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1.发明公开CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF 有权的结晶形式的（S）-7 - （[1,2,4]三唑并[1,5-a]吡啶-6-基）-4-（3,4-二氯苯基）-1,2,3,4- 啉及其用途
公开(公告)号：EP2429293A1
公开(公告)日：2012-03-21
申请号：EP10775425.1
申请日：2010-05-11
发明人： WEI, Chenkou , ROSSO, Victor, W. , GAO, Qi
CPC分类号： A61K31/4725 , A61K31/437 , A61K31/438 , A61K31/495 , A61K45/06 , C07D471/04
摘要： Novel [1,2,4]triazolo[1,5-
a ]pyridinyl-6-yl-substituted tetrahydroisoquinolines are described in the present invention. These compounds and crystalline forms SA1 and N-2 are used in the treatment of various neurological and physiological disorders. Methods of making these compounds and crystalline forms SA-1 and N-2 are also described in the present invention.-
2.发明授权PROCESS FOR PREPARING TRIAZOLE SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES AND NOVEL SALT FORMS PRODUCED THEREIN 有权制备三唑取代的阿拉伯糖氧基哌嗪衍生物和其中产生的新盐形式的方法
公开(公告)号：EP1907389B1
公开(公告)日：2011-07-27
申请号：EP06785355.6
申请日：2006-06-21
发明人： SOUNDARARAJAN, Nachimuthu , QIU, Yuping , HU, Wenhao , KRONENTHAL, David, R. , SIRARD, Pierre , LAJEUNESSE, Jean , DROGHINI, Roberto , CHIDAMBARAM, Ramakrishnan , QIAN, Xinhua , NATALIE, JR., Kenneth, J. , PACK, Shawn, K. , REISING, Nathan , TANG, Erqing , FAKES, Michael, G. , GAO, Qi , QIAN, Feng , VAKKALAGADDA, Blisse, J. , LAI, Chiajen , KUANG, Shan-Ming
IPC分类号： C07D471/04 , A61K31/4745 , A61P31/12
CPC分类号： C07D471/04 , C07C311/49 , C07D213/26
摘要： A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
摘要翻译： 提供了制备三唑取代的氮杂吲哚氧乙酸哌嗪衍生物的方法。 还提供了在上述方法中制备的新型中间体，以及1,2,3-三唑取代的氮杂吲哚氧乙酸哌嗪衍生物的新型N-1和无定形形式以及制备这种新型形式的方法。
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3.发明公开CRYSTALLINE FORM OF METHYL ((1S)-1-(((2S)-2-(5-(4'-(2-((2S)-1-((2S)-2-((METHOXYCARBONYL)AMINO)-3-METHYLBUTANOYL)-2-PYRROLIDINYL)-1H-IMIDAZOL-5-YL)-4-BIPHENYLYL)-1H-IMIDAZOL-2-YL)-1-PYRROLIDINYL)CARBONYL)-2-METHYLPROPYL)CARBAMATE DIHYDROCHLORIDE SALT 有权（1S）-1 - （（2S）-2-（5-（4' - （2 - （（2S）-1 - （（2S）-2 - （（甲氧基羰基）氨基） 3-甲基丁酰基）-2-吡咯烷基）-1H-咪唑-5-基）-4-联苯基）-1H-咪唑-2-基）-1-吡咯烷基）羰基）-2-甲基丙基）CARBAMAT-DIHYDROCHLORIDSALZ
公开(公告)号：EP2183244A1
公开(公告)日：2010-05-12
申请号：EP08796938.2
申请日：2008-07-31
发明人： KIM, Soojin , GAO, Qi , YANG, Fukang
IPC分类号： C07D403/12 , A61K31/4178 , A61P31/12
CPC分类号： C07D403/04
摘要： The present disclosure generally relates to a crystalline form of methyl ((1S)-1-(((2S>2-(5-(4'-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)- 1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt. The present disclosure also generally relates to a pharmaceutical composition comprising a crystalline form, as well of methods of using a crystalline form in the treatment of Hepatitis C and methods for obtaining such crystalline form.
