-
1.发明授权NEUE PYRAZINCARBOXAMIDDERIVATE, IHRE HERSTELLUNG UND IHRE VERWENDUNG IN ARZNEIMITTELN 失效新PYRAZINCARBOXAMIDDERIVATE，生产和它们在药物
公开(公告)号：EP0726899B1
公开(公告)日：2000-01-19
申请号：EP94931018.9
申请日：1994-10-31
IPC分类号： C07D403/12 , C07D487/04 , C07D471/04 , C07D401/12 , C07D241/34 , A61K31/495
CPC分类号： C07D403/12
-
2.发明授权
公开(公告)号：EP0802922B1
公开(公告)日：2001-09-26
申请号：EP95909796.5
申请日：1995-03-02
发明人： ESSER, Franz , SCHNORRENBERG, Gerd , DOLLINGER, Horst , JUNG, Birgit , BUERGER, Erich , SPECK, Georg
CPC分类号： C07D215/38 , A61K38/00 , C07D401/14 , C07D491/04 , C07K5/0202 , C07K5/06139 , C07K5/06165
摘要： The invention concerns novel amino acid derivatives of general formula (I) and their pharmaceutically acceptable salts, in which the R2 group is (II) and R1, A, G, Y, Z and m have the meanings given in the description, and their production and use. The novel compounds are valuable neurokinin (tachykinin) antagonists.
-
3.发明授权BENZOYLGUANIDINE, IHRE HERSTELLUNG UND IHRE VERWENDUNG IN ARZNEIMITTELN 失效Benzoylguanidines，生产和它们在药物
公开(公告)号：EP0733046B1
公开(公告)日：2001-06-27
申请号：EP94931019.7
申请日：1994-10-31
IPC分类号： C07D239/95 , C07D487/04 , C07D213/74 , C07D295/14 , C07D239/42 , C07D241/20 , C07D403/04 , A61K31/505
CPC分类号： C07D213/74 , C07D239/95 , C07D487/04
-
4.发明授权ARZNEIMITTELVORBEREITUNGEN ENTHALTEND EIN ENANTIOMER VON IPRATROPIUMBROMID MIT VERLÄNGERTER WIRKUNGSDAUER 失效DRUGS PREPARATIONS含异丙托溴铵的对映体延长的持续时间的影响
公开(公告)号：EP0843676B1
公开(公告)日：2001-11-07
申请号：EP96927638.5
申请日：1996-07-31
发明人： BANHOLZER, Rolf , REICHL, Richard , DISSE, Bernd , SPECK, Georg
IPC分类号： C07D451/10 , A61K31/46
CPC分类号： C07D451/10
摘要： The invention concerns the use of the salts of the L-(-)-enantiomer of (endo, syn)-(-)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(methylethyl)-8-azoniabicyclo[3.2.1] octane as active substances for medicaments administered by inhalation for treatment of the respiratory tract. These salts are suitable for such treatment owing to their unexpectedly intense and prolonged effect.
-
5.发明公开NEUE ARYLGLYCINAMIDDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN 失效新arylglycinamide衍生物，PROCESS它们的制造和药物组合物含
公开(公告)号：EP0885204A1
公开(公告)日：1998-12-23
申请号：EP97906150.0
申请日：1997-03-03
发明人： ESSER, Franz , SCHNORRENBERG, Gerd , SCHROMM, Kurt , DOLLINGER, Horst , JUNG, Birgit , SPECK, Georg
IPC分类号： A61K31 , A61P1 , A61P11 , A61P17 , A61P19 , A61P25 , A61P27 , A61P29 , A61P37 , A61P43 , C07D211 , C07D213 , C07D221 , C07D239 , C07D241 , C07D243 , C07D295 , C07D317
CPC分类号： C07D221/14 , C07D211/46 , C07D211/58 , C07D213/74 , C07D239/42 , C07D241/08 , C07D243/08 , C07D295/145 , C07D295/185 , C07D295/30 , C07D317/60
摘要： The invention relates to novel aryl glycinamide derivatives of formula (I) and their pharmaceutically acceptable salts, in which R?1 and R2¿ together with the N to which they are bound form a ring of one of the formulae (a), (b), (c) or (d), in which R?3, R4, R5, Ar, R6, R7, R8, R9, R10, R11¿, r, s and t have the meanings indicated in the description. Also disclosed are the production and use of these compounds. The novel compounds are valuable neurokinin (tachykinin) antagonists.
-
6.发明公开PIPERIDINSUBSTITUIERTE ARYLGLYCINAMIDE ALS NEUROKININANTAGONISTEN, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN 审中-公开PIPERIDINSUBSTITUIERTE ARYLGLYCINAMIDE ALS NEUROKININANTAGONISTEN，VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN
公开(公告)号：EP1328516A1
公开(公告)日：2003-07-23
申请号：EP01987744.8
申请日：2001-10-16
发明人： DOLLINGER, Horst , ESSER, Franz , JUNG, Birgit , SCHROMM, Kurt , SPECK, Georg
IPC分类号： C07D211/58 , A61K31/4468 , A61P9/02
CPC分类号： C07D405/06 , C07D211/58
摘要： The invention relates to novel compounds of formula (I) or the pharmaceutically acceptable salts thereof, wherein R1 represents 3-hydroxypropyl, 1,3-dihydroxyprop-2-yl or C¿3?-C6 cycloalkylmethyl, and R?2, R3, R4¿ and Ar have the designations cited in the description. The invention also relates to the production and use of said compounds. The inventive novel compounds are valuable neurokinin (tachykinin) antagonists.
