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公开(公告)号：EP1858576B1
公开(公告)日：2010-10-20
申请号：EP06720683.9
申请日：2006-02-14
IPC分类号： A61M25/00
CPC分类号： A61M25/0082 , A61M5/14526 , A61M5/14593 , A61M5/148 , A61M5/1483 , A61M25/0074 , A61M25/0084 , A61M2025/0091
摘要： A catheter having a drug delivery unit at the distal end thereof. The drug delivery unit includes an actuator capable of assuming an activated and an inactivated configuration. The drag delivery unit also includes a receptacle capable of accepting a therapeutic agent. The actuator and receptacle are in communication with each other such that the actuator transmits force to the receptacle and the receptacle accepts force from the actuator in an activated configuration of the actuator. Also provided is a method of delivering a therapeutic agent to a target site using the catheter of the present invention.
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2.发明授权MULTILUMEN CATHETER AND IMPLANTS FOR THE DELIVERY OF THERAPEUTIC AGENTS TO TISSUES 有权多腔导管以及管理治疗剂的组织植入物
公开(公告)号：EP1383551B1
公开(公告)日：2010-07-14
申请号：EP01270107.4
申请日：2001-11-07
发明人： PALASIS, Maria , BARRY, James, J. , ELLIS, Louis , HENDRICKSON, Gary, L. , HARRISON, Kent, D. , WANG, Lixiao
CPC分类号： A61L29/16 , A61L2300/258 , A61L2300/414 , A61L2300/416 , A61L2300/64 , A61M25/0084 , A61M37/0069 , A61M2025/0089
摘要： A catheter is provided for delivering implants including therapeutic agents to tissues. The catheter is advancable intra-luminally to place the implants. In one embodiment, the implants include a liquid carrier and therapeutic agent for infusion into the tissue. In another embodiment, a solid carrier includes the therapeutic agent. In yet another embodiment, the implant is formed in situ.
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公开(公告)号：EP2121106A2
公开(公告)日：2009-11-25
申请号：EP08713332.8
申请日：2008-01-30
CPC分类号： A61M31/002 , A61F2/24 , A61F2250/0067
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device (502) is provided comprising a body. The body may have a portion (518) thereof including therapeutic agent (516) and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.
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公开(公告)号：EP1838377A1
公开(公告)日：2007-10-03
申请号：EP06717287.4
申请日：2006-01-03
CPC分类号： A61M25/0068 , A61B2017/00247 , A61B2018/00392 , A61M25/0071 , A61M25/0074 , A61M25/0084 , A61M25/10 , A61M2025/0058 , A61M2025/0076 , A61M2025/0079 , A61M2025/0085 , A61M2025/0681
摘要： Embodiments of the present application regard the delivery of therapeutic. One such apparatus may comprise multiple, independently-activated, injection devices (140) for the delivery of therapeutic or other substances. This apparatus may include a first catheter (120) ; a second catheter (130) in the first catheter and a multiple delivery member injection device (140) . This multiple delivery member may include an expandable member and a plurality of injection elements (220-224). A third catheter may be positioned in the second catheter. This third catheter may have a distal end connected to a wall of the expandable member and a plurality of filling tubes (230-234) connected to an distal end of the third catheter. In some of the embodiments each of the injection elements may hold a pressurized therapeutic prior to release of the therapeutic .
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5.发明公开ALIGNED SCAFFOLDS FOR IMPROVED MYOCARDIAL REGENERATION 审中-公开AUSGERICHTETEGERÜSTEZUR VERBESSERTEN MYKARDREGENERATION
公开(公告)号：EP1649008A2
公开(公告)日：2006-04-26
申请号：EP04778399.8
申请日：2004-07-15
发明人： FREYMAN, Toby , PALASIS, Maria , UNGS, Mark
CPC分类号： C12N5/00 , A61K35/12 , A61L27/3604 , A61L27/367 , A61L27/54 , A61L27/60 , A61L2300/252 , A61L2300/254 , A61L2300/256 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2300/604 , C12N5/0068 , C12N5/0657 , C12N5/0698 , C12N2502/094 , C12N2502/1323 , C12N2533/74 , C12N2533/92 , C12N2535/10
摘要： The present invention relates to a biocompatible, three-dimensional scaffold useful to grow cells and to regenerate or repair tissue in predetermined orientations. The scaffold is particularly useful for regeneration and repair of cardiac tissue. The scaffold contains layers of alternating A-strips and S-strips, wherein the A-strips within each layer are aligned parallel to each other and preferentially promote cellular attachment over attachment to the S-strips. Methods of producing and implanting the scaffold are also provided.
