公开(公告)号：EP3512837B1

公开(公告)日：2020-07-22

申请号：EP17768582.3

申请日：2017-09-06

申请人： Boehringer Ingelheim International GmbH

发明人： CUI, Jianwen ,  GAO, Donghong Amy ,  LIU, Pingrong ,  MCKIBBEN, Bryan Patrick ,  MILLER, Craig Andrew ,  RAZAVI, Hossein ,  RUPPEL, Sabine ,  PADYANA, Anil K. ,  SPENCER, Elizabeth

IPC分类号： C07D401/04 ,  C07D403/04 ,  A61K31/4439 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06

公开(公告)号：EP3512837A1

公开(公告)日：2019-07-24

申请号：EP17768582.3

申请日：2017-09-06

申请人： Boehringer Ingelheim International GmbH ,  Spencer, Elizabeth

发明人： CUI, Jianwen ,  GAO, Donghong Amy ,  LIU, Pingrong ,  MCKIBBEN, Bryan Patrick ,  MILLER, Craig Andrew ,  RAZAVI, Hossein ,  RUPPEL, Sabine ,  PADYANA, Anil K. ,  SPENCER, Elizabeth

IPC分类号： C07D401/04 ,  C07D403/04 ,  A61K31/4439 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06

摘要： or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes

公开(公告)号：EP3390390A2

公开(公告)日：2018-10-24

申请号：EP16867378.8

申请日：2016-12-15

申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH

发明人： BOSANAC, Todd ,  BENTZIEN, Joerg ,  BURKE, Michael Jason ,  FRYER, Ryan Michael ,  LARSON, Eric Thomas ,  MAO, Wang ,  MCKIBBEN, Bryan Patrick ,  SHEN, Yue ,  SOLEYMANZADEH, Fariba ,  TSCHANTZ, Matt Aaron

IPC分类号： C07D401/14 ,  C07D403/14 ,  A61K31/4155 ,  A61K31/4439 ,  A61P37/06

CPC分类号： C07D403/14 ,  C07D401/14

摘要： wherein the groups R1, Cy and Y are defined herein, which are suitable for the treatment of diseases related to BTK, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.