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公开(公告)号：EP2950826A1
公开(公告)日：2015-12-09
申请号：EP14704304.6
申请日：2014-01-30
申请人： Bracco Imaging S.p.A
发明人： JENSEN, Pernille Rose , LERCHE, Mathilde H. , KARLSSON, Magnus , CABELLA, Claudia , COLOMBO SERRA, Sonia , MIRAGOLI, Luigi , VENTURI, Luca , TEDOLDI, Fabio
IPC分类号： A61K49/10
摘要： The invention relates to a method of Magnetic Resonance (MR) detection, in particular 13C-MR detection, by using a diagnostic medium comprising a hyperpolarized ester, in particular ethyl acetoacetate. The method comprises the detection of the MR signal of a hyperpolarized 13C carboxylic ester and of its respective hyperpolarized metabolite.
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2.发明公开PARAMAGNETIC SOLID LIPID NANOPARTICLES (PSLNS) CONTAINING METAL AMPHIPHILIC COMPLEXES FOR MRI 审中-公开两亲金属复杂，MRI PARA磁性固体脂质纳米粒
公开(公告)号：EP2892570A2
公开(公告)日：2015-07-15
申请号：EP13759502.1
申请日：2013-09-06
申请人： Bracco Imaging S.p.A
发明人： GHIANI, Simona , MAIOCCHI, Alessandro , BRIOSCHI, Chiara , VISIGALLI, Massimo , CABELLA, Claudia , MIRAGOLI, Luigi
CPC分类号： A61K49/106 , A61K49/085 , A61K49/101 , A61K49/1881
摘要： The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field.
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公开(公告)号：EP2911704B1
公开(公告)日：2019-10-16
申请号：EP13780159.3
申请日：2013-10-24
发明人： JENSEN, Pernille Rose , KARLSSON, Magnus , LERCHE, Mathilde , CABELLA, Claudia , CAMINITI, Lara , COLOMBO SERRA, Sonia , MIRAGOLI, Luigi , POGGI, Luisa , VENTURI, Luca , TEDOLDI, Fabio
IPC分类号： A61K49/10
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4.发明授权
公开(公告)号：EP2892570B1
公开(公告)日：2019-02-27
申请号：EP13759502.1
申请日：2013-09-06
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5.发明授权HYPERPOLARIZED 1-13C-1,1-BIS(ACETOXY(METHYL))-2,2'-CYCLOPROPANE AS METABOLIC MARKER FOR MR 有权高分子量1-13C-1,1-BIS（乙氧基（甲基）） - 2,2'-环丙烷作为MR的代谢指标
公开(公告)号：EP3016687B1
公开(公告)日：2017-08-09
申请号：EP14733656.4
申请日：2014-06-30
发明人： LERCHE, Mathilde , JENSEN, Pernille Rose , KARLSSON, Magnus , NAPOLITANO, Roberta , CABELLA, Claudia , MIRAGOLI, Luigi , COLOMBO SERRA, Sonia , TEDOLDI, Fabio
CPC分类号： A61K51/0402 , A61B5/055 , A61B5/4848 , A61K49/10 , C07B59/001 , C07B2200/05 , C07C69/007 , C07C2601/02
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6.发明公开HYPERPOLARIZED 1-13C-1,1-BIS(ACETOXY(METHYL))-2,2'-CYCLOPROPANE AS METABOLIC MARKER FOR MR 有权高效聚合物1-13C-1,1-BIS（乙氧基（甲基）） - 2,2'-环丙基丙烯酰氧基丙烯酸酯
公开(公告)号：EP3016687A1
公开(公告)日：2016-05-11
申请号：EP14733656.4
申请日：2014-06-30
申请人： Bracco Imaging S.p.A
发明人： LERCHE, Mathilde , JENSEN, Pernille Rose , KARLSSON, Magnus , NAPOLITANO, Roberta , CABELLA, Claudia , MIRAGOLI, Luigi , COLOMBO SERRA, Sonia , TEDOLDI, Fabio
IPC分类号： A61K49/10
CPC分类号： A61K51/0402 , A61B5/055 , A61B5/4848 , A61K49/10 , C07B59/001 , C07B2200/05 , C07C69/007 , C07C2601/02
摘要： 1-
13 C-1,1-Bis(acetoxy(methyl))-2,2'-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in
13 C Magnetic Resonance diagnostic technique (
13 C-MR) for the diagnosis of tumor.摘要翻译： 式（I）的1-13C-1,1-双（乙酰氧基（甲基）） - 2,2'-环丙烷：该化合物可以超极化并用作13C磁共振诊断技术（13C-MR）中的造影剂， 用于诊断肿瘤。
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公开(公告)号：EP2911704A1
公开(公告)日：2015-09-02
申请号：EP13780159.3
申请日：2013-10-24
申请人： Bracco Imaging S.p.A
发明人： JENSEN, Pernille Rose , KARLSSON, Magnus , LERCHE, Mathilde , CABELLA, Claudia , CAMINITI, Lara , COLOMBO SERRA, Sonia , MIRAGOLI, Luigi , POGGI, Luisa , VENTURI, Luca , TEDOLDI, Fabio
IPC分类号： A61K49/10
摘要： Hyperpolarized 1-13C-2-oxoglutarate as contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MRI) for use in the diagnosis of cancer. In particular, upon administration of said 1-13C-2-oxoglutarate, signals of 1-13C-glutamate are detected. More in particular, different MR signals from 13C nuclei are detected and compared, said comparison being useful to determine a difference between tumor and non-tumor tissues, to determine the aggressiveness of a tumor or the efficacy of an anti-tumor therapy.
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