摘要翻译： 本发明涉及生物相容性的三维支架，其可用于生长细胞并且以预定取向再生或修复组织。 支架对于心脏组织的再生和修复特别有用。 支架包含交替的A条和S条的层，其中每层内的A条彼此平行对准，并优先促进通过附着到S条上的细胞附着。 还提供了生产和植入支架的方法。
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公开(公告)号：EP1562670A2
公开(公告)日：2005-08-17
申请号：EP03768682.1
申请日：2003-11-06
发明人： NAIMARK, Wendy , TUNG, Henry , PALASIS, Maria
CPC分类号： A61B5/145 , A61B5/01 , A61B5/14539 , A61B5/6885 , A61B2017/00022 , A61B2562/028 , A61M2025/0002 , A61M2025/0003 , A61M2205/3344 , A61M2205/3368
摘要： There is provided a minimally-invasive smart device which can detect environmental conditions in the vicinity of a target site within a patient's body and autonomously determine whether the medical device on the distal end of the instrument should be activated to perform, or inhibited from performing, a desired minimally-invasive medical procedure. The smart device includes a medical device affixed to the distal end of a lumen, at least one environmental condition sensor adapted to detect an environmental condition adjacent to the medical device, and at least one medical device actuator which responds to signals from an environmental condition sensor to either cause the medical device to perform the desired medical procedure or to inhibit operation of the medical device actuator.
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公开(公告)号：EP1536849A1
公开(公告)日：2005-06-08
申请号：EP03788499.6
申请日：2003-08-15
CPC分类号： A61L31/10 , A61K9/0024 , A61L31/16 , A61L2300/602 , A61L2300/61 , A61L2420/08
摘要： The present invention relates to microarray polymeric barriers designed to control the release rate of therapeutic agents. By varying the thickness of the coating or affecting, physically and/or chemically, the constituents of the barrier composition, the release profile of the underlying therapeutic agent can be modified and controlled.
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公开(公告)号：EP1135165A1
公开(公告)日：2001-09-26
申请号：EP99961692.3
申请日：1999-11-17
发明人： PALASIS, Maria , SCHWARZ, Marlene
CPC分类号： A61L31/16 , A61K47/6957 , A61L29/08 , A61L29/16 , A61L31/08 , A61L2300/416 , A61L2300/604 , A61L2300/606 , A61L2300/63 , C08L75/04
摘要： A medical device for insertion into a mammalian body, wherein the medical device has a crystalline therapeutic agent thereon. Also provided is a method of delivering a therapeutic agent to a target location within a mammalian body. The method comprises the steps of placing crystals of the therapeutic agent on a medical device, and delivering the medical device to the target location.
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公开(公告)号：EP1986572A2
公开(公告)日：2008-11-05
申请号：EP07710144.2
申请日：2007-01-16
发明人： FREYMAN, Toby , NAIMARK, Wendy , PALASIS, Maria
IPC分类号： A61F2/06
CPC分类号： A61F2/02 , A61F2/0077 , A61F2/07 , A61F2230/008 , A61F2250/0039 , A61F2250/0067
摘要： A medical device includes a carrier and an agent. The agent is formulated to control inflammation of biological tissue, such as heart tissue, and is releasably coupled to the carrier. The carrier (130) is configured to be disposed in operative proximity to the biological tissue to be treated by the agent (120). In one embodiment, the carrier is configured to release the agent or otherwise deliver the agent to the biological tissue, thus controlling inflammation of the tissue. Also, a method to improve healing of biological tissue includes placing a medical device proximate to the heart of a patient, where the medical device has a carrier and an agent configured to control inflammation, the agent is releasably coupled to the carrier. In one embodiment, the method includes causing the agent to be released from the carrier.
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公开(公告)号：EP1933895A2
公开(公告)日：2008-06-25
申请号：EP06803037.8
申请日：2006-09-06
发明人： NAIMARK, Wendy , SHANK, Peter , PALASIS, Maria , FREYMAN, Toby , PANOS, Anastasia , EPSTEIN, Samuel, J. , ROUSSEAU, Alexandra
IPC分类号： A61L31/16
CPC分类号： A61L31/16 , A61F2/91 , A61F2/915 , A61F2002/075 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2220/0008 , A61F2230/0013 , A61F2250/0068 , A61L2300/606
摘要： A medical device for delivering a therapeutic agent to a body lumen is described. The device may generally be a stent with an inner sidewall surface and an outer sidewall surface, with a plurality of struts having a plurality of openings therein. An inner and outer layer may be applied to the stent, forming pockets within at least a portion of the openings. The pockets may be filled with at least one therapeutic agent. The pockets may take a variety of shapes and sizes, and may be designed for release or rupture in variety of ways.
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