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公开(公告)号：EP3049529B1
公开(公告)日：2019-04-24
申请号：EP14845077.8
申请日：2014-09-23
申请人： Braskem S.A.
IPC分类号： C12P7/28
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2.发明公开MODIFIED MICROORGANISMS COMPRISING AN OPTIMIZED SYSTEM FOR OLIGOSACCHARIDE UTILIZATION AND METHODS OF USING SAME 审中-公开随着对优化OLIGOSACCHARIDNUTZUNG一个系统及其方法使用修饰的微生物
公开(公告)号：EP3149187A1
公开(公告)日：2017-04-05
申请号：EP15800180.0
申请日：2015-05-29
申请人： Braskem S.A.
CPC分类号： C12N9/90 , C12N9/1048 , C12N9/1051 , C12N9/12 , C12P5/007 , C12P7/06 , C12P19/32 , C12Y204/01001 , C12Y504/02002 , Y02E50/17
摘要： The present disclosure generally relates to modified microorganisms comprising an optimized system for oligosaccharide utilization comprising one or more polynucleotides coding for one or more energy independent oligosaccharide transporters for transporting an oligosaccharide into the microorganism, one or more polynucleotides coding for enzymes that catalyze the conversion of the oligosaccharide into at least one phosphorylated saccharide, and one or more polynucleotides coding for enzymes that catalyze the conversion of the phosphorylated saccharide into an isomer of the phosphorylated saccharide that is utilized in one or more enzymatic pathways in the microorganism for the production of an organic molecule such as acetic acid, acrylic acid, 3-hydroxypropionic acid, lactic acid, etc. The present disclosure also generally relates to methods of using the optimized system for oligosaccharide utilization.
摘要翻译： 本发明基因的反弹涉及修饰的微生物为寡糖利用包括优化的系统，其包含一个或多个多核苷酸编码的一个或多个能量独立寡糖转运寡糖对输送到微生物，一个或多个用于酶更多个多核苷酸编码并催化的转化 寡糖进入至少一个磷酸化糖，以及用于酶的一种或多种多核苷酸的编码做催化磷酸化糖转化成上磷酸化糖确实是在一个或多个酶途径用在微生物用于生产有机分子的异构体 ：例如乙酸，丙烯酸，3-羟基丙酸，乳酸等因此，本发明的基因的反弹涉及使用该优化的系统寡糖利用率的方法。
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3.发明公开ENGINEERED ENZYME HAVING ACETOACETYL-COA HYDROLASE ACTIVITY, MICROORGANISMS COMPRISING SAME, AND METHODS OF USING SAME 审中-公开手工酵母菌脂肪酸乙酯 - 丙二醇缩水甘油酯，密克罗尼西亚丹麦VERFAHREN ZUR VERWENDUNG DAVON
公开(公告)号：EP3049529A1
公开(公告)日：2016-08-03
申请号：EP14845077.8
申请日：2014-09-23
申请人： Braskem S.A.
IPC分类号： C12P7/28
CPC分类号： C12N9/16 , C12N9/13 , C12P7/04 , C12Y301/02011
摘要： The disclosure provides engineered enzymes that are capable of mediating the conversion of acetoacetyl-CoA to acetoacetate that do not react with the same order of magnitude with acetyl-CoA as they do with acetoacetyl-CoA (e.g., the engineered enzymes have a specific acetoacetyl-CoA hydrolase activity at least 10x higher than its acetyl-CoA hydrolase activity). Additionally, the disclosure provides modified microorganisms that comprise the engineered enzymes disclosed herein and methods of using same.
摘要翻译： 本公开提供了能够介导乙酰乙酰辅酶A向乙酰乙酸酯转化而不与乙酰辅酶A与乙酰辅酶A相同量级反应的工程化酶（例如，工程化酶具有特定的乙酰乙酰基 - CoA水解酶活性比其乙酰-CoA水解酶活性高至少10倍）。 另外，本公开提供包含本文公开的工程化酶的修饰微生物及其使用方法。
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4.发明公开
公开(公告)号：EP3536799A2
公开(公告)日：2019-09-11
申请号：EP19164110.9
申请日：2014-09-23
申请人： Braskem S.A.
IPC分类号： C12P7/28
摘要： The disclosure provides engineered enzymes that are capable of mediating the conversion of acetoacetyl-CoA to acetoacetate that do not react with the same order of magnitude with acetyl-CoA as they do with acetoacetyl-CoA (e.g., the engineered enzymes have a specific acetoacetyl-CoA hydrolase activity at least 10x higher than its acetyl-CoA hydrolase activity). Additionally, the disclosure provides modified microorganisms that comprise the engineered enzymes disclosed herein and methods of using same.
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5.发明公开MODIFIED MICROORGANISMS AND METHODS OF MAKING BUTADIENE USING SAME 审中-公开FOR BUTADIENHERSTELLUNG SO修饰的微生物和方法
公开(公告)号：EP2791342A1
公开(公告)日：2014-10-22
申请号：EP12857162.7
申请日：2012-12-17
申请人： Braskem S.A.
发明人： GARCEZ LOPEZ, Mateus Schreiner , SLOVIC, Avram Michael , GOUVEA, Iuri Estrada , PEREZ, Johana Rincones , PARIZZI, Lucas Penderson
CPC分类号： C12P5/026 , C12N9/88 , C12N15/52 , C12P5/02 , C12Y402/01127
摘要： The present disclosure generally relates to microorganisms that comprise one or more polynucleotides coding for enzymes in one or more pathways that catalyze a conversion of a fermentable carbon source to butadiene. Also provided are methods of using the microorganisms in industrial processes including, for use in the production of butadiene and products derived therefrom.
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