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公开(公告)号：EP1267880B2
公开(公告)日：2010-01-20
申请号：EP01955090.4
申请日：2001-01-26
发明人： COLONNO, Richard, J. , SPROCKEL, Omar, L. , HARIANAWALA, Abizer , DESAI, Divyakant , FAKES, Michael, G.
CPC分类号： A61K9/2054 , A61K9/2018 , A61K9/2027 , A61K9/2866 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K31/52 , A61K31/522
摘要： Compositions containing a low dose of entecavir are administered on a daily basis to treat hepatitis B virus infection and/or co-infections. Formulations for the oral administration of a low dose of entecavir are provided. Other pharmaceutically active substances can be included in the entecavir composition or can be separately administered for the treatment of hepatitis B virus infection or for the treatment of co-infected patients.
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公开(公告)号：EP1492510A1
公开(公告)日：2005-01-05
申请号：EP03746598.6
申请日：2003-04-03
发明人： DESAI, Divyakant , LI, Danping
CPC分类号： A61K9/0095 , A61K31/522
摘要： Liquid pharmaceutical compositions are provided having a low dose of entecavir. In one embodiment of the present invention, the liquid entecavir composition is a ready-to-use composition that is formulated to be both stable and palatable. In a second embodiment of the present invention, the liquid entecavir composition is formulated from a powder composition at the time of use. The low dose entecavir compositions may also include at least one component selected from sweetener, preservative, flavoring agent, buffering agent, or combinations thereof. The liquid entecavir compositions may also be formulated in combination with other pharmaceutically active agents.
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公开(公告)号：EP1753406A1
公开(公告)日：2007-02-21
申请号：EP05756474.2
申请日：2005-05-26
发明人： DESAI, Divyakant , LI, Bing V.
IPC分类号： A61K9/24 , A61K31/403
CPC分类号： A61K9/2886 , A61K9/2086 , A61K9/284 , A61K31/403
摘要： A coated tablet formulation is provided which includes a medicament such as the DPP4-inhibitor, saxaglipitin, formula (I), or its HCl salt, which is subject to intra-molecular cyclization, which formulation includes a tablet core containing one or more fillers, and other conventional excipients, which tablet core includes a coating thereon which may include two or more layers, at least one layer of which is an inner seal coat layer which is formed of one or more coating polymers, a second layer of which is formed of medicament which is the DPP4-inhibitor and one or more coating polymers, and an optional, but preferable third outer protective layer which is formed of one or more coating polymers. A method for forming the coated tablet is also provided.
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公开(公告)号：EP4422690A1
公开(公告)日：2024-09-04
申请号：EP22813809.5
申请日：2022-10-27
发明人： LAVAN, Monika , KESTUR, Umesh , DESAI, Divyakant , EVANS, Charles , SAYER, James , GUIDALI, Florencia
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公开(公告)号：EP2498758A2
公开(公告)日：2012-09-19
申请号：EP10782113.4
申请日：2010-11-12
IPC分类号： A61K9/20
CPC分类号： A61K9/209 , A61K9/2054 , A61K9/282 , A61K31/155 , A61K31/403 , A61K31/70 , A61K31/7004 , A61K31/7034 , A61K31/7042 , A61K45/06 , A61K2300/00
摘要： The present invention relates to bilayer tablets comprising a metformin hydrochloride formulation as the first layer, an SGLT2 inhibitor formulation as the second layer, and optionally a film coating. The present invention further relates to medical uses of said bilayer tablets and to pharmaceutical combinations comprising said bilayer tablets.
摘要翻译： 本发明涉及包含作为第一层的二甲双胍延长释放（XR）或二甲双胍二甲双胍XR制剂的二片剂，作为第二层的SGLT2抑制剂制剂和任选的膜包衣的双层片剂制剂。 本发明提供制备双层片剂制剂的方法和使用双层片剂制剂治疗与SGLT2活性相关的疾病或病症的方法。
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公开(公告)号：EP1267880B1
公开(公告)日：2005-12-14
申请号：EP01955090.4
申请日：2001-01-26
发明人： COLONNO, Richard, J. , SPROCKEL, Omar, L. , HARIANAWALA, Abizer , DESAI, Divyakant , FAKES, Michael, G.
CPC分类号： A61K9/2054 , A61K9/2018 , A61K9/2027 , A61K9/2866 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K31/52 , A61K31/522
摘要： Compositions containing a low dose of entecavir are administered on a daily basis to treat hepatitis B virus infection and/or co-infections. Formulations for the oral administration of a low dose of entecavir are provided. Other pharmaceutically active substances can be included in the entecavir composition or can be separately administered for the treatment of hepatitis B virus infection or for the treatment of co-infected patients.
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