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公开(公告)号：EP3233133A1
公开(公告)日：2017-10-25
申请号：EP15817811.1
申请日：2015-12-18
IPC分类号： A61K49/00
摘要： The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence- guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.
摘要翻译： 本发明涉及在病理区域的荧光引导的手术中包含用Cy5.5染料部分标记的基于氮杂 - 双环烷的环状肽的NIR荧光探针的用途，以及包括使用该荧光探针用于 在手术切除期间对肿瘤边缘的识别和划分。
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2.发明公开DYNAMIC CONTRAST ENHANCED MRI METHOD AND AGENTS FOR THE ASSESSMENT OF THE MACROMOLECULAR TRANSPORT WITHIN PATHOLOGIC TISSUES 审中-公开动态对比度增强MRI的方法和手段大分子运输病理组织的评价
公开(公告)号：EP2822605A1
公开(公告)日：2015-01-14
申请号：EP13709176.5
申请日：2013-03-05
申请人： Bracco Imaging S.p.A
CPC分类号： G01R33/5601 , A61B5/055 , A61K49/085 , A61K49/10 , A61K49/106
摘要： The present invention generally relates to paramagnetic contrast agents and a Dynamic Contrast Enhanced-MRI method for the non-invasive estimation of the delivery of a macromolecular anticancer drug or pro-drug within pathological tissues and, especially, in solid tumors and for the optimization of anticancer therapies.
摘要翻译： 本发明基因的反弹涉及顺磁性造影剂并进行病理组织，爱特别是在实体肿瘤和用于优化内的高分子抗癌药或前体药物的递送的非侵入性的估计的动态对比度增强的MRI方法 抗癌疗法。
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公开(公告)号：EP2320954B1
公开(公告)日：2019-09-04
申请号：EP09800042.5
申请日：2009-07-21
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5.发明公开A NEW CLASS OF DIAZEPINE DERIVATIVE CHELATING AGENTS AND COMPLEXES WITH PARAMAGNETIC METALS THEREOF AS MRI CONTRAST AGENTS 有权DIAZEPINDERIVAT螯合剂和复杂与对磁性金属AS MRI造影剂
公开(公告)号：EP2834222A1
公开(公告)日：2015-02-11
申请号：EP13708844.9
申请日：2013-03-13
申请人： Bracco Imaging S.p.A
发明人： MAIOCCHI, Alessandro , VISIGALLI, Massimo , BELTRAMI, Lorena , SINI, Loredana , LATTUADA, Luciano
IPC分类号： C07D243/08 , A61K31/551
CPC分类号： A61K49/106 , C07D243/08 , C07F9/645
摘要： The present invention relates to a new class of diazepine-derivatives as chel ating agents for paramag netic metal ions, the process for their preparation, and use of such paramagnetic complexes as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
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6.发明公开
公开(公告)号：EP2555803A1
公开(公告)日：2013-02-13
申请号：EP11712872.8
申请日：2011-04-08
申请人： Bracco Imaging S.p.A
发明人： AIME, Silvio , GIOVENZANA, Giovanni, Battista , TEDOLDI, Fabio , MAIOCCHI, Alessandro , UGGERI, Fulvio , JENSEN, Pernille, Rose , KARLSSON, Magnus , LERCHE, Mathilde, H. , VISIGALLI, Massimo , CROSETTI, Marco , POGGI, Luisa
IPC分类号： A61K49/10
摘要： The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.
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公开(公告)号：EP2555803B1
公开(公告)日：2018-09-12
申请号：EP11712872.8
申请日：2011-04-08
发明人： AIME, Silvio , GIOVENZANA, Giovanni, Battista , TEDOLDI, Fabio , MAIOCCHI, Alessandro , UGGERI, Fulvio , JENSEN, Pernille, Rose , KARLSSON, Magnus , LERCHE, Mathilde, H. , VISIGALLI, Massimo , CROSETTI, Marco , POGGI, Luisa
IPC分类号： A61K49/10
摘要： The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.
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公开(公告)号：EP3174558A1
公开(公告)日：2017-06-07
申请号：EP15738943.8
申请日：2015-07-22
发明人： ELISEI, Elena , CESARO, Attilio , FILIBIAN, Marta , CARRETTA, Pietro , COLOMBO SERRA, Sonia , MAIOCCHI, Alessandro , TEDOLDI, Fabio
IPC分类号： A61K49/10
摘要： A method for preparing a sample for dynamic nuclear polarization which comprises submitting a solid substrate to a milling process in the presence of a polarizing agent at a temperature lower than the glass-transition temperature (Tg) of said substrate. Preferably said substrate may be in crystalline form.
摘要翻译： 制备用于动态核极化的样品的方法，该方法包括在低于所述底物的玻璃化转变温度（Tg）的温度下，在极化剂存在下将固体基质提供给研磨过程。 优选地，所述基材可以是结晶形式。
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公开(公告)号：EP2320954A1
公开(公告)日：2011-05-18
申请号：EP09800042.5
申请日：2009-07-21
申请人： Bracco Imaging S.p.A
发明人： ROSSELLO, Armando , NUTI, Elisa , AVRAMOVA, Stanislava Ivanova , UGGERI, Fulvio , MAIOCCHI, Alessandro
IPC分类号： A61K49/00 , A61K49/10 , A61K49/22 , A61K51/04 , A61P43/00 , C07C311/48 , C07D295/08 , C07D295/088
CPC分类号： A61K49/0017 , A61K49/085 , A61K49/10 , A61K49/101 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/221 , A61K51/0497
摘要： The invention relates to aryl-sulphonamido compounds endowed with affinity against metallo proteases MMP, having formula (I) below wherein R, R 1 , R 2 , R 3 , G and n have the meanings reported in the specification, properly labelled with diagnostic imaging moieties or even radiotherapeutic moieties. The invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as diagnostic imaging agents or radiotherapeutic agents.
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公开(公告)号：EP3003395B1
公开(公告)日：2019-07-17
申请号：EP14730463.8
申请日：2014-05-28
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