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公开(公告)号：EP1332151A1
公开(公告)日：2003-08-06
申请号：EP01988722.3
申请日：2001-10-19
IPC分类号： C07H15/203 , A61K31/70 , A61P19/02 , A61P11/06
CPC分类号： C07H15/203
摘要： The invention relates to novel pyranoside derivatives of general formula (I), to methods for the production thereof, and to their use as medicaments.
摘要翻译： 本发明涉及通式（I）的新型吡喃糖苷衍生物，其制备方法及其作为药物的用途。
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2.发明公开AMINOCARBONYL-SUBSTITUIERTE BENZIMIDAZOLDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权氨基羰基取代的苯并咪唑衍生物，其制造方法相同，并且它们作为药物
公开(公告)号：EP1210335A1
公开(公告)日：2002-06-05
申请号：EP00951526.3
申请日：2000-08-17
发明人： ANDERSKEWITZ, Ralf , BRAUN, Christine , BRIEM, Hans , DISSE, Bernd , HOENKE, Christoph , JENNEWEIN, Hans-Michael , SPECK, Georg
IPC分类号： C07D235/14 , C07D401/12 , C07D405/10 , C07D409/10 , C07D405/14 , C07D409/14 , C07D401/10 , C07D403/10 , C07D401/14
CPC分类号： C07D401/10 , A61K31/4184 , C07D235/14 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/10 , C07D409/14
摘要： The invention relates to aminocarbonyl-substituted benzimidazole derivatives of general formula (I), wherein the radicals R?1, R2, R3 and R4¿ can have the meanings given in the claims or in the description. The invention also relates to the prodrugs thereof, a method for producing the same and the use of benzimidazole derivatives as medicaments, especially medicaments with tryptase-inhibiting action.
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3.发明公开
公开(公告)号：EP0929516A1
公开(公告)日：1999-07-21
申请号：EP97942007.0
申请日：1997-09-09
发明人： SCHROMM, Kurt , ANDERSKEWITZ, Ralf , RENTH, Ernst-Otto , BIRKE, Franz , JENNEWEIN, Hans, Michael , MEADE, Christopher, John, Montague
IPC分类号： A61K31 , B01J25 , A61P1 , A61P9 , A61P11 , A61P17 , A61P19 , A61P25 , C07B61 , C07C257 , C07C271 , C07D295 , C07D311 , C07D317
CPC分类号： C07D295/088 , C07C257/18 , C07C271/64
摘要： The current invention relates to new benzamidine derivatives, a process for the manufacture and the use thereof as medicaments. The new benzamidine derivatives have the general formula (1).
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4.发明授权
公开(公告)号：EP0770059B1
公开(公告)日：1999-04-07
申请号：EP95921824.9
申请日：1995-06-03
发明人： ANDERSKEWITZ, Ralf , SCHROMM, Kurt , RENTH, Ernst-Otto , BIRKE, Franz , FÜGNER, Armin , HEUER, Hubert , MEADE, Christopher
IPC分类号： C07C259/18 , C07C271/64 , C07C257/20 , C07C257/18 , A61K31/155
CPC分类号： C07C271/64
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5.发明公开ARYLSULFONAMID-SUBSTITUIERTE BENZIMIDAZOLDERIVATE UND IHRE VERWENDUNG ALS TRYPTASE-INHIBITOREN 有权芳基磺酰胺取代的苯并咪唑衍生物和它们作为类胰蛋白酶抑制剂使用
公开(公告)号：EP1220844A1
公开(公告)日：2002-07-10
申请号：EP00960686.4
申请日：2000-09-21
发明人： ANDERSKEWITZ, Ralf , BRAUN, Christine , BRIEM, Hans , DISSE, Bernd , HOENKE, Christoph , JENNEWEIN, Hans-Michael , SPECK, Georg
IPC分类号： C07D235/16 , C07D235/14 , C07D401/12 , C07D403/12 , C07D409/12 , C07D405/06 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/551 , A61P37/08 , A61P29/00
CPC分类号： C07D401/12 , C07D235/14 , C07D235/16 , C07D403/12 , C07D405/06 , C07D409/12
摘要： The invention relates to arylsulfonamide substituted benzimidazole derivatives of general formula (I), wherein the radicals R?1, R2, R3 and R4¿ are as cited in the claims and in the description, a method for the production thereof and the use of arylsulfonamide substituted benzimidazol derivatives as medicaments in particular as medicaments with tryptase-inhibiting activity.
