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1.发明公开GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开糖皮质激素模拟物，其制备方法，药物组合物及其用途
公开(公告)号：EP2102170A2
公开(公告)日：2009-09-23
申请号：EP07864855.7
申请日：2007-11-29
IPC分类号： C07D231/56 , C07D401/14 , C07D403/04 , C07D403/06 , C07D409/06 , C07D417/06 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00 , A61K31/437 , A61K31/416 , A61P5/44 , A61P5/46
CPC分类号： C07D417/06 , C07D231/56 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D407/14 , C07D409/06 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00
摘要： Compounds of Formula (IA), and Formula (IB), wherein R1, R2, R3, A, B, C, D, E, G, X, Y, and Z are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 其中R 1，R 2，R 3，A，B，C，D，E，G，X，Y和Z如本文所定义的式（IA）和式（IB）化合物或其互变异构体，前药，溶剂化物 或其盐; 含有这些化合物的药物组合物以及调节糖皮质激素受体功能的方法以及使用这些化合物治疗患者的糖皮质激素受体功能介导的疾病状态或病症或以炎症，变应原或增殖过程为特征的方法。
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公开(公告)号：EP3390390A2
公开(公告)日：2018-10-24
申请号：EP16867378.8
申请日：2016-12-15
发明人： BOSANAC, Todd , BENTZIEN, Joerg , BURKE, Michael Jason , FRYER, Ryan Michael , LARSON, Eric Thomas , MAO, Wang , MCKIBBEN, Bryan Patrick , SHEN, Yue , SOLEYMANZADEH, Fariba , TSCHANTZ, Matt Aaron
IPC分类号： C07D401/14 , C07D403/14 , A61K31/4155 , A61K31/4439 , A61P37/06
CPC分类号： C07D403/14 , C07D401/14
摘要： wherein the groups R1, Cy and Y are defined herein, which are suitable for the treatment of diseases related to BTK, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.
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公开(公告)号：EP3402789B1
公开(公告)日：2020-03-18
申请号：EP17701778.7
申请日：2017-01-12
发明人： BOSANAC, Todd , BENTZIEN, Joerg , BURKE, Michael Jason , DISALVO, Darren Todd , MAO, Wang , SOLEYMANZADEH, Fariba , WESTBROOK, John , XIONG, Zhaoming
IPC分类号： C07D401/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D471/04 , A61K31/4725 , A61K31/506 , A61P19/00 , A61P37/00
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公开(公告)号：EP3402789A1
公开(公告)日：2018-11-21
申请号：EP17701778.7
申请日：2017-01-12
发明人： BOSANAC, Todd , BENTZIEN, Joerg , BURKE, Michael Jason , DISALVO, Darren Todd , MAO, Wang , SOLEYMANZADEH, Fariba , WESTBROOK, John , XIONG, Zhaoming
IPC分类号： C07D401/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D471/04 , A61K31/4725 , A61K31/506 , A61P19/00 , A61P37/00
摘要： The present invention encompasses compounds of the formula (I) wherein the groups R1, R2, R3, R4 and R5 are defined herein, which are suitable for the treatment of diseases related to Bruton's tyrosine kinase (BTK), and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.
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