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公开(公告)号：EP4157833A1
公开(公告)日：2023-04-05
申请号：EP21733338.4
申请日：2021-05-27
IPC分类号： C07D405/14 , C07D417/14 , A61P29/00 , A61P35/00
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公开(公告)号：EP1644335A1
公开(公告)日：2006-04-12
申请号：EP04778086.1
申请日：2004-07-12
发明人： SUN, Chong-Qing , SITKOFF, Doree , EWING, William, R. , HUANG, Yanting , ELLSWORTH, Bruce, A. , SULSKY, Richard, B. , GU, Zhengxiang , MURUGESAN, Natesan , GERRITZ, Samuel , PENDRI, Annapurna
IPC分类号： C07D215/38 , A61K31/47
CPC分类号： C07D417/06 , C07D215/38 , C07D215/48 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention provides for compounds of formula (I); wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of eating disorders, metabolic disorders, obesity, cognitive disorders, neurological disorders, pain disorders, inflammation disorders, in the promotion of smoking cessation and for the treatment of other psychiatric disorders Also provided are pharmaceutical compositions containing such compounds and pharmaceutical combinations of the compounds of the invention with other therapeutic agents.
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公开(公告)号：EP3953349A1
公开(公告)日：2022-02-16
申请号：EP20722856.0
申请日：2020-04-08
发明人： LIU, Chunjian , FENG, Jianxin , DEVASTHALE, Pratik , MURUGESAN, Natesan , ELLSWORTH, Bruce, A. , REGUEIRO-REN, Alicia , NARA, Susheel Jethanand , JALAGAM, Prasada Rao , PANDA, Manoranjan
IPC分类号： C07D405/04 , C07D407/14 , C07D409/14 , C07D417/14 , A61K31/4192 , A61P1/16 , A61P9/00 , A61P17/00 , A61P29/00 , A61P35/00
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公开(公告)号：EP1697371B1
公开(公告)日：2007-04-25
申请号：EP04815007.2
申请日：2004-12-17
发明人： GU, Guixue , EWING, William, R. , MIKKILINENI, Amarendra, B. , PENDRI, Annapurna , ELLSWORTH, Bruce, A. , SHER, Philip, M. , GERRITZ, Samuel , SUN, Chongqing , MURUGESAN, Natesan , WU, Ximao
IPC分类号： C07D487/04 , A61K31/5025 , A61P37/02 , A61P25/16
CPC分类号： C07D487/04
摘要： The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I. including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R4, R5, m and n are described herein.
摘要翻译： 本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物以及使用式I化合物单独治疗并且与一种或多种另外的 治疗剂。 所述化合物具有通式I，包括所有前药，药学上可接受的盐和立体异构体，R 1，R 2，R 3，R 4，R 5，m和n如本文所述。
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公开(公告)号：EP1697370A1
公开(公告)日：2006-09-06
申请号：EP04814952.0
申请日：2004-12-17
发明人： YU, Guixue , EWING, William, R. , MIKKILINENI, Amarendra, B. , PENDRI, Annapurna , SHER, Philip, M. , GERRITZ, Samuel , ELLSWORTH, Bruce, A. , WU, Gang , HUANG, Yanting , SUN, Chongqing , MURUGESAN, Natesan , GU, Zhengxiang , WANG, Ying , SITKOFF, Doree , JOHNSON, Stephen, R. , WU, Ximao
IPC分类号： C07D487/04 , A61K31/5025 , A61P37/02 , A61P25/16 , C07D249/00 , C07D237/00
CPC分类号： C07D487/04
摘要： The present application describes compounds according to Formula (I), pharmaceutical compositions comprising at least one compound according to Formula (I) and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula (I) both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula (I) including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R6, R7, m and n are described herein.
