7
申请日：2017-01-12
发明人： BOSANAC, Todd , BENTZIEN, Joerg , BURKE, Michael Jason , DISALVO, Darren Todd , MAO, Wang , SOLEYMANZADEH, Fariba , WESTBROOK, John , XIONG, Zhaoming
IPC分类号： C07D401/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D471/04 , A61K31/4725 , A61K31/506 , A61P19/00 , A61P37/00
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公开(公告)号：EP2630144B1
公开(公告)日：2016-09-07
申请号：EP11776653.5
申请日：2011-10-17
发明人： KIRRANE, JR., Thomas Martin , MARSHALL, Daniel Richard , SIBLEY, Robert , SNOW, Roger John , SOLEYMANZADEH, Fariba , SORCEK, Ronald John
IPC分类号： C07D417/12 , C07D513/04 , A61K31/167 , A61P9/10
CPC分类号： C07D417/12 , C07D277/60 , C07D417/14
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公开(公告)号：EP2766360A1
公开(公告)日：2014-08-20
申请号：EP12762428.6
申请日：2012-08-09
发明人： BERRY, Angela , BOSANAC, Todd , GINN, John David , HOPKINS, Tamara Denise , SCHLYER, Sabine , SOLEYMANZADEH, Fariba , WESTBROOK, John , YU, Maolin , ZHANG, Zhonghua
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61P25/00
CPC分类号： C07D417/14 , C07D417/04 , C07D417/12
摘要： The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R
1 - R
5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 5和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和用于这些方法的中间体。
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