公开(公告)号：EP3003395B1

公开(公告)日：2019-07-17

申请号：EP14730463.8

申请日：2014-05-28

申请人： Bracco Imaging S.p.A.

发明人： GHIANI, Simona ,  MAIOCCHI, Alessandro ,  CAMINITI, Lara ,  MIRAGOLI, Luigi

IPC分类号： A61K49/00 ,  A61K9/51 ,  A61K9/10

公开(公告)号：EP2892570B1

公开(公告)日：2019-02-27

申请号：EP13759502.1

申请日：2013-09-06

申请人： Bracco Imaging S.p.A.

发明人： GHIANI, Simona ,  MAIOCCHI, Alessandro ,  BRIOSCHI, Chiara ,  VISIGALLI, Massimo ,  CABELLA, Claudia ,  MIRAGOLI, Luigi

IPC分类号： A61K49/10 ,  A61K49/18

公开(公告)号：EP3003395A1

公开(公告)日：2016-04-13

申请号：EP14730463.8

申请日：2014-05-28

申请人： Bracco Imaging S.p.A

发明人： GHIANI, Simona ,  MAIOCCHI, Alessandro ,  CAMINITI, Lara ,  MIRAGOLI, Luigi

IPC分类号： A61K49/00 ,  A61K9/51 ,  A61K9/107

CPC分类号： A61K49/0093 ,  A61K9/10 ,  A61K9/5123 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0078

摘要： The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.

公开(公告)号：EP2892570A2

公开(公告)日：2015-07-15

申请号：EP13759502.1

申请日：2013-09-06

申请人： Bracco Imaging S.p.A

发明人： GHIANI, Simona ,  MAIOCCHI, Alessandro ,  BRIOSCHI, Chiara ,  VISIGALLI, Massimo ,  CABELLA, Claudia ,  MIRAGOLI, Luigi

IPC分类号： A61K49/10 ,  A61K49/18

CPC分类号： A61K49/106 ,  A61K49/085 ,  A61K49/101 ,  A61K49/1881

摘要： The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field.