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公开(公告)号：EP0931087B1
公开(公告)日：2002-04-03
申请号：EP97944867.7
申请日：1997-09-10
发明人： ANDERSKEWITZ, Ralf , SCHROMM, Kurt , RENTH, Ernst-Otto , BIRKE, Franz , JENNEWEIN, Hans, Michael , MEADE, Christopher, John, Montague , DING, Andreas
IPC分类号： C07H15/203 , C07H7/04 , A61K31/70
CPC分类号： C07H15/04
摘要： The present invention relates to novel pyranoside derivatives having general formula (I), process for the manufacture thereof and their use as medicaments.
摘要翻译： 本发明涉及具有通式（I）的新型吡喃糖苷衍生物，其制备方法及其作为药物的用途。
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7.发明授权NEUE AMIDINDERIVATE, IHRE HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL MIT LTB4-ANTAGONISTISCHER WIRKUNG 失效NEW脒衍生物，生产和使用与LTB4拮抗作用的药物
公开(公告)号：EP0625138B1
公开(公告)日：1999-06-02
申请号：EP93902195.2
申请日：1993-01-14
发明人： ANDERSKEWITZ, Ralf , SCHROMM, Kurt , RENTH, Ernst-Otto , HIMMELSBACH, Frank , BIRKE, Franz , FÜGNER, Armin
IPC分类号： C07C257/18 , A61K31/155 , C07D311/22 , C07D213/78 , A61K31/35 , A61K31/44
CPC分类号： C07D213/78 , C07C257/18 , C07C317/18 , C07C317/22 , C07C317/44 , C07C323/20 , C07C323/62 , C07D307/79 , C07D311/22
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公开(公告)号：EP1332128A1
公开(公告)日：2003-08-06
申请号：EP01978439.6
申请日：2001-10-19
IPC分类号： C07C305/24 , A61K31/095
CPC分类号： C07C305/24
摘要： The invention relates to novel sulfoxybenzamides of formula (I), wherein: Z0 represents a group selected among formulas -X1-(CH2)r-X2- and -CR?4R5-; A1 and A2¿, independent of one another, represent a 1,4-phenylene group or 1,3-phenylene group optionally substituted by one or more halogen atoms, C¿1?-C8 alkyl groups, C2-C8 alkenyl groups, C1-C8 alkyl halide groups or by C1-C8 alkoxy groups; Z?1 and Z2¿, independent of one another, represent a group of formula -X3-(CH2)8-X4- or a single bond; m and n, independent of one another, represent 0 or 1, and; radicals R?1, R2, R3, R4, R5, X1, X2, X3, X4¿, r and s have the meanings cited in the description. The invention also relates to a method for producing these novel compounds and to their use as medicaments, especially as leukotriene B¿4?(LTB4) antagonists.
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公开(公告)号：EP1250318A2
公开(公告)日：2002-10-23
申请号：EP01942357.3
申请日：2001-01-11
发明人： BRANDENBURG, Jörg , SOYKA, Rainer , SCHMID, Rolf , ANDERSKEWITZ, Ralf , BAUER, Rolf , HAMM, Rainer , KRÖBER, Jutta
IPC分类号： C07C269/00 , C07C271/12 , C07C255/54
CPC分类号： C07C271/00 , C07C269/00 , C07C271/20 , C07C271/64
摘要： The invention relates to a method for producing compounds of formula (I) wherein the radicals R?1 and R2¿ have the meanings given in the description and in the claims, which can be used on a large scale.
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10.发明公开NEUER LTB4-ANTAGONIST, VERFAHREN ZU DESSEN HERSTELLUNG UND DESSEN VERWENDUNG ALS ARZNEIMITTEL 有权新LTB4拮抗剂，方法用于其及其作为药物
公开(公告)号：EP1222162A1
公开(公告)日：2002-07-17
申请号：EP00971328.0
申请日：2000-10-06
发明人： ANDERSKEWITZ, Ralf
IPC分类号： C07C257/18 , A61K31/155 , A61P11/06
CPC分类号： C07C257/18
摘要： The invention relates to a novel LTB4 antagonist, to a method for the production thereof and to its use as a medicament.
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