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公开(公告)号：EP3630822A1
公开(公告)日：2020-04-08
申请号：EP18727819.7
申请日：2018-06-01
IPC分类号： C07K16/22 , C07K16/18 , A61K39/395 , C07K16/28 , A61K31/502 , A61P35/00 , C07K16/46
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2.发明授权COMBINATIONS FOR THE TREATMENT OF DISEASES INVOLVING CELL PROLIFERATION, MIGRATION OR APOPTOSIS OF MYELOMA CELLS, OR ANGIOGENESIS 有权复方制剂用于疾病的，增殖，迁移的治疗，骨髓瘤细胞的凋亡EMBRACE或血管生成
公开(公告)号：EP1622619B1
公开(公告)日：2013-09-04
申请号：EP04729366.7
申请日：2004-04-24
发明人： HILBERG, Frank , SOLCA, Flavio , STEFANIC, Martin Friedrich , BAUM, Anke , MUNZERT, Gerd , VAN MEEL, Jacobus, C.A.
IPC分类号： A61K31/496 , A61K31/517 , A61P35/00 , A61K31/404
CPC分类号： A61K31/496 , A61K31/404 , A61K31/517 , A61K31/553 , A61K31/56 , A61K45/06 , A61K2300/00
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公开(公告)号：EP2985025B1
公开(公告)日：2018-01-17
申请号：EP15179438.5
申请日：2009-06-04
IPC分类号： A61K31/496 , A61K31/519 , A61P35/00 , A61P3/10 , A61P17/06 , A61P19/02 , A61P25/02 , A61P9/00 , A61P11/06 , A61P27/02 , A61P1/16 , A61P43/00 , A61K9/48
CPC分类号： A61K31/519 , A61K9/4858 , A61K31/496 , A61N5/10 , A61K2300/00
摘要： The present invention relates to a pharmaceutical combination which may be useful for the treatment of diseases which involve cell proliferation, which involve migration or apoptosis of myeloma cells, which involve angiogenesis or which involve fibrosis. The invention also relates to a method for the treatment of said diseases, comprising simultaneous, separate or sequential administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.
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公开(公告)号：EP2293795A1
公开(公告)日：2011-03-16
申请号：EP09757599.7
申请日：2009-06-04
IPC分类号： A61K31/496 , A61K31/519 , A61P35/00 , A61P3/10 , A61P17/06 , A61P19/02 , A61P25/02 , A61P9/00 , A61P11/06 , A61P27/02 , A61P1/16 , A61P43/00
CPC分类号： A61K31/519 , A61K9/4858 , A61K31/496 , A61N5/10 , A61K2300/00
摘要： The present invention relates to a pharmaceutical combination which may be useful for the treatment of diseases which involve cell proliferation, which involve migration or apoptosis of myeloma cells, which involve angiogenesis or which involve fibrosis. The invention also relates to a method for the treatment of said diseases, comprising simultaneous, separate or sequential administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.
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5.发明公开COMBINATIONS FOR THE TREATMENT OF DISEASES INVOLVING CELL PROLIFERATION, MIGRATION OR APOPTOSIS OF MYELOMA CELLS, OR ANGIOGENESIS 有权复方制剂用于疾病的，增殖，迁移的治疗，骨髓瘤细胞的凋亡EMBRACE或血管生成
公开(公告)号：EP1622619A2
公开(公告)日：2006-02-08
申请号：EP04729366.7
申请日：2004-04-24
发明人： HILBERG, Frank , SOLCA, Flavio , STEFANIC, Martin Friedrich , BAUM, Anke , MUNZERT, Gerd , VAN MEEL, Jacobus, C.A.
IPC分类号： A61K31/496 , A61K31/517 , A61P35/00 , A61K31/404
CPC分类号： A61K31/496 , A61K31/404 , A61K31/517 , A61K31/553 , A61K31/56 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said deseases, coomprising co-administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.
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6.发明公开
公开(公告)号：EP2429520A1
公开(公告)日：2012-03-21
申请号：EP10721441.3
申请日：2010-05-11
IPC分类号： A61K31/405 , A61K31/4439 , A61P35/00
CPC分类号： A61K31/496 , A61K31/405 , A61K31/4439 , A61K31/517 , A61K2300/00
摘要： The invention relates to new methods for the treatment of oncological and fϊbrotic disease comprising the combined administration of an inhibitor of vascular endothelial growth factor receptors (VEGFRs) in conjunction with a thrombin inhibitor.
