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1.发明公开PREPARATION OF (S)-2-AMINO-6,6-DIMETHOXYHEXANOIC ACID METHYL ESTER VIA NOVEL DIOXOLANES 审中-公开（S）-2-氨基-6,6-二甲氧基己酸甲酯通过新型二氧化硅的制备
公开(公告)号：EP1121351A2
公开(公告)日：2001-08-08
申请号：EP99932163.1
申请日：1999-07-01
发明人： GODFREY, Jollie, D., Jr. , KRONENTHAL, David, R. , SCHWINDEN, Mark, D. , SRIVASTAVA, Sushil, K. , RAMIG, Keith , VENIT, John, J. , JASS, Paul, A. , RACHA, Saibaba , DILLON, John, L., Jr. , SOUNDARARAJAN, Nachimuthu , POWERS, Gerald, L. , KOTNIS, Atul, S.
IPC分类号： C07D317/26 , C07D317/28
CPC分类号： C07C229/22 , C07D317/30
摘要： The invention relates to the synthesis of 2-amino-6, 6-dimethoxy hexanoic acid, methyl ester and novel dioxalane intermediates thereof, from the reaction of glycinamide of formula I with dioxolane of formula II.
摘要翻译： 本发明涉及由式I的甘氨酰胺与式II的二氧戊环反应合成2-氨基-6,6-二甲氧基己酸，甲酯和其新二氧杂环戊烷中间体。
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公开(公告)号：EP1644384B1
公开(公告)日：2012-10-31
申请号：EP03812974.8
申请日：2003-12-10
发明人： PENDRI, Yadagiri, R. , CHEN, Chung-Pin, H. , PATEL, Sunil, S. , EVANS, Jeffrey, M. , LIANG, Jing , KRONENTHAL, David, R. , POWERS, Gerald, L. , PRASAD, Siva, Josyula , BIEN, Jeffrey, T. , SHI, Zhongping , PATEL, Ramesh, N. , CHAN, Yeung, Y. , RIJHWANI, Sushil, K. , SINGH, Ambarish, K. , WANG, Shaopeng , STOJANOVIC, Milan , POLNIASZEK, Richard , LEWIS, Charles , THOTTATHIL, John , KRISHNAMURTY, Dhileepkumar , ZHOU, Maotang X. , VEMISHETTI, Purushotham , BANERJEE, Amit , KUCERA, David, J.
IPC分类号： C07D473/18 , C07F7/08 , C07F7/18
CPC分类号： C07F7/1856 , C07D473/18 , C07F7/0812 , C07F7/0814 , C07F7/0818 , C07F7/0827 , C07F7/083
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3.发明授权PROCESS FOR PREPARING TRIAZOLE SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES AND NOVEL SALT FORMS PRODUCED THEREIN 有权制备三唑取代的阿拉伯糖氧基哌嗪衍生物和其中产生的新盐形式的方法
公开(公告)号：EP1907389B1
公开(公告)日：2011-07-27
申请号：EP06785355.6
申请日：2006-06-21
发明人： SOUNDARARAJAN, Nachimuthu , QIU, Yuping , HU, Wenhao , KRONENTHAL, David, R. , SIRARD, Pierre , LAJEUNESSE, Jean , DROGHINI, Roberto , CHIDAMBARAM, Ramakrishnan , QIAN, Xinhua , NATALIE, JR., Kenneth, J. , PACK, Shawn, K. , REISING, Nathan , TANG, Erqing , FAKES, Michael, G. , GAO, Qi , QIAN, Feng , VAKKALAGADDA, Blisse, J. , LAI, Chiajen , KUANG, Shan-Ming
IPC分类号： C07D471/04 , A61K31/4745 , A61P31/12
CPC分类号： C07D471/04 , C07C311/49 , C07D213/26
摘要： A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
摘要翻译： 提供了制备三唑取代的氮杂吲哚氧乙酸哌嗪衍生物的方法。 还提供了在上述方法中制备的新型中间体，以及1,2,3-三唑取代的氮杂吲哚氧乙酸哌嗪衍生物的新型N-1和无定形形式以及制备这种新型形式的方法。
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4.发明公开PROCESS FOR THE PREPARATION OF 3,7-DISUBSTITUTED-2,3,4,5- TETRAHYDRO-1H-1,4-BENZODIAZEPINE COMPOUNDS 审中-公开用于生产3,7-二取代的2,3,4,5-四氢-1H-1,4-苯并二氮杂化合物
公开(公告)号：EP1443936A2
公开(公告)日：2004-08-11
申请号：EP02793948.7
申请日：2002-11-12
IPC分类号： A61K31/55 , A61P35/00 , C07D233/66 , C07D233/90 , C07D243/14 , C07D333/32 , C07D333/34 , C07C255/00 , C07F7/04 , C07F7/10
CPC分类号： C07D233/64 , C07C255/58 , C07C255/61 , C07D243/14 , C07D333/34 , C07D403/06 , C07D409/12 , C07D409/14 , C07F7/1852
摘要： Methods for the synthesis of benzodiazepine compounds having farnesyl protein transferase inhibitory activity.