摘要翻译： 本发明涉及式（I）的新化合物或其药学上可接受的盐，其中R 1代表3-羟基丙基，1,3-二羟基丙-2-基或C 3 -C 6环烷基甲基，R 2，R 3， R4和Ar具有在说明书中引用的名称。 本发明还涉及所述化合物的生产和使用。 本发明的新型化合物是有价值的神经激肽（速激肽）拮抗剂。
-
7.发明公开ARYLSULFONAMID-SUBSTITUIERTE BENZIMIDAZOLDERIVATE IHRE VERWENDUNG ALS TRYPTASE-INHIBITOREN 有权芳基磺酰胺取代的苯并咪唑衍生物及其作为类胰蛋白酶抑制剂
公开(公告)号：EP1220845A1
公开(公告)日：2002-07-10
申请号：EP00969275.7
申请日：2000-09-21
发明人： ANDERSKEWITZ, Ralf , BRAUN, Christine , BRIEM, Hans , DISSE, Bernd , HOENKE, Christoph , JENNEWEIN, Hans-Michael , SPECK, Georg
IPC分类号： C07D235/16 , C07D235/14 , C07D401/12 , A61K31/4184 , A61K31/4439 , A61P37/08 , A61P29/00
CPC分类号： C07D401/12 , C07D235/14 , C07D235/16
摘要： The invention relates to substituted benzimidazol derivatives of the general formula (I) wherein the radicals R?1, R2, R3 and R4¿ have the significance cited in the Claims and a method for the production of said derivatives and use of substituted benzimidazol derivatives as a medicament, in particular as a medicament with tryptase-inhibiting activity.
-
8.发明授权NEUE ARYLGLYCINAMIDDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN 失效新arylglycinamide衍生物，PROCESS它们的制造和药物组合物含
公开(公告)号：EP0885204B1
公开(公告)日：2002-06-12
申请号：EP97906150.4
申请日：1997-03-03
发明人： ESSER, Franz , SCHNORRENBERG, Gerd , SCHROMM, Kurt , DOLLINGER, Horst , JUNG, Birgit , SPECK, Georg
IPC分类号： C07D295/14 , C07D213/74 , C07D317/60
CPC分类号： C07D221/14 , C07D211/46 , C07D211/58 , C07D213/74 , C07D239/42 , C07D241/08 , C07D243/08 , C07D295/145 , C07D295/185 , C07D295/30 , C07D317/60
摘要： The invention relates to novel aryl glycinamide derivatives of formula (I) and their pharmaceutically acceptable salts, in which R?1 and R2¿ together with the N to which they are bound form a ring of one of the formulae (a), (b), (c) or (d), in which R?3, R4, R5, Ar, R6, R7, R8, R9, R10, R11¿, r, s and t have the meanings indicated in the description. Also disclosed are the production and use of these compounds. The novel compounds are valuable neurokinin (tachykinin) antagonists.
-
9.发明公开AMINOCARBONYL-SUBSTITUIERTE BENZIMIDAZOLDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权氨基羰基取代的苯并咪唑衍生物，其制造方法相同，并且它们作为药物
公开(公告)号：EP1210335A1
公开(公告)日：2002-06-05
申请号：EP00951526.3
申请日：2000-08-17
发明人： ANDERSKEWITZ, Ralf , BRAUN, Christine , BRIEM, Hans , DISSE, Bernd , HOENKE, Christoph , JENNEWEIN, Hans-Michael , SPECK, Georg
IPC分类号： C07D235/14 , C07D401/12 , C07D405/10 , C07D409/10 , C07D405/14 , C07D409/14 , C07D401/10 , C07D403/10 , C07D401/14
CPC分类号： C07D401/10 , A61K31/4184 , C07D235/14 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/10 , C07D409/14
摘要： The invention relates to aminocarbonyl-substituted benzimidazole derivatives of general formula (I), wherein the radicals R?1, R2, R3 and R4¿ can have the meanings given in the claims or in the description. The invention also relates to the prodrugs thereof, a method for producing the same and the use of benzimidazole derivatives as medicaments, especially medicaments with tryptase-inhibiting action.
-
10.发明公开ARYLSULFONAMID-SUBSTITUIERTE BENZIMIDAZOLDERIVATE UND IHRE VERWENDUNG ALS TRYPTASE-INHIBITOREN 有权芳基磺酰胺取代的苯并咪唑衍生物和它们作为类胰蛋白酶抑制剂使用
公开(公告)号：EP1220844A1
公开(公告)日：2002-07-10
申请号：EP00960686.4
申请日：2000-09-21
发明人： ANDERSKEWITZ, Ralf , BRAUN, Christine , BRIEM, Hans , DISSE, Bernd , HOENKE, Christoph , JENNEWEIN, Hans-Michael , SPECK, Georg
IPC分类号： C07D235/16 , C07D235/14 , C07D401/12 , C07D403/12 , C07D409/12 , C07D405/06 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/551 , A61P37/08 , A61P29/00
CPC分类号： C07D401/12 , C07D235/14 , C07D235/16 , C07D403/12 , C07D405/06 , C07D409/12
摘要： The invention relates to arylsulfonamide substituted benzimidazole derivatives of general formula (I), wherein the radicals R?1, R2, R3 and R4¿ are as cited in the claims and in the description, a method for the production thereof and the use of arylsulfonamide substituted benzimidazol derivatives as medicaments in particular as medicaments with tryptase-inhibiting activity.
-
-
-
-
-
-
-
-
-
搜索结果
27 条记录 (耗时 0.018 秒)