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公开(公告)号：EP2387401A1
公开(公告)日：2011-11-23
申请号：EP10700174.5
申请日：2010-01-13
发明人： LARSEN, Annette , BAUM, Anke , HILBERG, Frank , SOLCA, Flavio
IPC分类号： A61K31/496 , A61K31/517 , A61P35/00
CPC分类号： A61K31/496 , A61K31/517 , A61K2300/00
摘要： The present invention relates to a method of treating patients suffering from colorectal cancer characterized by coadministration of BIBF 1120 and BIBW 2992, wherein in said method BIBF 1120 is administered according to a continuous daily regimen and BIBW 2992 is administered according to a weekly alternating on-off regimen, pharmaceutical compositions and kits suitable for this method as well as their preparation.
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公开(公告)号：EP1799690B1
公开(公告)日：2008-04-16
申请号：EP05792037.3
申请日：2005-10-05
发明人： BETZEMEIER, Bodo , BRANDL, Trixi , BREITFELDER, Steffen , BRUECKNER, Ralph , GERSTBERGER, Thomas , GMACHL, Michael , GRAUERT, Matthias , HILBERG, Frank , HOENKE, Christoph , HOFFMANN, Matthias , IMPAGNATIELLO, Maria , KESSLER, Dirk , KLEIN, Christian , KRIST, Bernd , MAIER, Udo , MCCONNELL, Darryl , REITHER, Charlotte , SCHEUERER,Stefan , SCHOOP, Andreas , SCHWEIFER, Norbert , SIMON, Oliver , STEEGMAIER, Martin , STEURER, Steffen , WAIZENEGGER, Irene , WEYER-CZERNILOFSKY, Ulrike , ZOEPHEL, Andreas
IPC分类号： C07D513/04 , C07D417/06 , C07D277/82 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04 , C07D277/82 , C07D277/84 , C07D417/06
摘要： The invention relates to the compounds of general formula (1), wherein R1 to R3 are defined as in claim 1, which are suitable for use in the treatment of diseases that are characterized by excessive or abnormal cell proliferation. The invention also relates to the use of said compounds for producing a drug having the aforementioned properties.
摘要翻译： 本发明涉及通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗以过度或异常细胞增殖为特征的疾病。 本发明还涉及所述化合物用于制备具有上述性质的药物的用途。
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公开(公告)号：EP1799690A1
公开(公告)日：2007-06-27
申请号：EP05792037.3
申请日：2005-10-05
发明人： BETZEMEIER, Bodo , BRANDL, Trixi , BREITFELDER, Steffen , BRUECKNER, Ralph , GERSTBERGER, Thomas , GMACHL, Michael , GRAUERT, Matthias , HILBERG, Frank , HOENKE, Christoph , HOFFMANN, Matthias , IMPAGNATIELLO, Maria , KESSLER, Dirk , KLEIN, Christian , KRIST, Bernd , MAIER, Udo , MCCONNELL, Darryl , REITHER, Charlotte , SCHEUERER,Stefan , SCHOOP, Andreas , SCHWEIFER, Norbert , SIMON, Oliver , STEEGMAIER, Martin , STEURER, Steffen , WAIZENEGGER, Irene , WEYER-CZERNILOFSKY, Ulrike , ZOEPHEL, Andreas
IPC分类号： C07D513/04 , C07D417/06 , C07D277/82 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04 , C07D277/82 , C07D277/84 , C07D417/06
摘要： The invention relates to the compounds of general formula (1), wherein R1 to R3 are defined as in claim 1, which are suitable for use in the treatment of diseases that are characterized by excessive or abnormal cell proliferation. The invention also relates to the use of said compounds for producing a drug having the aforementioned properties.
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10.发明公开PHARMACEUTICAL COMBINATION OF NINTEDANIB AND CAPECITABINE FOR THE TREATMENT OF COLORECTAL CANCER 审中-公开恩丹西治与卡培他滨联合治疗结直肠癌的药物组合
公开(公告)号：EP3246029A1
公开(公告)日：2017-11-22
申请号：EP16170498.6
申请日：2016-05-19
发明人： HILBERG, Frank
IPC分类号： A61K31/496 , A61P35/00 , A61P35/04 , A61K31/513
CPC分类号： A61K31/496 , A61K31/513 , A61K2300/00
摘要： The compounds
• 3-Z-[1-(4-( N -((4-methyl-piperazin-1-yl)-methylcarbonyl)- N -methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone or a pharmaceutically acceptable salt thereof, and
• 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine or a pharmaceutically acceptable salt thereof,
for combined use in the treatment of colorectal cancer.摘要翻译： 化合物·3-Z- [1-（4-（N - （（4-甲基 - 哌嗪-1-基） - 甲基羰基）-N-甲基 - 氨基） - 苯胺基）-1-苯基 - 亚甲基] - 甲氧基羰基-2-二氢吲哚酮或其药学上可接受的盐和·5'-脱氧-5-氟-N - [（戊氧基）羰基] - 胞苷或其药学上可接受的盐，用于联合治疗结直肠癌 。
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