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1.发明授权COMBINATIONS FOR THE TREATMENT OF DISEASES INVOLVING CELL PROLIFERATION, MIGRATION OR APOPTOSIS OF MYELOMA CELLS, OR ANGIOGENESIS 有权复方制剂用于疾病的，增殖，迁移的治疗，骨髓瘤细胞的凋亡EMBRACE或血管生成
公开(公告)号：EP1622619B1
公开(公告)日：2013-09-04
申请号：EP04729366.7
申请日：2004-04-24
发明人： HILBERG, Frank , SOLCA, Flavio , STEFANIC, Martin Friedrich , BAUM, Anke , MUNZERT, Gerd , VAN MEEL, Jacobus, C.A.
IPC分类号： A61K31/496 , A61K31/517 , A61P35/00 , A61K31/404
CPC分类号： A61K31/496 , A61K31/404 , A61K31/517 , A61K31/553 , A61K31/56 , A61K45/06 , A61K2300/00
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公开(公告)号：EP2985025A1
公开(公告)日：2016-02-17
申请号：EP15179438.5
申请日：2009-06-04
IPC分类号： A61K31/496 , A61K31/519 , A61P35/00 , A61P3/10 , A61P17/06 , A61P19/02 , A61P25/02 , A61P9/00 , A61P11/06 , A61P27/02 , A61P1/16 , A61P43/00 , A61K9/48
CPC分类号： A61K31/519 , A61K9/4858 , A61K31/496 , A61N5/10 , A61K2300/00
摘要： The present invention relates to a pharmaceutical combination which may be useful for the treatment of diseases which involve cell proliferation, which involve migration or apoptosis of myeloma cells, which involve angiogenesis or which involve fibrosis. The invention also relates to a method for the treatment of said diseases, comprising simultaneous, separate or sequential administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.
摘要翻译： 本发明涉及可用于治疗涉及涉及血管生成或涉及纤维化的骨髓瘤细胞的迁移或凋亡的涉及细胞增殖的疾病的药物组合。 本发明还涉及一种用于治疗所述疾病的方法，包括以提供添加剂和协同效应的比例同时，分别或连续施用有效量的特定活性化合物和/或与放射治疗共同治疗，以及 将这些特定化合物和/或放射疗法的组合使用用于制造相应的药物组合制剂。
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公开(公告)号：EP2293795B1
公开(公告)日：2015-08-12
申请号：EP09757599.7
申请日：2009-06-04
IPC分类号： A61K9/48 , A61K31/496 , A61K31/519 , A61P35/00 , A61P3/10 , A61P17/06 , A61P19/02 , A61P25/02 , A61P9/00 , A61P11/06 , A61P27/02 , A61P1/16 , A61P43/00
CPC分类号： A61K31/519 , A61K9/4858 , A61K31/496 , A61N5/10 , A61K2300/00
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公开(公告)号：EP2985025B1
公开(公告)日：2018-01-17
申请号：EP15179438.5
申请日：2009-06-04
IPC分类号： A61K31/496 , A61K31/519 , A61P35/00 , A61P3/10 , A61P17/06 , A61P19/02 , A61P25/02 , A61P9/00 , A61P11/06 , A61P27/02 , A61P1/16 , A61P43/00 , A61K9/48
CPC分类号： A61K31/519 , A61K9/4858 , A61K31/496 , A61N5/10 , A61K2300/00
摘要： The present invention relates to a pharmaceutical combination which may be useful for the treatment of diseases which involve cell proliferation, which involve migration or apoptosis of myeloma cells, which involve angiogenesis or which involve fibrosis. The invention also relates to a method for the treatment of said diseases, comprising simultaneous, separate or sequential administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.
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公开(公告)号：EP2293795A1
公开(公告)日：2011-03-16
申请号：EP09757599.7
申请日：2009-06-04
IPC分类号： A61K31/496 , A61K31/519 , A61P35/00 , A61P3/10 , A61P17/06 , A61P19/02 , A61P25/02 , A61P9/00 , A61P11/06 , A61P27/02 , A61P1/16 , A61P43/00
CPC分类号： A61K31/519 , A61K9/4858 , A61K31/496 , A61N5/10 , A61K2300/00
摘要： The present invention relates to a pharmaceutical combination which may be useful for the treatment of diseases which involve cell proliferation, which involve migration or apoptosis of myeloma cells, which involve angiogenesis or which involve fibrosis. The invention also relates to a method for the treatment of said diseases, comprising simultaneous, separate or sequential administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.
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6.发明公开COMBINATIONS FOR THE TREATMENT OF DISEASES INVOLVING CELL PROLIFERATION, MIGRATION OR APOPTOSIS OF MYELOMA CELLS, OR ANGIOGENESIS 有权复方制剂用于疾病的，增殖，迁移的治疗，骨髓瘤细胞的凋亡EMBRACE或血管生成
公开(公告)号：EP1622619A2
公开(公告)日：2006-02-08
申请号：EP04729366.7
申请日：2004-04-24
发明人： HILBERG, Frank , SOLCA, Flavio , STEFANIC, Martin Friedrich , BAUM, Anke , MUNZERT, Gerd , VAN MEEL, Jacobus, C.A.
IPC分类号： A61K31/496 , A61K31/517 , A61P35/00 , A61K31/404
CPC分类号： A61K31/496 , A61K31/404 , A61K31/517 , A61K31/553 , A61K31/56 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said deseases, coomprising co-administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.
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