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公开(公告)号：EP1089973A1
公开(公告)日：2001-04-11
申请号：EP99930402.5
申请日：1999-06-18
发明人： BISACCHI, Gregory , SLUSARCHYK, William, A. , TREUNER, Uwe , SUTTON, James, C. , ZAHLER, Robert , SEILER, Steven , KRONENTHAL, David, R. , RANDAZZO, Michael, E. , XU, Zhongmin , SHI, Zhongping , SCHWINDEN, Mark, D.
IPC分类号： C07D205/08 , C07D205/09
CPC分类号： C07D403/12 , C07D205/08
摘要： Compounds of formulae (I), (II), (III).
摘要翻译： 式（I），（II），（III）的化合物。
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公开(公告)号：EP2852583A1
公开(公告)日：2015-04-01
申请号：EP13725545.1
申请日：2013-05-22
发明人： ORTIZ, Adrian , BENKOVICS, Tamas , SHI, Zhongping , DESHPANDE, Prashant, P. , GUO, Zhiwei , KRONENTHAL, David, R. , SFOUGGATAKIS, Chris
IPC分类号： C07D309/10 , C07D407/04 , C07D307/20
CPC分类号： C07H15/20 , C07D307/20 , C07D309/10 , C07D407/04 , C07H19/06 , C12P19/385
摘要： A process for making the compound of Formula I utilizes the starting compound, together with sulfilimine and sulfoxide process steps later on.
摘要翻译： 用于制备式I化合物的方法利用起始化合物以及稍后的硫亚胺和亚砜工艺步骤。
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公开(公告)号：EP1644384A2
公开(公告)日：2006-04-12
申请号：EP03812974.8
申请日：2003-12-10
发明人： PENDRI, Yadagiri, R. , CHEN, Chung-Pin, H. , PATEL, Sunil, S. , EVANS, Jeffrey, M. , LIANG, Jing , KRONENTHAL, David, R. , POWERS, Gerald, L. , PRASAD, Siva, Josyula , BIEN, Jeffrey, T. , SHI, Zhongping , PATEL, Ramesh, N. , CHAN, Yeung, Y. , RIJHWANI, Sushil, K. , SINGH, Ambarish, K. , WANG, Shaopeng , STOJANOVIC, Milan , POLNIASZEK, Richard , LEWIS, Charles , THOTTATHIL, John , KRISHNAMURTY, Dhileepkumar , ZHOU, Maotang X. , VEMISHETTI, Purushotham , BANERJEE, Amit , KUCERA, David, J.
IPC分类号： C07F7/08 , C07F7/18 , C07D473/18
CPC分类号： C07F7/1856 , C07D473/18 , C07F7/0812 , C07F7/0814 , C07F7/0818 , C07F7/0827 , C07F7/083
摘要： Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
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8.发明公开PROCESS FOR PREPARING TRIAZOLE SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES AND NOVEL SALT FORMS PRODUCED THEREIN 有权用于生产TRIAZOLSUBSTITUIERTENAZAINDOLOXOESSIGSÄUREPIPERAZINDERIVATENWHILE产生了新的盐形式
公开(公告)号：EP1907389A2
公开(公告)日：2008-04-09
申请号：EP06785355.6
申请日：2006-06-21
发明人： SOUNDARARAJAN, Nachimuthu , QIU, Yuping , HU, Wenhao , KRONENTHAL, David, R. , SIRARD, Pierre , LAJEUNESSE, Jean , DROGHINI, Roberto , CHIDAMBARAM, Ramakrishnan , QIAN, Xinhua , NATALIE, JR., Kenneth, J. , PACK, Shawn, K. , REISING, Nathan , TANG, Erqing , FAKES, Michael, G. , GAO, Qi , QUIAN, Feng , VAKKALAGADDA, Blisse, J. , LAI, Chiajen , KUANG, Shan-Ming
IPC分类号： C07D471/04 , A61K31/4745 , A61P31/12
CPC分类号： C07D471/04 , C07C311/49 , C07D213/26
摘要： A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
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公开(公告)号：EP1089973B1
公开(公告)日：2005-11-09
申请号：EP99930402.5
申请日：1999-06-18
发明人： BISACCHI, Gregory , SLUSARCHYK, William, A. , TREUNER, Uwe , SUTTON, James, C. , ZAHLER, Robert , SEILER, Steven , KRONENTHAL, David, R. , RANDAZZO, Michael, E. , XU, Zhongmin , SHI, Zhongping , SCHWINDEN, Mark, D.
IPC分类号： C07D205/08 , C07D205/09 , C07D403/12 , C07D401/06 , C07D403/06 , A61K31/395
CPC分类号： C07D403/12 , C07D205/08
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公开(公告)号：EP1051419A1
公开(公告)日：2000-11-15
申请号：EP98963113.0
申请日：1998-12-11
发明人： KRONENTHAL, David, R. , DENZEL, Theodor , CHEN, Bang-Chi , SIMPSON, James, H. , DESHPANDE, Rajendra, P.
IPC分类号： C07D471/02 , C07D513/04
CPC分类号： C07D513/04 , C07D223/12
摘要： Acylmercaptoalkanoylamino lactam esters or acids are converted to the corresponding mercaptoalkanoylamino lactam ester or acid under basic conditions by including an agent which minimizes the amount of disulfides. Suitable agents are bismercaptans, phosphine or phosphite reducing agents, zinc metal powder, and sodium hydrosulfite. Such agents are also employed in the recrystallization and reprocessing of the mercaptoalkanoylamino lactam acids.
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