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公开(公告)号：EP1581543A2
公开(公告)日：2005-10-05
申请号：EP03800231.7
申请日：2003-12-23
发明人： DESHPANDE, Prashant, P. , ELLSWORTH, Bruce, A. , SINGH, Janak , LAI, Chiajen , CRISPINO, Gerard , RANDAZZO, Michael, E. , GOUGOUTAS, Jack, Z. , DENZEL, Theodor, W.
CPC分类号： C07H23/00 , C07H5/04 , C07H5/06 , C07H7/00 , C07H15/207
摘要： Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.
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公开(公告)号：EP1056722B1
公开(公告)日：2002-06-12
申请号：EP98964878.7
申请日：1998-12-22
IPC分类号： C07D213/02 , A61K31/44 , C07D213/42
CPC分类号： C07D213/42
摘要： The present invention provides the crystalline bisulfate salt of formula (II) which is found to have unexpectedly high solubility/dissolution rate and oral bioavailability relative to the free base form of this azapeptide HIV protease inhibitor compound.
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3.发明公开CRYSTALLINE SOLVATES AND COMPLEXES OF (IS) -1, 5-ANHYDRO-L-C- (3- ( (PHENYL) METHYL) PHENYL) -D-GLUCITOL DERIVATIVES WITH AMINO ACIDS AS SGLT2 INHIBITORS FOR THE TREATMENT OF DIABETES 有权结晶的（1S）的溶剂化物-1,5-脱水-1-C-（3 - （（苯基）甲基）苯基）与醇作为SGLT2抑制剂用于糖尿病的治疗-D-葡萄糖醇衍生物
公开(公告)号：EP2069374A1
公开(公告)日：2009-06-17
申请号：EP07784499.1
申请日：2007-06-21
发明人： GOUGOUTAS, Jack, Z. , LOBINGER, Hildegard , RAMAKRISHNAN, Srividya , DESHPANDE, Prashant, P. , BIEN, Jeffrey, T. , LAI, Chiajen , WANG, Chenchi , RIEBEL, Peter , GROSSO, John, Anthony , NIRSCHL, Alexandra, A. , SINGH, Janak , DIMARCO, John, D.
CPC分类号： C07H15/207 , A61K31/7034 , A61K45/06 , A61P3/10 , C07H7/04
摘要： The present invention relates to physical crystal structures of a compound of the formula I: wherein R 1 , R 2 , R 2a , R 3 and R 4 are as defined herein, especially pharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
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公开(公告)号：EP1056722A1
公开(公告)日：2000-12-06
申请号：EP98964878.7
申请日：1998-12-22
IPC分类号： C07D213/02 , A61K31/44
CPC分类号： C07D213/42
摘要： The present invention provides the crystalline bisulfate salt of formula (II) which is found to have unexpectedly high solubility/dissolution rate and oral bioavailability relative to the free base form of this azapeptide HIV protease inhibitor compound.
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