摘要翻译： 本申请描述了根据式（I）的化合物，包含至少一种根据式（I）的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用式（I）化合物单独和在 与一种或多种另外的治疗剂组合。 化合物具有通式（I），包括所有的前药，药学上可接受的盐和立体异构体，R 1，R 2，R 3，R 6，R 7，m和n如本文所述。
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公开(公告)号：EP2925749B1
公开(公告)日：2016-10-26
申请号：EP13795973.0
申请日：2013-11-15
发明人： ELLSWORTH, Bruce, A. , SHI, Jun , EWING, William, R. , JURICA, Elizabeth, A. , HERNANDEZ, Andres, S. , WU, Ximao , GU, Zhengxiang , HONG, Zhenqiu , O'CONNOR, Stephen, P.
IPC分类号： C07D405/14 , C07D401/12 , C07D405/12 , C07D417/14 , C07D451/06 , C07D403/12 , C07D401/10 , C07D487/08 , C07D211/16 , C07D211/18 , C07D413/14 , A61K31/4155 , A61P3/10 , C07D401/14
CPC分类号： C07D401/12 , A61K31/4155 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/497 , A61K31/506 , A61K31/55 , A61K45/06 , C07D401/10 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D451/06 , C07D471/08 , C07D487/08
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公开(公告)号：EP2925741A1
公开(公告)日：2015-10-07
申请号：EP13795972.2
申请日：2013-11-15
发明人： ELLSWORTH, Bruce, A. , JURICA, Elizabeth, A. , SHI, Jun , EWING, William, R. , YE, Xiang-Yang , WU, Ximao , ZHU, Yeheng , SUN, Chongqing
IPC分类号： C07D401/14 , C07D401/12 , C07D487/04 , A61K31/402 , A61K31/4025 , A61P3/10
CPC分类号： C07D401/12 , A61K31/4025 , A61K31/454 , A61K31/4545 , A61K31/5025 , A61K31/506 , A61K45/06 , C07D207/08 , C07D207/12 , C07D401/10 , C07D401/14 , C07D487/04
摘要： The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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公开(公告)号：EP1653962A2
公开(公告)日：2006-05-10
申请号：EP04781313.4
申请日：2004-08-16
IPC分类号： A61K31/497 , A61K31/4965 , C07D241/00 , C07D241/02
CPC分类号： C07D241/24 , C07D401/06 , C07D401/14
摘要： The present application describes compounds according to Formula (I), wherein A, G1, G2 and R1 are described herein. Additionally, the present application describes pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents. Finally, the present application describes methods of treatment using the compounds according to Formula (I) both alone and in combination with one or more additional therapeutic agents.
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公开(公告)号：EP2925741B1
公开(公告)日：2016-10-26
申请号：EP13795972.2
申请日：2013-11-15
发明人： ELLSWORTH, Bruce, A. , JURICA, Elizabeth, A. , SHI, Jun , EWING, William, R. , YE, Xiang-Yang , WU, Ximao , ZHU, Yeheng , SUN, Chongqing
IPC分类号： C07D401/14 , C07D401/12 , C07D487/04 , A61K31/402 , A61K31/4025 , A61P3/10
CPC分类号： C07D401/12 , A61K31/4025 , A61K31/454 , A61K31/4545 , A61K31/5025 , A61K31/506 , A61K45/06 , C07D207/08 , C07D207/12 , C07D401/10 , C07D401/14 , C07D487/04
摘要： The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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公开(公告)号：EP2925749A1
公开(公告)日：2015-10-07
申请号：EP13795973.0
申请日：2013-11-15
发明人： ELLSWORTH, Bruce, A. , SHI, Jun , EWING, William, R. , JURICA, Elizabeth, A. , HERNANDEZ, Andres, S. , WU, Ximao , GU, Zhengxiang , HONG, Zhenqiu , O'CONNOR, Stephen, P.
IPC分类号： C07D405/14 , C07D401/12 , C07D405/12 , C07D417/14 , C07D451/06 , C07D403/12 , C07D401/10 , C07D487/08 , C07D211/16 , C07D211/18 , C07D413/14 , A61K31/4155 , A61P3/10 , C07D401/14
CPC分类号： C07D401/12 , A61K31/4155 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/497 , A61K31/506 , A61K31/55 , A61K45/06 , C07D401/10 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D451/06 , C07D471/08 , C07D487/08
摘要： The present invention provides compounds of Formula (I): (Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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