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公开(公告)号：EP2089364A1
公开(公告)日：2009-08-19
申请号：EP07844974.1
申请日：2007-11-08
IPC分类号： C07D213/82 , A61K31/444 , A61P35/00
CPC分类号： C07D213/82
摘要： The invention is directed to pyridinone compounds useful for modulating Met kinase, having the following structure: (I) and is further directed to pharmaceutical compositions comprising the compound; and methods for treating proliferative diseases, such as cancer by the administration of this compound.
摘要翻译： 本发明涉及用于调节Met激酶的吡啶酮化合物，其具有以下结构：（I）并进一步涉及包含该化合物的药物组合物; 以及通过给予该化合物治疗增殖性疾病如癌症的方法。
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公开(公告)号：EP2235002A1
公开(公告)日：2010-10-06
申请号：EP09704457.2
申请日：2009-01-22
IPC分类号： C07D401/12 , C07D401/14 , A61K31/4427 , A61P35/00
CPC分类号： C07D401/14 , C07D401/12
摘要： Disclosed are compounds of Formula (I)and salts thereof. Also, disclosed are methods of using the compounds in the treatment of proliferative diseases, such as cancer, and to pharmaceutical compositions comprising at least one compound of Formula (I) or a pharmaceutically acceptable salt.
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公开(公告)号：EP2714681A1
公开(公告)日：2014-04-09
申请号：EP12726525.4
申请日：2012-05-23
发明人： BORZILLERI, Robert M. , CAI, Zhen-wei , TEBBEN, Andrew J. , PEREZ, Heidi L. , ZHANG, Liping , SCHROEDER, Gretchen M. , WEI, Donna D.
IPC分类号： C07D403/10 , C07D403/12 , C07D403/14 , C07D413/12 , A61P35/00 , A61K31/4166
CPC分类号： C07D417/10 , C07D401/10 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/10 , C07D413/12
摘要： Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.
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公开(公告)号：EP1742948A2
公开(公告)日：2007-01-17
申请号：EP05779223.6
申请日：2005-04-26
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The compounds of the instant invention can be used as anticancer agents. More specifically, the invention comprises a compound having Formula (I) or (II),
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公开(公告)号：EP2714681B1
公开(公告)日：2015-06-24
申请号：EP12726525.4
申请日：2012-05-23
发明人： BORZILLERI, Robert M. , CAI, Zhen-wei , TEBBEN, Andrew J. , PEREZ, Heidi L. , ZHANG, Liping , SCHROEDER, Gretchen M. , WEI, Donna D.
IPC分类号： C07D401/10 , C07D413/10 , C07D417/10 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/12
CPC分类号： C07D417/10 , C07D401/10 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/10 , C07D413/12
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公开(公告)号：EP2089364B1
公开(公告)日：2013-06-12
申请号：EP07844974.1
申请日：2007-11-08
IPC分类号： C07D213/82 , A61K31/444 , A61P35/00
CPC分类号： C07D213/82
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公开(公告)号：EP2235002B1
公开(公告)日：2012-11-21
申请号：EP09704457.2
申请日：2009-01-22
IPC分类号： C07D401/12 , C07D401/14 , A61K31/4427 , A61P35/00
CPC分类号： C07D401/14 , C07D401/12
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8.发明授权HYDROXYPHENYLSULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS 有权HYDROXYPHENYLSULFONSÄUREAMIDEALS抗凋亡BCL-抑制剂
公开(公告)号：EP2297103B1
公开(公告)日：2012-01-04
申请号：EP09763373.9
申请日：2009-06-08
IPC分类号： C07D213/65 , C07D213/68 , C07D213/71 , C07D213/81 , C07D213/40 , C07D277/64 , C07D403/04 , C07C15/04 , A61K31/4406 , A61P35/00
CPC分类号： C07D213/81 , C07D213/40 , C07D213/65 , C07D213/68 , C07D213/71 , C07D277/64 , C07D403/04
摘要： The present invention provides compound of Formula (I): or a stereoisomer, tautomer, salt or solvate thereof, wherein the variables are defined herein. The compounds of formula (I) are inhibitors of Bcl-2 family antiapoptotic proteins, compositions containing the compounds and methods of treating diseases using the compounds.
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公开(公告)号：EP2297103A1
公开(公告)日：2011-03-23
申请号：EP09763373.9
申请日：2009-06-08
IPC分类号： C07D213/65 , C07D213/68 , C07D213/71 , C07D213/81 , C07D213/40 , C07D277/64 , C07D403/04 , C07C15/04 , A61K31/4406 , A61P35/00
CPC分类号： C07D213/81 , C07D213/40 , C07D213/65 , C07D213/68 , C07D213/71 , C07D277/64 , C07D403/04
摘要： The present invention provides compound of Formula (I): or a stereoisomer, tautomer, salt or solvate thereof, wherein the variables are defined herein. The compounds of formula (I) are inhibitors of Bcl-2 family antiapoptotic proteins, compositions containing the compounds and methods of treating diseases using the compounds.
摘要翻译： 本发明提供了式（I）化合物：或其立体异构体，互变异构体，盐或溶剂化物，其中变量如本文所定义。 式（I）化合物是Bcl-2家族抗凋亡蛋白的抑制剂，含有该化合物的组合物和使用该化合物治疗疾病的方法。
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公开(公告)号：EP1773837A2
公开(公告)日：2007-04-18
申请号：EP05785021.6
申请日：2005-06-15
发明人： CAI, Zhen-wei , LOMBARDO, Louis J. , BHIDE, Rajeev S. , QIAN, Ligang , WEI, Donna D. , BARBOSA, Stephanie
IPC分类号： C07D487/04 , C07D487/12 , A61K31/53 , A61P19/02 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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