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4.发明授权CRYSTALLINE FORM OF METHYL ((1S)-1-(((2S)-2-(5-(4'-(2-((2S)-1-((2S)-2-((METHOXYCARBONYL)AMINO)-3-METHYLBUTANOYL)-2-PYRROLIDINYL)-1H-IMIDAZOL-5-YL)-4-BIPHENYLYL)-1H-IMIDAZOL-2-YL)-1-PYRROLIDINYL)CARBONYL)-2-METHYLPROPYL)CARBAMATE DIHYDROCHLORIDE SALT 有权（（（2S）-2-（5-（4“ - - （2 - （（2S）-1 - （（2S）-2 - （（甲氧基羰基）氨基）甲基（（1S）-1-结晶形式 - 3-甲基丁酰基）-2-吡咯烷基）-1H-咪唑-5-基）-4-联苯基）-1H-咪唑-2-基）-1-吡咯烷基）羰基）-2-甲基丙基）氨基甲酸叔丁酯，二盐酸盐
公开(公告)号：EP2183244B1
公开(公告)日：2013-01-23
申请号：EP08796938.2
申请日：2008-07-31
发明人： KIM, Soojin , GAO, Qi , YANG, Fukang
IPC分类号： C07D403/12 , A61K31/4178 , A61P31/12
CPC分类号： C07D403/04
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5.发明授权CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF 有权的结晶形式的（S）-7 - （[1,2,4]三唑并[1,5-a]吡啶-6-基）-4-（3,4-二氯苯基）-1,2,3,4- 啉及其用途
公开(公告)号：EP2429293B1
公开(公告)日：2014-10-29
申请号：EP10775425.1
申请日：2010-05-11
发明人： WEI, Chenkou , ROSSO, Victor, W. , GAO, Qi
CPC分类号： A61K31/4725 , A61K31/437 , A61K31/438 , A61K31/495 , A61K45/06 , C07D471/04
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6.发明公开CRYSTALLINE FORM OF 6-Ý(4S)-2-METHYL-4-(2-NAPHTHYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-7-YL¨PYRIDAZIN-3-AMINE 有权KRISTALLINE FORM VON 6 - [（4S）-2-甲基-4-（2-萘基）-1,2,3,4-四氢-1H-吲哚-3-基]吡啶-3-胺
公开(公告)号：EP2280955A2
公开(公告)日：2011-02-09
申请号：EP09759417.0
申请日：2009-06-04
发明人： QIU, Jun , GAO, Qi , LIU, Shuang , HU, Min , YANG, Yuh-lin, Allen , ISHERWOOD, Matthew , AMIN, Rasidul
IPC分类号： C07D401/04 , A61K31/501 , A61P3/04 , A61P25/24
CPC分类号： C07F5/04 , C07C215/20 , C07C217/58 , C07C223/02 , C07D217/04 , C07D237/20 , C07D401/04 , C07D413/10 , C07F5/022 , C07F5/025
摘要： The present disclosure generally relates to a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form, as well of methods of using a crystalline form in the treatment of depression and other conditions and methods for obtaining such crystalline form.
摘要翻译： 本公开内容通常涉及6 - [（4S）-2-甲基-4-（萘基）-1,2,3,4-四氢异喹啉-7-基]哒嗪-3-胺的结晶形式。 本公开还通常涉及包含结晶形式的药物组合物，以及在治疗抑郁症和其它病症中使用结晶形式的方法以及获得这种结晶形式的方法。
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7.发明公开CRYSTALLINE FORMS OF 1-BENZOYL-4-[2-]4-METHOXY-7-(3-METHYL-1H-1,2,4-TRIAZOL-1-YL)-1-[(PHOSPHONOOXY)METHYL]-1H-PYRROLO[2,3-C]PYRIDIN-3-YL[-1,2-DIOXOETHYL]-PIPERAZINE 审中-公开（2-甲基-1H-吡唑-1-基）-1 - [（膦酰氧基）甲基] -1H-吡唑-1-酮 吡咯并[2,3-c]吡啶-3-基[-1,2-二氧代乙基] - 哌嗪
公开(公告)号：EP1963342A2
公开(公告)日：2008-09-03
申请号：EP06848592.9
申请日：2006-12-13
发明人： CHEN, Chung-Pin H. , DIGIUGNO, Dawn , GAO, Qi , GU, Chong-Hui , LEVONS, Jaquan Kalani , YANG, Bing-Shiou
IPC分类号： C07F9/09 , C07D471/04 , A61K31/437 , A61P31/18
CPC分类号： C07D471/04 , C07F9/6561
摘要： The instant disclosure provides crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine, salts and solvates thereof. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form(s), as well of methods of using the crystalline form(s) in the treatment of HIV and/or AIDS, and methods for obtaining such crystalline form(s).
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8.发明公开PROCESS FOR PREPARING TRIAZOLE SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES AND NOVEL SALT FORMS PRODUCED THEREIN 有权用于生产TRIAZOLSUBSTITUIERTENAZAINDOLOXOESSIGSÄUREPIPERAZINDERIVATENWHILE产生了新的盐形式
公开(公告)号：EP1907389A2
公开(公告)日：2008-04-09
申请号：EP06785355.6
申请日：2006-06-21
发明人： SOUNDARARAJAN, Nachimuthu , QIU, Yuping , HU, Wenhao , KRONENTHAL, David, R. , SIRARD, Pierre , LAJEUNESSE, Jean , DROGHINI, Roberto , CHIDAMBARAM, Ramakrishnan , QIAN, Xinhua , NATALIE, JR., Kenneth, J. , PACK, Shawn, K. , REISING, Nathan , TANG, Erqing , FAKES, Michael, G. , GAO, Qi , QUIAN, Feng , VAKKALAGADDA, Blisse, J. , LAI, Chiajen , KUANG, Shan-Ming
IPC分类号： C07D471/04 , A61K31/4745 , A61P31/12
CPC分类号： C07D471/04 , C07C311/49 , C07D213/26
摘要： A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
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